Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A tubular steel golf shaft comprising a grip section, a tapered mid-section and a tip section. A loading zone is selectively formed along a portion of the shaft, preferably in the tapered mid-section, comprising a continuous series of closely spaced micro-steps, or reductions in diameter, each of which are less than 0.5 inches in length. Each micro-step section, in the direction from the grip section toward the tip section comprises a first peak which descends to valley and then ascends to a second peak. The diameter of the first peak is greater than the diameter of the second peak. A method of manufacturing the golf shaft is also disclosed.

Abstract: A tubular steel golf shaft comprising a grip section, a tapered mid-section and a tip section. A loading zone is selectively formed along a portion of the shaft, preferably in the tapered mid-section, comprising a continuous series of closely spaced micro-steps, or reductions in diameter, each of which are less than 0.5 inches in length. Each micro-step section, in the direction from the grip section toward the tip section comprises a first peak which descends to valley and then ascends to a second peak. The diameter of the first peak is greater than the diameter of the second peak. A method of manufacturing the golf shaft is also disclosed.