Abstract: A system and method for assigning a workload to one of a plurality of candidate host machines of a computing environment. The method may include receiving a request to schedule a workload, selecting a virtual machine type for executing the workload, for each candidate host machine of the plurality of candidate host machines, determining an expected waste score indicating a likelihood of resources at the candidate host machine remaining unused if the virtual machine type is assigned to the candidate host machine, selecting the candidate host machine for which the expected waste score is the lowest, and assigning the workload to the selected candidate host machine.

Abstract: An augmented-reality (AR) eyewear display utilizes an optical waveguide having multi-layered optical gratings in a repeating arrangement. The optical gratings include varying depths, slope angles, lengths, and/or widths in order to tune the gratings to provide an improved AR eyewear display. By using the different configurations of two-dimensional or three-dimensional gratings disclosed herein in a waveguide of an AR eyewear display, optical characteristics of the waveguide are optimized to provide, e.g., high resolution and/or contrast, high display uniformity, high input coupling efficiency, and/or high output coupling efficiency. Accordingly, in some embodiments, aspects of the present disclosure enable lower-power AR eyewear displays to produce the same quality of display of a higher-power conventional AR eyewear display waveguide.

Abstract: The invention provides a CLIPTAC comprising: (a) a first portion comprising a ligand for an intracellular target protein; (b) a second portion comprising a ligand for an E3 ubiquitin ligase; and (c) a linker portion covalently coupling the first and second portions; wherein the linker comprises a covalent bond produced by a bioorthogonal click reaction between a compatible pair of reactive moieties. CLIPTAC precursor compositions and CLIPTAC precursors are also provided, together with pharmaceutical compositions comprising the CLIPTAC, CLIPTAC precursor compositions and CLIPTAC precursors, and methods of treatment using the same.

Abstract: The present disclosure generally relates to user interfaces for electronic audio devices. In some examples, the operating mode of the device changes to various states of sound transparency.

Abstract: A spectrometer apparatus is disclosed that includes at least one light source for irradiating a sample with light, an optical detection device for detecting light scattered by the sample, at least one optical filter device, which is arranged in front of and/or behind the sample, a contact sensor device for determining a contact between the sample and the spectrometer apparatus and for outputting a corresponding output signal, a control device for controlling the light source and the detection device in response to the output signal. The control device is designed such that the control device modifies at least one operating parameter of the light source and the detection device, when the output signal indicates the contact between the sample and the spectrometer apparatus. A method for operating a spectrometer apparatus is disclosed as well.

Abstract: A system includes a PTO device that selectively couples to a driveline of a vehicle, a motor/generator electrically coupled to an electrical power storage system, and a shared load selectively powered by one of the driveline or the motor/generator. The PTO device further includes a coupling actuator that couples the shared load to the motor/generator at a first selected ratio in a first position, and couples the shared load to the driveline at a second selected ratio in a second position.

Abstract: Disclosed herein is an overbased alkaline earth metal hydrocarbyl-substituted salicylate detergent comprising both carbonate and borate moieties and exhibiting the following characteristics: a basicity index of at least 3.8; a ratio of soap content to mass % boron is greater than 55 mmol/kg; a soap content of at least 330 mmol/kg; a TBN, measured according to ASTM D2896, of at least 220 mg KOH/g; and a mass ratio of borate to carbonate from 0.75 to 6.0, wherein the alkaline earth metal comprises calcium and/or magnesium, and the hydrocarbyl substitution comprises 9 to 30 carbon atoms. Methods of making the boron-containing salicylate detergent, specifically to be package-stable, are also disclosed, as well as package-stable lubricant additive package concentrates and lubricating oil compositions containing same.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Methods, systems, and apparatus, for a stray-light testing station. In one aspect, the stray-light testing station includes an illumination assembly including a spatially extended light source and one or more optical elements arranged to direct a beam of light from the spatially extended light source along an optical path to an optical receiver assembly including a lens receptacle configured to receive a lens module and position the lens module in the optical path downstream from the parabolic mirror so that the lens module focuses the beam of light from the spatially extended light source to an image plane, and a moveable frame supporting the optical receiver assembly including one or more adjustable alignment stages to position the optical receiver assembly relative to the illumination assembly such that the optical path of the illumination assembly is within a field of view of the optical receiver assembly.

Abstract: A method of printing a multi-material part in a layer-wise manner with an extrusion-based 3D printer includes providing a sliced digital model of a multi-material part and determining a number of materials in each of the slices of the digital mode. The method includes utilizing a digital model of a purge tower having N subdivisions having a closed geometry, wherein N is the number of print heads needed to print the part that is greater than or equal to three, each adjacent subdivision contact one another along an interface and assigning each print head to one subdivision and to tool paths forming the one subdivision in each layer. The method includes reassigning the assigned subdivision within the purge tower of an inactive print head in a layer to a print head that is active in the layer of the multi-material part.

Abstract: Described herein is a mobile device with an optical detector including: at least one illumination source adapted to generate at least one illumination pattern for illuminating an object, where the illumination pattern includes a regular and/or constant and/or periodic pattern; at least one sensor element having a matrix of optical sensors, the optical sensors each having a light-sensitive area, where each optical sensor is configured to generate at least one sensor signal in response to an illumination of the light-sensitive area by at least one light beam propagating from the object to the detector; and at least one evaluation device adapted to determine at least one region of interest.

Abstract: A radioisotope generator including a laser, a volume of target isotope, and nanoparticles in a solid, liquid, or gas state is provided. In at least one aspect, the radioisotope generator accelerates the decay rate of an isotope, with the laser being used to accelerate the decay of the isotope for the production of desired product isotopes.

Abstract: A dialysis machine includes a user interface for providing visual information and/or spoken information to a user. For example, in some implementations, the user interface may be configured to provide visual information related to an action, such as showing the action being partially or fully completed, and a speaker can provide spoken instructions to assist the user in machine set-up, calibration and/or operation. Such instructions can be particularly useful in a home dialysis setting. In some implementations, the speaker can provide spoken alarms that are related to alarm conditions. The spoken alarms may include patient and/or dialysis machine identifying information. The verbosity of the spoken instructions and/or the spoken alarms may be adjustable, and both may be accompanied by visual information displayed by the dialysis machine (e.g. visual alarms, images and/or video).

Abstract: The present invention relates to a bioactive sweet whey protein concentrate or composition for increasing e.g. cognitive functions particularly in young mammals such as pre-term or term infants, toddlers, children or young adults. The present invention further disclose a new concept for large-scale industrial production method of bioactive whey protein concentrates or compositions by use of mild heat treatment and pressure driven membrane separation.

Abstract: Provided herein are fluid-absorbent articles, fluid absorbent cores, and fluid-absorbent mixtures with improved properties, especially rewet performance and liquid acquisition. The fluid-absorbent article includes (A) an upper liquid-pervious sheet, (B) a lower liquid-impervious sheet, (C) a fluid-absorbent core including from 60 to 20% by weight fibrous material and from 40 to 80% by weight of at least a first type of water-absorbent polymer particles, (G) and at least a second type of water-absorbent polymer particles (H) based on the sum of water-absorbent polymer particles and fibrous material, (D) an optional acquisition-distribution layer (D) between (A) and (C), (F) other optional components, wherein the first type of water absorbent polymer particles (G) of the fluid-absorbent core (C) have a SFC of at least 20×10?7 cm3·s/g, and wherein the at least second type of water-absorbent polymer particles (H) of the fluid-absorbent core have a sphericity of at least 0.80.

Abstract: The various embodiments disclosed herein provide methods, systems, and devices for capturing broadcast streams, analyzing the broadcast streams to obtain information about the media content transmitted in the broadcast streams, obtaining additional information about the media content if available, and assigning a unique event identifier specific to the instance of broadcast of the broadcast stream and/or media segment transmitted in the broadcast stream. In other embodiments, the unique event identifier is broadcasted to broadcast receiving devices. With the unique event identifier, broadcast receiving devices can access the obtained information associated with the media content.

Abstract: The user can respond to a media segment wherein the media segment may be associated with a schedulable event. Software on the device can then schedule the event into an electronic calendar system, and/or may use data associated with the media segment. At the appropriate time, the electronic calendar system may notify the user of the scheduled broadcast and/or event.

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: A method of pneumatically conveying superabsorbent particles, wherein the superabsorbent particles have been admixed with an aqueous wax dispersion prior to the pneumatic conveying, the wax has a glass transition temperature of at least 65° C. and, based on the untreated superabsorbent particles, from 0.020% to 0.20% by weight of wax has been used.

Abstract: An eye measurement system includes an optical system. The eye measurement system is disposed in a housing which includes an aperture for providing light to and from the optical system and a subject's eye while the subject is separated and spaced apart from the housing, and the eye is not maintained in a fixed positional relationship with respect to the housing. An optical system movement arrangement moves the optical system. An automatic eye tracking arrangement ascertains a current positional relationship of the eye with respect to the optical system without human assistance, and in response thereto controls the optical system movement arrangement to move the optical system into a predetermined positional relationship with respect to the eye, for measurement of the eye, without human assistance. The eye measurement system can make objective, and/or subjective, refraction measurements of the eye.