Abstract: The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof: wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-?-lactamase enzymes, in combination with antibiotics.

Abstract: A system including a LiDAR system of an autonomous vehicle. The LiDAR system includes at least one light emitter and at least one light detector to generate analog output signals based on reflected pulses of light. A comparator receives the analog output signals from the light detector and generates digital output signals based on the analog output signals and a threshold. A controller receives a first digital output signal of the digital output signals from the comparator based on the threshold, adjusts the threshold, receives at least one further digital output signal of the digital output signals from the comparator based on the threshold as adjusted, and/or determines at least one aggregation based on the first digital output signal and the further digital output signal(s).

Abstract: Neutron shielding. The neutron shielding comprises a plurality of absorption layers (201, 203), and at least one moderating layer (202). The plurality of absorption layers each comprise tungsten boride or tungsten carbide. The at least one moderating layer comprises a metal hydride. Each moderating layer is between at least two absorption layers.

Abstract: A method is described for proving erasure of a memory. In the method a prover device receives a seed value from a verifier device. The prover device generates a series of data blocks starting with the seed value and a function. The series of data blocks is generated using the function and the seed to generate a first data block of the series of data blocks. Each subsequent data block is generated using the function and a preceding data block until a last data block of the series of data blocks is generated and written to the memory portion. The prover device writes the series of data blocks to the memory to overwrite all memory contents of a memory portion of the prover device. After the data blocks are written to the memory by the prover device, the prover device sends notification of memory erasure to the verifier device.

Abstract: The invention relates to an indane compound according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, n and p are as defined herein. The compounds are useful for treating antibacterial infection either as stand-alone antibiotics, or in combination with further antibiotics.

Abstract: The invention relates to an indane compound according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, n and p are as defined herein. The compounds are useful for treating antibacterial infection either as stand-alone antibiotics, or in combination with further antibiotics.

Abstract: A method is described for proving erasure of a memory. In the method a prover device receives a seed value from a verifier device. The prover device generates a series of data blocks starting with the seed value and a function. The series of data blocks is generated using the function and the seed to generate a first data block of the series of data blocks. Each subsequent data block is generated using the function and a preceding data block until a last data block of the series of data blocks is generated and written to the memory portion. The prover device writes the series of data blocks to the memory to overwrite all memory contents of a memory portion of the prover device. After the data blocks are written to the memory by the prover device, the prover device sends notification of memory erasure to the verifier device.

Abstract: A system and method for building and assembling parts of or entire modular structures such as dwelling units, marine structures or watercraft from recycled PET material panels. Each assembly is made from panels of recycled PET material having a core and a rigid skin on both faces of the panel. The panels are joined together with splines of the same type of panel material. The splines may be glued and or fastened in place. The panels provide the necessary rigidity and insulative qualities for construction and watercraft manufacture and may be painted. The panels are impervious to environmental elements as well as to insects.

Abstract: The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof: wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-?-lactamase enzymes, in combination with antibiotics.

Abstract: A device for removing material from a vasculature includes a rotation subassembly having a first central axis and a first gear, a valve subassembly having the first central axis and being adjacent to the rotation subassembly, and an actuation system having a second central axis and a second gear. The rotation subassembly is coupled to a catheter to rotate the catheter. The valve subassembly is configured to selectively allow flow of the material from the catheter to the device. The actuation system configured to actuate rotation of the rotation subassembly. The first central axis and the second central axis are parallel.

Abstract: New material compositions, designs and configurations for components for an apparatus that produces a neutron flux such as a nuclear fusion reactor, and methods of manufacturing said new components.

Abstract: Systems, methods, and computer-program products for a dynamic detection threshold for a sensor of an autonomous vehicle are disclosed. A system may include a LIDAR system of an autonomous vehicle. The LiDAR system may include at least one light emitter and at least one light detector to generate analog output signals based on reflected pulses of light. A comparator may receive the analog output signals from the light detector and generate digital output signals based on the analog output signals and a threshold. A controller may receive a first digital output signal of the digital output signals from the comparator based on the threshold, adjust the threshold, receive at least one further digital output signal of the digital output signals from the comparator based on the threshold as adjusted, and/or determine at least one aggregation based on the first digital output signal and the further digital output signal(s).

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing.

Abstract: In various embodiments, a workflow application generates and evaluates designs that reflect stylistic preferences. In operation, the workflow application determines a target style based on input received via a graphical user interface (GUI). Notably, the target style characterizes a first set of designs. The workflow application then generates stylized design(s) based on stylization algorithm(s) associated with the target style. Subsequently, the workflow application, displays a subset of the stylized design(s) via the GUI. A stylized design included in the subset of stylized design(s) is ultimately selected for production via the GUI. Advantageously, because the workflow application can substantially increase the number of designs that can be generated and evaluated based on the target style in a given amount of time, relative to more manual prior art techniques, the overall quality of the stylized design selected for production can be improved.

Abstract: This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: New breeder blanket designs and configurations for use in a nuclear fusion reactor to breed Tritium fuel are presented. The breeder blanket designs consist of steel conduits made of different sections, formed of different steels, which are used for the circulation of liquid breeder material.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing.

Abstract: The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof: wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-?-lactamase enzymes, in combination with antibiotics.

Abstract: Neutron shielding comprising a metal-hydride metal composite: the metal-hydride metal composite comprising: a metal matrix; and a plurality of metal-hydride particles dispersed within the metal matrix; wherein, the fraction of metal-hydride in the metal-hydride metal composite is at least 1 mol % and the volume fraction of metal-hydride in the metal hydride metal composite is no higher than the ratio of the solid solubility limit of hydrogen in the metal matrix and the molar fraction of hydrogen in the metal-hydride.