Patents by Inventor Thomas Daniel Willis

Thomas Daniel Willis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multiplex PCR
    Patent number: 7510829
    Abstract: Compositions and methods for nucleic acid amplification are provided that minimize the formation and amplification of spurious products, particularly in multiplex amplification reactions. Linear amplification molecules are provided. A first embodiment comprises a first common primer sequence, a first template homology region, a cleavable site, a second common primer sequence and a second template homology region. Methods employing the linear amplification molecules for nucleic acid amplification are also provided. A first embodiment comprises a template-specific hybridization, a linear amplification, a template-specific intramolecular hybridization, a strand cleavage, a second linear amplification and an exponential amplification using common primers.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: March 31, 2009
    Assignee: Affymetrix, Inc.
    Inventors: Malek Faham, Eugeni Anatolyevich Namsaraev, Thomas Daniel Willis
  • Multiplex PCR
    Publication number: 20030104459
    Abstract: Compositions and methods for nucleic acid amplification are provided that minimize the formation and amplification of spurious products, particularly in multiplex amplification reactions. Linear amplification molecules are provided. A first embodiment comprises a first common primer sequence, a first template homology region, a cleavable site, a second common primer sequence and a second template homology region. Methods employing the linear amplification molecules for nucleic acid amplification are also provided. A first embodiment comprises a template-specific hybridization, a linear amplification, a template-specific intramolecular hybridization, a strand cleavage, a second linear amplification and an exponential amplification using common primers.
    Type: Application
    Filed: November 19, 2002
    Publication date: June 5, 2003
    Inventors: Malek Faham, Eugeni Anatolyevich Namsaraev, Thomas Daniel Willis