Abstract: An external fixation frame for correcting a bone deformity includes a first fixation ring and a second fixation ring. A posterior adjustable length strut couples a posterior portion of the first fixation ring to a posterior portion of the second fixation ring and has universal joint. Medial and lateral adjustable length struts couples medial and lateral portions of the first fixation ring to medial and lateral portions of the second fixation ring respectively, each of the medial and lateral adjustable length struts including a constrained hinge joint. The fixation frame also includes a half ring hingedly coupled to the second fixation ring, and an anterior adjustable length strut coupling an anterior portion of the first fixation ring to the half ring.

Abstract: An external fixator system comprising at least two fixation plates which are arranged at a distance to each another, at least one adjustable length strut having a first end region and a second end region which are in connection with the fixation plates and at least one actuation unit to adjust the length of the strut in order to adjust the distance and/or orientation between the fixation plates. The actuation unit is in a fixed connection with at least one of the fixation plates as well as with at least one of the end regions of the respective strut in order to connect the strut with the fixation plate. The actuation unit comprises a feedback unit which provides the user with a feedback concerning the degree of the actuation.

Abstract: An external fixator system comprising at least two fixation plates which are arranged at a distance to each another, at least one adjustable length strut having a first end region and a second end region which are in connection with the fixation plates and at least one actuation unit to adjust the length of the strut in order to adjust the distance and/or orientation between the fixation plates. The actuation unit is in a fixed connection with at least one of the fixation plates as well as with at least one of the end regions of the respective strut in order to connect the strut with the fixation plate. The actuation unit comprises a feedback unit which provides the user with a feedback concerning the degree of the actuation.

Abstract: A method for estimating a time at which a pressure window relevant observation occurred relating to an event that occurred in an open borehole penetrating an earth formation includes: receiving with a processor a pressure window relevant observation that provides input to adjusting a pressure window for drilling fluid for drilling the borehole; and estimating with the processor a time window in which a physical parameter, a chemical parameter, or a process that caused the pressure window relevant observation to occur, the time window having a start time and an end time.

Abstract: Disclosed is a method for estimating a geometry of a borehole penetrating the earth. The method includes: performing a plurality of borehole caliper measurements with N transducers at a plurality of times, wherein for each time a measurement set comprises measurements made by the N transducers at that time; dividing a cross-section of the borehole into S sectors; obtaining an estimate of the borehole geometry by connecting representative radius points in adjacent sectors; displacing each measurement set according to a displacement vector related to an offset of each measurement set from the estimated geometry if the displacement vector exceeds a selection criterion; iterating the obtaining an estimate of the borehole geometry and the displacing each measurement set based on a latest displacement vector; and providing a latest obtained estimate as the geometry of the borehole when all of the displacement vectors no longer exceed the selection criterion for the displacing.

Abstract: Disclosed herein are methods and compositions for the eradication of bacterial infections. In particular, methods and compositions are disclosed for the eradication of persister and slow growing bacterial cell populations. In particular embodiments, the methods and compositions disclosed herein are useful for eradication of biofilms.

Abstract: Disclosed herein is a method of locating and quantifying friction between a drillstring and a wellbore. The method includes, positioning a plurality of sensors within a wellbore, communicatively coupling the plurality of sensors, monitoring signals from the plurality of sensors, logging the sensed signals versus time versus depth of each of the plurality of sensors, locating at least one friction zone along the drillstring within the wellbore based on the logging and quantifying friction in the at least one friction zone based on the logging.

Abstract: Disclosed is a method for estimating a geometry of a borehole penetrating the earth. The method includes: performing a plurality of borehole caliper measurements with N transducers at a plurality of times, wherein for each time a measurement set comprises measurements made by the N transducers at that time; dividing a cross-section of the borehole into S sectors; obtaining an estimate of the borehole geometry by connecting representative radius points in adjacent sectors; displacing each measurement set according to a displacement vector related to an offset of each measurement set from the estimated geometry if the displacement vector exceeds a selection criterion; iterating the obtaining an estimate of the borehole geometry and the displacing each measurement set based on a latest displacement vector; and providing a latest obtained estimate as the geometry of the borehole when all of the displacement vectors no longer exceed the selection criterion for the displacing.

Abstract: Disclosed is a method of treating a subject with cancer, the method comprising the step of co-administering to the subject over three to five weeks, a taxane in an amount of between about 243 ?mol/m2 to 315 ?mol/m2; and a bis(thiohydrazide amide) compound in an amount between about 1473 ?mol/m2 and about 1722 ?mol/m2.

Abstract: A method of treating a subject with cancer includes the step of co-administering to the subject over three to five weeks, a taxane in an amount of between about 243 ?mol/m2 to 315 ?mol/m2 (e.g., equivalent to paclitaxel in about 210-270 mg/m2); and a bis(thiohydrazide amide) in an amount between about 1473 ?mol/m2 and about 1722 ?mol/m2 (e.g., Compound (1) in about 590-690 mg/m2). The bis(thiohydrazide amide) is represented by Structural Formula (I), Y is a covalent bond or an optionally substituted straight chained hydrocarbyl group, or, Y, taken together with both >C=Z groups to which it is bonded, is an optionally substituted aromatic group. R1-R4 are independently —H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring.

Abstract: A system for discharging inert gas for extinguishing or suppressing a fire is disclosed. A fluid discharge control arrangement is positioned in a fluid flow path between a pressurised gas supply 10A,10B,10C and the target fire suppression zone 20. The fluid discharge control arrangement reduces the pressure in the fluid flow path downstream thereof. This may allow the downstream pipework to be selected to withstand a lower pressure than in a conventional system in which the fluid discharge control device was not provided, thereby reducing costs. The fluid discharge control device may comprise a first valve 30 and first restrictor 26 in the first flow path 22 and a second valve 32 and a second restrictor 28 provided in the second flow path 24. Fluid from the containers 10A,10B,10C flows initially through flow path 24 and restrictor 26. Subsequently flow path 22 may be closed by optional valve 30, and flow path 24 is opened by valve 32. Fluid flow then passes through restrictor 28.

Abstract: Disclosed herein is a method of locating and quantifying friction between a drillstring and a wellbore. The method includes, positioning a plurality of sensors within a wellbore, communicatively coupling the plurality of sensors, monitoring signals from the plurality of sensors, logging the sensed signals versus time versus depth of each of the plurality of sensors, locating at least one friction zone along the drillstring within the wellbore based on the logging and quantifying friction in the at least one friction zone based on the logging.

Abstract: A method of treating a subject with cancer includes the step of co-administering to the subject over three to five weeks, a taxane in an amount of between about 243 ?mol/m2 to 315 ?mol/m2 (e.g., equivalent to paclitaxel in about 210-270 mg/m2); and a bis(thiohydrazide amide) in an amount between about 1473 ?mol/m2 and about 1722 ?mol/m2 (e.g., Compound (1) in about 590-690 mg/m2). The bis(thiohydrazide amide) is represented by Structural Formula (I), Y is a covalent bond or an optionally substituted straight chained hydrocarbyl group, or, Y, taken together with both >C=Z groups to which it is bonded, is an optionally substituted aromatic group. R1-R4 are independently —H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring.

Abstract: A connector for detachably interconnecting a number of strips (3), each of which has at least one perforation (4) and which in at least one mutual connection position is flush with the perforations (4) in the other strips (3). The connector (1,10,16,21,26,31,36) comprises at least one pin (6,20,25,30,37) and at least one hook (5,8,9;11,14,15;17,18,19;22,23,24;27,28,29) attached to the at least one pin, the at least one pin is engaging the flush perforations in the strips in the connected state of these at the same time as the at least one hook is encompassing the strips, and the strips are detachably interconnected only by means of said at least one pin and said at least one hook. The connector has a simple construction and is able to easily and quickly connect two or more strips immediately in positions where co-operating perforations are flush with each other without the need to first pass the strips through the connector.

Abstract: A system for drilling a well comprises a tubular member having a bottomhole assembly at a bottom end thereof disposed in a wellbore. A first sensor is disposed in the bottomhole assembly at a predetermined axial location for detecting bending in a first axis and generating a first bending signal in response thereto, where the first axis is substantially orthogonal to a longitudinal axis of the bottomhole assembly. A second sensor is disposed in the bottomhole assembly at the predetermined axial location for detecting bending in a second axis and generating a second bending signal in response thereto, where the second axis is substantially orthogonal to the longitudinal axis. A processor receives the first bending signal and the second bending signal and relates the first bending signal and the second bending signal to a borehole curvature according to programmed instructions.

Abstract: A connector for detachably interconnecting a number of strips (3), each of which has at least one perforation (4) and which in at least one mutual connection position is flush with the perforations (4) in the other strips (3). The connector (1,10,16,21,26,31,36) comprises at least one pin (6,20,25,30,37) and at least one hook (5,8,9;11,14,15;17,18,19;22,23,24;27,28,29) attached to the at least one pin, the at least one pin is engaging the flush perforations in the strips in the connected state of these at the same time as the at least one hook is encompassing the strips, and the strips are detachably interconnected only by means of said at least one pin and said at least one hook. The connector has a simple construction and is able to easily and quickly connect two or more strips immediately in positions where co-operating perforations are flush with each other without the need to first pass the strips through the connector.

Abstract: A system for drilling a well comprises a tubular member having a bottomhole assembly at a bottom end thereof disposed in a wellbore. A first sensor is disposed in the bottomhole assembly at a predetermined axial location for detecting bending in a first axis and generating a first bending signal in response thereto, where the first axis is substantially orthogonal to a longitudinal axis of the bottomhole assembly. A second sensor is disposed in the bottomhole assembly at the predetermined axial location for detecting bending in a second axis and generating a second bending signal in response thereto, where the second axis is substantially orthogonal to the longitudinal axis. A processor receives the first bending signal and the second bending signal and relates the first bending signal and the second bending signal to a borehole curvature according to programmed instructions.

Abstract: A device for keeping items in a vehicle in position wherein the device includes a fabric defining at least one recess for receiving said items. The device is movable between a first position, wherein the recess is accessible for receiving said items, and a second position wherein the recess is hidden and inaccessible for receiving said items. A spring forces the device from the first position to the second position.

Abstract: The present invention relates to an apparatus for a cleaning carriage (2, 102) for rinsing, cleaning and wringing out a mop. More precisely, the apparatus comprises a mop container (6, 106, 202) having connecting sidewalls, a mop-wringing device (14, 50, 116), and also a collecting bowl (24, 52, 124, 200) arranged at the mop container to which cleaning agent is added through a separate vessel for rinsing and cleaning of the mop in the collecting bowl, the collecting bowl (24, 52, 124, 200) comprises liquid-sealed interfaces such that cleaning agent can be filled up in the collecting bowl for rinsing and cleaning of the mop, and also that devices (32, 66, 166, 206; 36, 56, 122, 172, 210) are arranged in connection to the collecting bowl for emptying of the same. The present invention also relates to a method and a use.