Patents by Inventor Thomas D. Wu

Thomas D. Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIAGNOSTIC METHODS AND COMPOSITIONS FOR CANCER IMMUNOTHERAPY
    Publication number: 20210301023
    Abstract: The present invention provides diagnostic methods, therapeutic methods, and compositions for the treatment of cancer. The compositions and methods described herein can be used, for example, to determine the propensity of a patient to benefit from treatment with a PD-L1 axis binding antagonist and to treat such patients accordingly. Using the compositions and methods of the disclosure, a patient, such as a human cancer patient, may be determined to be likely to benefit from treatment with a PD-L1 axis binding antagonist if the patient exhibits an elevated pre-treatment expression level of one or more of CST7, NKG7, GZMH, MT-ND4, HLA-H, CCL5, CD8A, CMC1, CD8B, HCST, MT-CYB, MT-ND4L, KLRG1, MT-CO2, MT-ATP6, PLEK, CTSW, HLA-C, LYAR, LITAF, GZMB, KLRD1, FGFBP2, KLRC4-KLRK1, KLRK1, B2M, GZMA, ID2, CX3CR1, PRSS23, GNLY, PRF1, and PATL2.
    Type: Application
    Filed: June 4, 2021
    Publication date: September 30, 2021
    Inventors: Thomas D. WU, Jane Louise GROGAN
  • METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER
    Publication number: 20150376289
    Abstract: Methods and compositions are provided for the diagnosis and treatment of lung cancers in particular NSCLC associated with amplification or overexpression of the PRO gene, i.e. any of PDGFRA, KIT or KDR.
    Type: Application
    Filed: September 2, 2015
    Publication date: December 31, 2015
    Inventors: John Chant, Anthony S. Guerrero, Peter Haverty, Cynthia Honchell, Kenneth Jung, Thomas D. Wu
  • Compositions and methods for the treatment of immune related diseases
    Publication number: 20140371086
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: May 29, 2014
    Publication date: December 18, 2014
    Inventors: Alexander Abbas, Hilary Clark, Wenjun Ouyang, P. Mickey Williams, William I. Wood, Thomas D. Wu
  • Methods for the treatment of tumors expressing TAT123 or naturally occurring variants thereof
    Patent number: 8728480
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: May 20, 2014
    Assignee: Genetech, Inc.
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20140018250
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: July 13, 2012
    Publication date: January 16, 2014
    Inventors: Alexander ABBAS, Sarah C. Bodary, Hilary Clark, Jill R. Schoenfeld, P. Mickey Williams, William I. Wood, Thomas D. Wu
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20130165332
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: July 13, 2012
    Publication date: June 27, 2013
    Inventors: Alexander ABBAS, Hilary Clark, Wenjun Ouyang, P. Mickey Williams, William I. Wood, Thomas D. Wu
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 8398982
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. TAT113 polypeptides comprising the amino acid sequence of SEQ ID NO: 2 are disclosed. Antibodies that bind TAT113 polypeptides, including monoclonal, chimeric, humanized, single chain, and other antibodies, and fragments thereof, are disclosed. Methods of identifying antibodies that bind epitopes bound by such antibodies, including the antibodies produced by hybridoma cell lines disclosed in the application, are provided, wherein the ability of one antibody to block the binding of another antibody to a TAT113 polypeptide indicates that one antibody binds to an epitope bound by the other antibody.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: March 19, 2013
    Assignee: Genentech, Inc.
    Inventors: Patrick Dowd, Gretchen Frantz, Paul Polakis, Victoria Smith, Susan D. Spencer, Thomas D. Wu, Zemin Zhang
  • Methods for the treatment of tumors expressing TAT123 or naturally occurring variants thereof
    Publication number: 20130064761
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: November 10, 2011
    Publication date: March 14, 2013
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • Compositions and methods for the treatment of immune related diseases
    Publication number: 20130059752
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: August 28, 2012
    Publication date: March 7, 2013
    Inventors: Sarah C. Bodary-Winter, Hilary Clark, Brisdell Hunte, Janet K. Jackman, Jill R. Schoenfeld, P. Mickey Williams, William I. Wood, Thomas D. Wu
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20130011402
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: April 13, 2009
    Publication date: January 10, 2013
    Inventors: Patrick Dowd, Gretchen Frantz, Paul Polakis, Victoria Smith, Susan D. Spencer, Thomas D. Wu, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 8278042
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: October 2, 2012
    Assignee: Genentech, Inc.
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20120083420
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: September 27, 2010
    Publication date: April 5, 2012
    Inventors: HILARY CLARK, Jill R. Schoenfeld, Menno VanLookeren, P. Mickey Williams, William I. Wood, Thomas D. Wu
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20120035073
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: September 23, 2011
    Publication date: February 9, 2012
    Inventors: Sarah C. Bodary-Winter, Hilary Clark, Brisdell Hunte, Janet K. Jackman, Jill R. Schoenfeld, P. Mickey Williams, William I. Wood, Thomas D. Wu
  • TAT294 polypeptides
    Patent number: 8097700
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: January 17, 2012
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Dan L. Eaton, Audrey Goddard, Austin L. Gurney, William I. Wood, Thomas D. Wu
  • Novel composition and methods for the treatment of psoriasis
    Publication number: 20120003246
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of psoriasis.
    Type: Application
    Filed: June 21, 2011
    Publication date: January 5, 2012
    Inventors: Sarah C. Bodary-Winter, Hilary Clark, Janet K. Jackman, Jill R. Schoenfeld, William I. Wood, Thomas D. Wu
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 8084200
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: December 27, 2011
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Gretchen Frantz, Audrey Goddard, Lino Gonzalez, Austin L. Gurney, Paul Polakis, Andrew Polson, William I. Wood, Thomas D. Wu, Zemin Zhang
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20110274690
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: April 13, 2009
    Publication date: November 10, 2011
    Inventors: Patrick Dowd, Gretchen Frantz, Paul Polakis, Victoria Smith, Susan D. Spencer, Thomas D. Wu, Zemin Zhang
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20110245090
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: March 11, 2011
    Publication date: October 6, 2011
    Inventors: Alexander Abbas, Hilary Clark, Wenjun Ouyang, P. Mickey Williams, William I. Wood, Thomas D. Wu
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20110243930
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: February 10, 2011
    Publication date: October 6, 2011
    Inventors: SARAH C. BODARY-WINTER, Hilary Clark, Brisdell Hunte, Janet K. Jackman, Jill R. Schoenfeld, P. Mickey Williams, William I. Wood, Thomas D. Wu
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20110245096
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: February 23, 2011
    Publication date: October 6, 2011
    Inventors: Sudeepta Aggarwal, Hilary Clark, Austin L. Gurney, Jill R. Schoenfeld, P. Mickey Williams, William I. Wood, Thomas D. Wu