Patents by Inventor Thomas D. Wang

Thomas D. Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220369933
    Abstract: An optical probe assembly as a confocal endomicroscope includes an optical focusing stage that focuses an output beam onto a sample and a mirror scanning stage that is movable for scanning the output beam in both a lateral two dimensional plane and an axial direction, using a side-view configuration. The side-view configuration allows for output beam illumination and fluorescent imaging of the sample with greater imaging resolution and improved access to hard to reach tissue within a subject.
    Type: Application
    Filed: July 24, 2018
    Publication date: November 24, 2022
    Inventors: Thomas D. Wang, Xiyu Duan, Haijun LI
  • Publication number: 20220331475
    Abstract: The present invention is directed to a hemostatic patch comprising a porous substrate and at least a pair of co-reactive polymer reagents comprising at least one nucleophilic polyalkylene oxide based component and at least one electrophilic polyalkylene oxide-based on the porous substrate in a molar ratio of about 0.2 to about 0.9:1 of primary nucleophilic groups in excess to available electrophilic groups. The present invention is also directed to processes for the manufacture and use of such hemostatic patches.
    Type: Application
    Filed: February 9, 2022
    Publication date: October 20, 2022
    Inventors: Nir Nativ, Thomas Weindl, Benjamin D. Fitz, Gerard Llanos, Guanghui Zhang, Yi-Lan Wang, Meng Deng
  • Patent number: 11466092
    Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: October 11, 2022
    Assignee: Bristol-Myers Squibb Company
    Inventors: Zhehong Cai, Indrani Chakraborty, Marie-Michelle Navarro Garcia, Thomas D. Kempe, Alan J. Korman, Alexander T. Kozhich, Hadia Lemar, Mark Maurer, Christina Maria Milburn, Michael Quigley, Xiang Shao, Mohan Srinivasan, Kent Thudium, Susan Chien-Szu Wong, Jochem Gokemeijer, Xi-Tao Wang, Han Chang, Patrick Guirnalda
  • Patent number: 11406720
    Abstract: The present disclosure relates to Fibroblast Growth Factor Receptor 2-specific peptide reagents, methods for detecting epithelial-derived cancer cells such as esophageal, colorectal, gastric, pancreatic or breast carcinoma cells using the peptide reagents, and methods for targeting such cells using the peptide reagents.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: August 9, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Thomas D. Wang, Juan Zhou
  • Publication number: 20220193271
    Abstract: The disclosure provides peptides, including labeled peptides, that selectively bind to the cMet protein. The disclosure also provides methods of detecting dysplastic cells and tissue, e.g., in the colon, providing early identification of precancerous and cancerous tissue.
    Type: Application
    Filed: February 21, 2020
    Publication date: June 23, 2022
    Inventors: Thomas D. Wang, Juan Zhou
  • Publication number: 20220160232
    Abstract: A compact single-axis confocal endomicroscope is provided, capable of complying within 2.8 mm diameter endoscope space requirements. The single-axis confocal endomicroscope uses a folded path design achieved between a fixed mirror and a lateral plane scanning mirror thereby producing a high numerical aperture that allows for diffraction-limited resolution with sub-surface depths. The scanning mirror is formed on a fixed-position, scanning MEMS assembly and has a central aperture that allows for illumination beam expansion in the folded path design. A series of spacers are used to retain beam focusing optical elements in fixed positioned relative to the scanning MEMS assembly for coupling with a single mode fiber.
    Type: Application
    Filed: March 18, 2020
    Publication date: May 26, 2022
    Inventors: Thomas D. Wang, Xiyu Duan, Gaoming Li, Haijun Li
  • Publication number: 20220155584
    Abstract: A scanning assembly for an optical instrument includes a reflector and a folded-beam spring assembly coupled to the reflector for deflecting the reflector for beam scanning. A lever suspension assembly is coupled to the folded-beam spring assembly and provides torsional movement of the reflector for beam scanning over a two-dimensional region, allowing for large total scan angles and large vertical displacements.
    Type: Application
    Filed: March 18, 2020
    Publication date: May 19, 2022
    Inventors: Haijun Li, Thomas D Wang
  • Publication number: 20220155579
    Abstract: A compact single-axis confocal endomicroscope is provided, capable of complying with 2.8 mm diameter endoscope space requirements. The single-axis confocal endomicroscope uses a folded path design achieved between a fixed mirror and a lateral plane scanning mirror thereby producing high numerical apertures that allow for diffraction-limited resolution in sub-surface scanning. The scanning mirror has a central aperture that allows for illumination beam expansion in the folded path design.
    Type: Application
    Filed: March 18, 2020
    Publication date: May 19, 2022
    Inventors: Thomas D. Wang, Haijun Li, Xiyu Duan, Gaoming Li
  • Patent number: 11248022
    Abstract: The present invention is directed to glypican-3-specific peptide reagents, methods for detecting hepatocellular carcinoma cells using the peptide reagents, and methods for targeting hepatocellular carcinoma cells using the peptide reagents.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: February 15, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Juan Zhou, Thomas D. Wang, Zhao Li, Bishnu P. Joshi
  • Patent number: 11235066
    Abstract: The present invention relates to micelle drug carriers and methods of using the micelles to deliver drugs to target cells. The micelles are useful, for example, for carrying and targeting drugs for the treatment of cancer to cancer cells. As one example, the disclosure provides pegylated octadecyl lithocholate micelles that are labeled with a peptide ligand for colorectal neo-plasia and that carry the small molecule mTOR inhibitor rapamycin to colorectal cancer cells.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: February 1, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Thomas D. Wang, Supang Khondee
  • Patent number: 11215805
    Abstract: A multi-photon optical probe includes a probe housing, a lateral scanning stage coupled to a lateral mirror assembly and a remote axial scanning stage coupled to an axial mirror assembly. The lateral scanning stage is adapted to scan output laser energy over a planar scan area of the sample by moving the lateral mirror assembly. The axial scanning stage is adapted to scan the output laser energy over a vertical depth range of the sample, which, combined with the planar scan area, forms a 3-dimensional volume. A controller operates in conjunction with a number of remote actuating legs coupled to the axial mirror assembly in order to provide level imaging plane which in turn provides for a clear scanned image.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: January 4, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Kenn Oldham, Jongsoo Choi, Xiyu Duan, Thomas D. Wang, Haijun Li
  • Publication number: 20210383512
    Abstract: A computer-implemented method includes receiving a raw data set representing an image of a sample, identifying a first set of extremum by analyzing the raw data set using a metric algorithm, identifying a second set of extremum by analyzing the first set of extremum, and generating, based on the second set of extremum, a reconstructed image of the sample. A phase correcting scanner includes one or more processors, one or more scanner adapted to sequentially sample an object to generate a vector of raw data representing the object in a Lissajous pattern, and memory storing instructions that, when executed by the one or more processors, cause the computing system to receive the vector of raw data, identify a first set of extremum by analyzing the raw data set using a metric algorithm, and identify a second set of extremum by analyzing the first set of extremum.
    Type: Application
    Filed: October 25, 2019
    Publication date: December 9, 2021
    Inventors: Kenn Oldham, Thomas D. Wang, Mayur Bhushan Birla, Xiyu Duan
  • Publication number: 20210253639
    Abstract: The disclosure is directed to heterodimeric peptide reagents that specifically bind epidermal growth factor receptor (EGFR) and epidermal receptor growth factor 2 (ErbB2), as well as methods for detecting, targeting, diagnosing and/or treating diseases of the esophagus, including esophageal carcinoma, esophageal adenocarcinoma (EAC), high grade dysplasia (HGD) of the esophagus, and Barrett's neoplasia in a patient using the heterodimeric peptide reagents.
    Type: Application
    Filed: May 16, 2019
    Publication date: August 19, 2021
    Inventors: Thomas D. Wang, Jing Chen
  • Patent number: 10858396
    Abstract: The present disclosure is directed to HER2-specific peptide reagents, methods for detecting pre-cancer (dysplasia), early cancer and/or cancer using the peptide reagents, and methods for targeting pre-cancerous (dysplastic) cells, and/or cancer cells using the peptide reagents.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: December 8, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Thomas D. Wang, Bishnu P. Joshi
  • Patent number: 10746738
    Abstract: The present invention is directed to claudin-1-specific peptide reagents, methods for detecting pre-cancer (dysplasia), early cancer and/or cancer using the peptide reagents, and methods for targeting pre-cancerous (dysplastic) cells, and/or cancer cells using the peptide reagents.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: August 18, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Thomas D. Wang, Emily Rabinsky, Bishnu P. Joshi
  • Publication number: 20200138979
    Abstract: The present disclosure relates to Fibroblast Growth Factor Receptor 2-specific peptide reagents, methods for detecting epithelial-derived cancer cells such as esophageal, colorectal, gastric, pancreatic or breast carcinoma cells using the peptide reagents, and methods for targeting such cells using the peptide reagents.
    Type: Application
    Filed: June 20, 2018
    Publication date: May 7, 2020
    Inventors: Thomas D. Wang, Juan Zhou
  • Patent number: 10642027
    Abstract: An optical probe scanning assembly for use in an optical probe includes a mirror assembly that focuses an illumination beam path and a collection beam path at a region of interest within the sample. The illumination beam and the collection beam overlap to form a confocal beam region. The mirror assembly is movable in an x-axis direction and in a y-axis direction to scan the confocal beam region within the sample. The scanning assembly further includes a scanning suspension system including a gimbal assembly connected to the mirror assembly to allow the mirror assembly to rotate about one or more axes. The mirror is thereby adapted to scan along at least two different orthogonal planes, one of which extends vertically into the sample.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: May 5, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Thomas D. Wang, Haijun Li, Xiyu Duan, Zhen Qiu, Kenn Oldham
  • Publication number: 20200102349
    Abstract: The present invention is directed to EGFR-specific and ErbB2-specific peptide reagents, methods for detecting pre-cancer, early cancer and/or cancer using the peptide reagents alone or in a multiplex format, and methods for targeting pre-cancer cells, early cancer cells and/or cancer cells using the peptide reagents.
    Type: Application
    Filed: December 9, 2019
    Publication date: April 2, 2020
    Inventors: Thomas D. Wang, Juan Zhou, Bishnu P. Joshi
  • Publication number: 20200096753
    Abstract: A multi-photon optical probe includes a probe housing, a lateral scanning stage coupled to a lateral mirror assembly and a remote axial scanning stage coupled to an axial mirror assembly. The lateral scanning stage is adapted to scan output laser energy over a planar scan area of the sample by moving the lateral mirror assembly. The axial scanning stage is adapted to scan the output laser energy over a vertical depth range of the sample, which, combined with the planar scan area, forms a 3-dimensional volume. A controller operates in conjunction with a number of remote actuating legs coupled to the axial mirror assembly in order to provide level imaging plane which in turn provides for a clear scanned image.
    Type: Application
    Filed: December 4, 2017
    Publication date: March 26, 2020
    Inventors: Kenn Oldham, Jongsoo Choi, Xiyu Duan, Thomas D. Wang, Haijun Li
  • Publication number: 20200010508
    Abstract: The present invention is directed to glypican-3-specific peptide reagents, methods for detecting hepatocellular carcinoma cells using the peptide reagents, and methods for targeting hepatocellular carcinoma cells using the peptide reagents.
    Type: Application
    Filed: March 7, 2018
    Publication date: January 9, 2020
    Inventors: Juan Zhou, Thomas D. Wang, Zhao Li, Bishnu P. Joshi