Patents by Inventor Thomas Dschietzig

Thomas Dschietzig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10842851
    Abstract: A pharmaceutical composition for treatment for of r afflicted or in risk of becoming of impaired glucose tolerance (IGT) and/or type-2 it comprising an effective amount of relaxin for protecting beta-cells and beta-cell function against the effects of high blood glucose (glucotoxicity). Treatment of persons of disglycaemias, and protection of beta cells of the islets of Langerhans and beta-cell function in patients having type-2 diabetes, is diclosed.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: November 24, 2020
    Assignee: Immundiagnostik AG
    Inventor: Thomas Dschietzig
  • Publication number: 20160287672
    Abstract: The present disclosure relates to methods for treating human subjects afflicted with chronic heart failure. The methods described herein employ administration of relaxin.
    Type: Application
    Filed: April 25, 2016
    Publication date: October 6, 2016
    Inventors: Elaine Unemori, Sam Teichman, Thomas Dschietzig, Dennis R. Stewart, Martha Jo Whitehouse
  • Patent number: 9434780
    Abstract: A process for preparing human relaxin-2 having the following amino acid sequence: A chain: (SEQ?ID?NO:?1) pGlu-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His- Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys B chain: (SEQ?ID?NO:?2) Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly- Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly- Met-Ser-Thr-Trp-Ser; comprising the following steps: providing the amino acids necessary for the synthesis of the A and B chains with usual protective groups, wherein the cysteines are employed as trityl-protected amino acids (L-Cys(Trt)-OH); effecting a chromatographic purification of the individual chains A and B after the solid state synthesis; followed by the simultaneous folding and combination of the individual chains A and B in ammonium hydrogencarbonate buffer at pH 7.9 to 8.4; and subsequent purification of the relaxin-2 formed.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: September 6, 2016
    Assignee: Relaxera Pharma GmbH & Co. KG i.G.
    Inventors: Wolf-Georg Forssmann, Thomas Dschietzig, Ludger Ständker, Andreas Zgraja, Jochen Hirsch
  • Publication number: 20150038411
    Abstract: A pharmaceutical composition for treatment for of r afflicted or in risk of becoming of impaired glucose tolerance (IGT) and/or type-2 it comprising an effective amount of relaxin for protecting beta-cells and beta-cell function against the effects of high blood glucose (glucotoxicity). Treatment of persons of disglycaemias, and protection of beta cells of the islets of Langerhans and beta-cell function in patients having type-2 diabetes, is diclosed.
    Type: Application
    Filed: February 22, 2013
    Publication date: February 5, 2015
    Applicant: Immundiagnostik AG
    Inventor: Thomas Dschietzig
  • Publication number: 20140328900
    Abstract: A process for preparing human relaxin-2 having the following amino acid sequence: A chain: (SEQ?ID?NO:?1) pGlu-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His- Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys B chain: (SEQ?ID?NO:?2) Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly- Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly- Met-Ser-Thr-Trp-Ser; comprising the following steps: providing the amino acids necessary for the synthesis of the A and B chains with usual protective groups, wherein the cysteines are employed as trityl-protected amino acids (L-Cys(Trt)-OH); effecting a chromatographic purification of the individual chains A and B after the solid state synthesis; followed by the simultaneous folding and combination of the individual chains A and B in ammonium hydrogencarbonate buffer at pH 7.9 to 8.4; and subsequent purification of the relaxin-2 formed.
    Type: Application
    Filed: August 3, 2012
    Publication date: November 6, 2014
    Applicant: PHARIS BIOTEC GMBH
    Inventors: Wolf-Georg Forssmann, Thomas Dschietzig, Ludger Ständker, Andreas Zgraja, Jochen Hirsch
  • Publication number: 20140005112
    Abstract: The present disclosure relates to methods for treating human subjects afflicted with chronic heart failure. The methods described herein employ administration of relaxin.
    Type: Application
    Filed: July 11, 2013
    Publication date: January 2, 2014
    Inventors: Elaine Unemori, Sam Teichman, Thomas Dschietzig, Dennis R. Stewart, Martha Jo Whitehouse
  • Publication number: 20110144019
    Abstract: The present disclosure relates to methods for treating human subjects afflicted with chronic heart failure. The methods described herein employ administration of relaxin.
    Type: Application
    Filed: May 15, 2009
    Publication date: June 16, 2011
    Inventors: Elaine Unemori, Sam L. Teichman, Thomas Dschietzig, Dennis R. Stewart, Martha J. Whitehouse