Abstract: Described are various embodiments of a patient lift and positioning system, and adjustable components thereof. In one embodiment, a patient positioning interface is suspended from a patient support mechanism and used in positioning a thus supported patient in two or more positions. The interface comprises a legrest portion for supporting a lower body portion of the patient and a backrest portion pivotally coupled to the legrest portion for supporting an upper body portion of the patient. The interface further comprises a powered drive mechanism independently acting on each of the legrest portion and the backrest portion to independently adjust relative to one another a legrest and backrest angle of the legrest portion and backrest portion, respectively.