Patents by Inventor Thomas D. Willis

Thomas D. Willis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS
    Publication number: 20240068045
    Abstract: The disclosure provides methods for identifying genomic loci that are differentially methylated in neoplastic cancers, e.g., esophageal cancers. Identification of methylated genomic loci, and optionally in combination with the identification of somatic mutations in TP53, has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal neoplasias.
    Type: Application
    Filed: October 19, 2023
    Publication date: February 29, 2024
    Inventors: Sanford D. Markowitz, Joseph E. Willis, Helen Moinova, Thomas LaFramboise, Omar de la Cruz Cabrera, Amitabh Chak
  • Precircle probe nucleic acid amplification methods
    Patent number: 8383348
    Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: February 26, 2013
    Assignee: Board of Trustees of the Leland Stanford Junior University
    Inventors: Thomas D. Willis, Paul Hardenbol, Maneesh Jain, Viktor Stolc, Mostafa Ronaghi, Ronald W. Davis
  • DIRECT MULTIPLEX CHARACTERIZATION OF GENOMIC DNA
    Publication number: 20120065091
    Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
    Type: Application
    Filed: August 9, 2011
    Publication date: March 15, 2012
    Inventors: Thomas D. Willis, Paul Hardenbol, Maneesh Jain, Viktor Stolc, Mostafa Ronaghi, Ronald W. Davis
  • Precircle probe nucleic acid amplification methods
    Patent number: 7993880
    Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: August 9, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thomas D. Willis, Paul Hardenbol, Maneesh Jain, Viktor Stolc, Mostafa Ronaghi, Ronald W. Davis
  • DIRECT MULTIPLEX CHARACTERIZATION OF GENOMIC DNA
    Publication number: 20100330619
    Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
    Type: Application
    Filed: February 19, 2010
    Publication date: December 30, 2010
    Inventors: Thomas D. Willis, Paul Hardenbol, Maneesh Jain, Viktor Stolc, Mostafa Ronaghi, Ronald W. Davis
  • Method for detecting and amplifying target DNA
    Patent number: 7700323
    Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: April 20, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thomas D Willis, Paul Hardenbol, Maneesh Jain, Viktor Stolc, Mostafa Ronaghi, Ronald W Davis
  • Direct multiplex characterization of genomic DNA
    Patent number: 6858412
    Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: February 22, 2005
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thomas D. Willis, Paul Hardenbol, Maneesh Jain, Viktor Stolc, Mostafa Ronaghi, Ronald W. Davis
  • DIRECT MULTIPLEX CHARACTERIZATION OF GENOMIC DNA
    Publication number: 20040101835
    Abstract: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
    Type: Application
    Filed: October 24, 2001
    Publication date: May 27, 2004
    Inventors: Thomas D. Willis, Paul Hardenbol, Maneesh Jain, Viktor Stolc, Mostafa Ronaghi, Ronald W. Davis