Patents by Inventor Thomas Dinkel

Thomas Dinkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Demethylation of 14-hydroxy substituted alkaloid derivatives
    Patent number: 8158793
    Abstract: The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC—N?N—COOR2 in a suitable solvent.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: April 17, 2012
    Assignee: Siegfried Ltd.
    Inventors: Erik Heinz Lauterbach, Thomas Dinkel, Sabrina Heller, Andreas Bertogg
  • Process for the preparation of quaternary N-alkyl morphin or morphinan alkaloid derivatives
    Patent number: 8101756
    Abstract: The present invention relates to a process for the preparation of quaternary N-alkyl morphin or morphinan alkaloid derivatives. This is achieved by using a nucleophilic nitrogen, phosphor or sulfur containing base in the reaction mixture.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: January 24, 2012
    Assignee: Siegfried Ltd.
    Inventors: Martin Eipert, Erik Heinz Lauterbach, Sabrina Heller, Thomas Dinkel, Stephanie Hake
  • Demethylation of 14-hydroxy substituted alkaloid derivatives
    Patent number: 7619088
    Abstract: The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC—N?N—COOR2 in a suitable solvent.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: November 17, 2009
    Assignee: Siegfried Ltd.
    Inventors: Erik Heinz Lauterbach, Thomas Dinkel, Sabrina Heller
  • Demethylation of 14-hydroxy substituted alkaloid derivatives
    Publication number: 20090163717
    Abstract: The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC—N?N—COOR2 in a suitable solvent.
    Type: Application
    Filed: November 24, 2008
    Publication date: June 25, 2009
    Inventors: Erik Heinz Lauterbach, Thomas Dinkel, Sabrina Heller, Andreas Bertogg
  • Demethylation of 14 hydroxy substituted alkaloid derivatives
    Publication number: 20090137809
    Abstract: The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC—N?N—COOR2 in a suitable solvent.
    Type: Application
    Filed: October 29, 2008
    Publication date: May 28, 2009
    Applicant: SIEGFRIED Ltd
    Inventors: Erik Heinz Lauterbach, Thomas Dinkel, Sabrina Heller
  • Process for the preparation of quaternary N-alkyl morphin or morphinan alkaloid derivatives
    Publication number: 20090054651
    Abstract: The present invention relates to a process for the preparation of quaternary N-alkyl morphin or morphinan alkaloid derivatives. This is achieved by using a nucleophilic nitrogen, phosphor or sulfur containing base in the reaction mixture.
    Type: Application
    Filed: July 18, 2008
    Publication date: February 26, 2009
    Inventors: Martin Eipert, Erik Heinz Lauterbach, Sabrina Heller, Thomas Dinkel, Stephanie Hake