Patents by Inventor Thomas Durek

Thomas Durek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATION OF PEPTIDES
    Publication number: 20190225652
    Abstract: The present disclosure relates generally to generation of a recombinant enzyme with cyclization activity and its use for generating cyclic peptides as well as linear peptide conjugates.
    Type: Application
    Filed: September 23, 2016
    Publication date: July 25, 2019
    Inventors: Karen Sandra Harris, Marilyn Anne Anderson, Thomas Matthew Alcorn Shafee, Thomas Durek, Mark Jackson, David Craik
  • Convergent synthesis of proteins by kinetically controlled ligation
    Patent number: 7674881
    Abstract: The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: March 9, 2010
    Assignee: The University of Chicago
    Inventors: Stephen Kent, Brad Pentelute, Duhee Bang, Erik Johnson, Thomas Durek
  • Convergent synthesis of proteins by kinetically controlled ligation
    Publication number: 20070082378
    Abstract: The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.
    Type: Application
    Filed: October 10, 2006
    Publication date: April 12, 2007
    Applicant: University of Chicago
    Inventors: Stephen Kent, Duhee Bang, Brad Pentelute, Thomas Durek, Erik Johnson