Patent number: 4578386
Abstract: Provided are compounds of the structure: ##STR1## wherein R.sub.1, R.sub.3, R.sub.5 and R.sub.6 are independently H, alkyl, aralkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl, alkynyl, hydroxy, hydroxyalkyl, alkoxy, mercapto, mercaptoalkyl, alkylthio, amino, alkylamino, aminoalkyl, formyl, carboxy and salts thereof, carbalkoxy, alkanoyl, cyano, nitro, halo, trifluoromethyl, alkylsulfonyl, aminosulfonyl, carbamoyl or cycloalkyl; andR.sub.7 is H, alkyl, aryl, aralkyl, oxo, or alkanoyl;wherein at least one of R.sub.1 R.sub.5 or R.sub.6 is an aryl, heteroaryl, or heteroaryl substituted with H, alkyl, halo, amino, trifluoromethyl or cyano.
Type:
Grant
Filed:
February 10, 1984
Date of Patent:
March 25, 1986
Assignee:
USV Pharmaceutical Corp.
Inventor:
Thomas D. Lee
Patent number: 4440929
Abstract: Provided are imidazoquinoxalines of the structures: ##STR1## wherein R.sub.1, R.sub.5, R.sub.6 and R.sub.7 are independently H, alkyl, aryl, alkenyl, alkynyl, hydroxy, hydroxyalkyl, alkoxy, mercapto, mercaptoalkyl, alkylthio, amino, alkylamino, aminoalkyl, carboxaldehyde, carboxylic acid and salts thereof, carbalkoxy, alkanoyl, cyano, nitro, halo, trifluoromethyl, alkylsulfonyl, sulfonamido, or R.sub.1, R.sub.5, R.sub.6 and R.sub.7 may be taken together with the adjacent group to form a methylenedioxy group.R.sub.4 is H, alkyl, alkenyl, alkynyl, aryl, aralkyl, hydroxy or alkanoyl.R.sub.3 is H, cyano, tetrazolo, carboxaldehyde, hydroxyalkyl, carboxylic acid and salts thereof or derivatives thereof such as esters or amides in which the substituent on the ester oxygen or amide nitrogen is alkyl, aryl, hydroxyalkyl, alkoxyalkyl or amino alkyl.R.sub.2 and R.sub.
Type:
Grant
Filed:
March 29, 1982
Date of Patent:
April 3, 1984
Assignee:
USV Pharmaceutical Corporation
Inventors:
Thomas D. Lee, Richard E. Brown