Patents by Inventor Thomas D. Madden

Thomas D. Madden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20230372537
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Application
    Filed: June 9, 2023
    Publication date: November 23, 2023
    Inventors: Michael J. Hope, Barbara Mui, Paulo Jia Ching Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du
  • Lipid nanoparticle formulations
    Patent number: 11712481
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: August 1, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Michael J. Hope, Barbara Mui, Paulo Jia Ching Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du
  • SCREENING METHOD FOR SELECTED AMINO-LIPID-CONTAINING COMPOSITIONS
    Publication number: 20220074925
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: April 2, 2021
    Publication date: March 10, 2022
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Marco A. Ciufolini, Thomas D. Madden, Michael J. Hope, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • SCREENING METHOD FOR SELECTED AMINO-LIPID-CONTAINING COMPOSITIONS
    Publication number: 20200225215
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: June 14, 2019
    Publication date: July 16, 2020
    Inventors: Marco A. Ciufolini, Thomas D. Madden, Michael J. Hope, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • Amino lipids and methods for the delivery of nucleic acids
    Patent number: 10653780
    Abstract: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: May 19, 2020
    Assignees: THE UNIVERSITY OF BRITISH COLUMBIA, ARBUTUS BIOPHARMA CORPORATION
    Inventors: Michael J. Hope, Sean C. Semple, Jianxin Chen, Thomas D. Madden, Pieter R. Cullis, Marco A. Ciufolini, Barbara Low Shoud Mui
  • LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20200121809
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Application
    Filed: October 26, 2017
    Publication date: April 23, 2020
    Inventors: Michael J. Hope, Barbara Mui, Jia Ching Paulo Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du
  • SCREENING METHOD FOR SELECTED AMINO-LIPID-CONTAINING COMPOSITIONS
    Publication number: 20180209963
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: September 1, 2017
    Publication date: July 26, 2018
    Applicant: Arbutus Biopharma Corporation
    Inventors: Marco A. Ciufolini, Thomas D. Madden, Michael J. Hope, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20160317676
    Abstract: A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.
    Type: Application
    Filed: May 11, 2016
    Publication date: November 3, 2016
    Applicants: Tekmira Pharmaceuticals Corporation, The University of British Columbia, Acuitas Therapeutics Inc.
    Inventors: Michael J. Hope, Thomas D. Madden, Pieter R. Cullis, Martin Maier, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Akin Akinc, Muthiah Manoharan, Ismail Hafez
  • SCREENING METHOD FOR SELECTED AMINO-LIPID-CONTAINING COMPOSITIONS
    Publication number: 20160274089
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: October 30, 2015
    Publication date: September 22, 2016
    Inventors: Marco A. Ciufolini, Thomas D. Madden, Michael J. Hope, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS
    Publication number: 20160095924
    Abstract: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Application
    Filed: August 28, 2015
    Publication date: April 7, 2016
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, TEKMIRA PHARMACEUTICALS CORPORATION
    Inventors: Michael J. Hope, Sean C. Semple, Jianxin Chen, Thomas D. Madden, Pieter R. Cullis, Marco A. Ciufolini, Barbara Low Shoud Mui
  • Amino lipids and methods for the delivery of nucleic acids
    Patent number: 9139554
    Abstract: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: September 22, 2015
    Assignees: Tekmira Pharmaceuticals Corporation, The University of British Columbia
    Inventors: Michael J. Hope, Sean C. Semple, Jianxin Chen, Thomas D. Madden, Pieter R. Cullis, Marco A. Ciufolini, Barbara Low Shoud Mui
  • SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS
    Publication number: 20140295449
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: October 21, 2013
    Publication date: October 2, 2014
    Applicant: Tekmira Pharmaceuticals, Inc.
    Inventors: Marco A. Ciufolini, Thomas D. Madden, Michael J. Home, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • Liposomal Camptothecins and Uses Thereof
    Publication number: 20130136787
    Abstract: This invention relates to improved liposomal camptothecin compositions and methods of manufacturing and using such compositions for treating neoplasia and for inhibiting angiogenesis.
    Type: Application
    Filed: June 28, 2012
    Publication date: May 30, 2013
    Applicant: Talon Therapeutics, Inc.
    Inventors: Thomas D. Madden, Sean C. Semple
  • METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20130017223
    Abstract: A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.
    Type: Application
    Filed: December 17, 2010
    Publication date: January 17, 2013
    Applicants: The University of British Columbia, ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Michael J Hope, Thomas D. Madden, Pieter R. Cullis, Martin Maier, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Akin Akinc, Muthiah Manoharan
  • SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS
    Publication number: 20120225434
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: May 1, 2012
    Publication date: September 6, 2012
    Applicants: ALNYLAM PHARMACEUTICALS, INC., The University of British Columbia, Tekmira Pharmaceuticals Corporation
    Inventors: Marco A. CIUFOLINI, Thomas D. Madden, Michael J. Hope, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS
    Publication number: 20110256175
    Abstract: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Application
    Filed: October 9, 2009
    Publication date: October 20, 2011
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, TEKMIRA PHARMACEUTICALS CORPORATION
    Inventors: Michael J. Hope, Sean C. Semple, Jianxin Chen, Thomas D. Madden, Pieter R. Cullis, Marco A. Ciufolini, Barbara Low Shoud Mui
  • COMPOSITIONS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS
    Publication number: 20110117125
    Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Application
    Filed: December 31, 2008
    Publication date: May 19, 2011
    Applicants: TEKMIRA PHARMACEUTICALS CORPORATION, THE UNIVERSITY OF BRITISH COLUMBIA, ALNYLAM PHARMACEUTICALS
    Inventors: Michael J. Hope, Sean C. Semple, Jianxin Chen, Thomas D. Madden, Barbara Mui, Pieter R. Cullis, Marco A. Ciufolini, Kim F. Wong, Muthiah Manoharan, Rajeev G. Kallanthottathil
  • SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS
    Publication number: 20110097720
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: December 31, 2008
    Publication date: April 28, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Marco A. Ciufolini, Thomas D. Madden, Michael J. Hope, Barbara Mui, De Fougerolles Antonin, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • LIPOSOMAL CAMPTOTHECINS AND USES THEREOF
    Publication number: 20110086826
    Abstract: This invention relates to improved liposomal camptothecin compositions and methods of manufacturing and using such compositions for treating neoplasia and for inhibiting angiogenesis.
    Type: Application
    Filed: December 9, 2010
    Publication date: April 14, 2011
    Applicant: TEKMIRA PHARMACEUTICALS CORPORATION
    Inventors: Thomas D. MADDEN, Sean F. SEMPLE
  • Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
    Patent number: 7811602
    Abstract: The present invention includes novel liposomes comprising dihydrosphingomyelin. The invention also includes compositions comprising these liposomes and a therapeutic agent, in addition to methods and kits for delivering a therapeutic agent or treating a disease, e.g., a cancer, using these compositions.
    Type: Grant
    Filed: May 16, 2005
    Date of Patent: October 12, 2010
    Assignee: Tekmira Pharmaceuticals Corporation
    Inventors: Pieter R Cullis, Thomas D Madden, Michael J Hope, Steven M Ansell, Barbara L S Mui, Sean C Semple, Norbert Maurer