Patents by Inventor Thomas D. K. Brown

Thomas D. K. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA sequences encoding infectious bronchitis virus spike protein
    Patent number: 5032520
    Abstract: The problem of diagnosis and typing of infectious bronchitis virus in poultry has been solved and important progress made towards an IBV vaccine by this invention. DNA complementary to the region of genomic IBV RNA which codes for a spike protein polypeptide comprising the S1 polypeptide (containing antigenic determinants) or the S2 polypeptide (containing means for anchoring the spike protein to the viral membrane) has been made. It can be carried by a cloning vector, incorporated in a host and cloned. It can also be cloned in a poxvirus which is used to transfect mammmalian cells. Such cells express an artificial spike protein polypeptide.
    Type: Grant
    Filed: November 4, 1986
    Date of Patent: July 16, 1991
    Assignee: National Research Development Corporation
    Inventors: Matthew M. Binns, Michael E. G. Boursnell, Thomas D. K. Brown, Fiona M. Tomley