Patents by Inventor Thomas Durig
Thomas Durig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240020529Abstract: Present invention is directed to an artificial intelligence-based method and a system, that uses both experimental results data and molecular simulation to predict properties of amorphous solid dispersions such as glass transition temperature, dissolution profile, and/or physical stability. The method and system of the present invention enable rational design of amorphous solid dispersions for poorly water-soluble drugs and significantly reduce the time and resource required for amorphous solid dispersions formulation development.Type: ApplicationFiled: October 27, 2021Publication date: January 18, 2024Applicant: ISP INVESTMENTS LLCInventors: Yunxia BI, Thomas DURIG, Solomon Howard JACOBSON
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Publication number: 20210347978Abstract: A peroxide stable polymer composition comprises a mixture of polyvinylpyrrolidone/vinyl acetate copolymer (PVP/VA) and butylated hydroxy anisole (BHA), an antioxidant. Products or applications comprising said stable polymer composition and a process for the preparation thereof are disclosed in the present application.Type: ApplicationFiled: September 17, 2019Publication date: November 11, 2021Applicant: ISP INVESTMENTS LLCInventors: Thomas DURIG, Paul C. GILLETTE, Michael A. TALLON
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Patent number: 10596261Abstract: The present invention provides a coprocessed excipient composition and a method of producing the same. The coprocessed excipient comprises vinyl lactam derived polymer and a deagglomerated coprocessing agent. The coprocessing agent is fumed silica, colloidal silica or silicon dioxide. The coprocessed excipient is prepared by a continuous process and has a Brookfield cohesion of less than 0.12 kPa, a bulk density of at least 0.249 gram/milliliter and a flow property as measured by Johanson flow rate number increase from 1.1 to 5.0 fold.Type: GrantFiled: March 12, 2014Date of Patent: March 24, 2020Inventors: Divya Tewari, Yevgeniya A. Titova, Brad Beissner, Thomas Durig
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Patent number: 10172944Abstract: An excipient composition having good bulk density and improved flow characteristics is provided. The present invention particularly provides a coprocessed excipient composition and a method of producing the same. The coprocessed excipient comprises cellulose derived polymer and a deagglomerated coprocessing agent. The coprocessing agent is fumed silica, colloidal silica or silicon dioxide. The coprocessed excipient is prepared in a continuous process and has excellent compactability and improved flow property as measured by Johanson flow rate number increase from 1.1 to 5.0 fold, is characterized by a Brookfield cohesion factor of less than 0.2 kPa and a bulk density of at least 0.249 g/ml.Type: GrantFiled: March 12, 2014Date of Patent: January 8, 2019Assignee: ISP INVESTMENTS LLCInventors: Divya Tewari, Yevgeniya A. Titova, Brad Beissner, Thomas Durig
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Publication number: 20160120989Abstract: An excipient composition having good bulk density and improved flow characteristics is provided. The present invention particularly provides a coprocessed excipient composition and a method of producing the same. The coprocessed excipient comprises cellulose derived polymer and a deagglomerated coprocessing agent. The coprocessing agent is fumed silica, colloidal silica or silicon dioxide. The coprocessed excipient is prepared in a continuous process and has excellent compactability and improved flow property as measured by Johanson flow rate number increase from 1.1 to 5.0 fold, is characterized by a Brookfield cohesion factor of less than 0.2 kPa and a bulk density of at least 0.249 g/ml.Type: ApplicationFiled: March 12, 2014Publication date: May 5, 2016Applicant: ISP INVESTMENTS INC.Inventors: Divya TEWARI, Yevgeniya A. TITOVA, Brad BEISSNER, Thomas DURIG
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Publication number: 20150359895Abstract: The present invention provides a coprocessed excipient composition and a method of producing the same. The coprocessed excipient comprises vinyl lactam derived polymer and a deagglomerated coprocessing agent. The coprocessing agent is fumed silica, colloidal silica or silicon dioxide. The coprocessed excipient is prepared by a continuous process and has a Brookfield cohesion of less than 0.12 kPa, a bulk density of at least 0.249 gram/milliliter and a flow property as measured by Johanson flow rate number increase from 1.1 to 5.0 fold.Type: ApplicationFiled: March 12, 2014Publication date: December 17, 2015Applicant: ISP INVESTMENTS INC.Inventors: Divya TEWARI, Yevgeniya A. TITOVA, Brad BEISSNER, Thomas DURIG
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Patent number: 9114170Abstract: A stable and high loading ternary solid dispersion composition comprising (a) about 50% wt. to about 90% wt. of amorphous Efavirenz; (b) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone (PVP), a first polymer; (c) about 1% wt. to about 30% wt. of a water-soluble second polymer; and (d) optionally about 0.1% wt. to about 50% wt. of at least one pharmaceutically acceptable excipient. Also discloses a high loading ternary composition comprising (a) a solid dispersion composition comprising (i) about 50% wt. to about 90% wt. of amorphous Efavirenz; (ii) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone, a first polymer; (b) about 1% wt. to about 30% wt. of a water-soluble second polymer blended with solid dispersion of composition of (a); and (c) optionally about 0.1% wt. to about 50% wt. of at least one pharmaceutically acceptable excipient.Type: GrantFiled: March 15, 2013Date of Patent: August 25, 2015Assignee: ISP INVESTMENTS INC.Inventors: Yunxia Bi, Mohammed Abdul Rahman, James David Lester, Thomas Durig, Randy Bull
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Patent number: 8968456Abstract: The present invention relates to a film coating composition used for film coating pharmaceutical tablets, nutritional supplements, confectionary forms and the like. The film coating composition comprises a water soluble film former such as hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, starches, modified starches and the like and one or more hydrophobic compounds, such as metal salt of higher fatty acids, higher fatty alcohol, natural wax either from vegetable, animal origin or synthetic wax. Optionally, the film coating composition may include plasticizers, colorants, such as pigments and/or flow aids.Type: GrantFiled: August 26, 2010Date of Patent: March 3, 2015Assignee: Hercules IncorporatedInventors: Thomas Durig, Divya Tewari
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Publication number: 20110048281Abstract: The present invention relates to a film coating composition used for film coating pharmaceutical tablets, nutritional supplements, confectionary forms and the like. The film coating composition comprises a water soluble film former such as hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, starches, modified starches and the like and one or more hydrophobic compounds, such as metal salt of higher fatty acids, higher fatty alcohol, natural wax either from vegetable, animal origin or synthetic wax. Optionally, the film coating composition may include plasticizers, colorants, such as pigments and/or flow aids.Type: ApplicationFiled: August 26, 2010Publication date: March 3, 2011Applicant: HERCULES INCORPORATEDInventors: Thomas DURIG, Divya TEWARI
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Publication number: 20110002986Abstract: The present invention relates to formulations for use as enteric coatings. More particularly, the present invention relates to a formulation comprising a blend of food grade ingredients that can be readily dispersed in water. This dispersion exhibits low viscosity and can easily be coated onto solid dosage forms through spraying and the like to provide an enteric coating on the solid dosage form.Type: ApplicationFiled: July 1, 2010Publication date: January 6, 2011Applicant: Hercules IncorporatedInventors: Thomas Durig, Yuda Zong
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Publication number: 20090252767Abstract: The present invention relates to formulations for use as enteric coatings. More particularly, the present invention relates to a formulation comprising a dry blend of food grade ingredients that can be readily dispersed in water. This dispersion exhibits low viscosity and can easily be coated onto solid dosage forms through spraying and the like to provide an enteric coating on the solid dosage form.Type: ApplicationFiled: November 13, 2008Publication date: October 8, 2009Inventors: Thomas Durig, Derek Ronell Malone, Yuda Zong
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Publication number: 20080305166Abstract: A rapidly disintegrating, orally administered tablet or compressed dosage form, comprising ethylcellulose (EC) as a directly compressible binder which enhances tablet robustness as manifested by improved strength, lower friability, lower hygroscopicity and yet, hydrophobic nature notwithstanding, does not retard disintegration, but shortens disintegration time or is disintegration time neutral when co-formulated with disintegrants and other water-soluble excipients such as sugar alcohols.Type: ApplicationFiled: May 8, 2008Publication date: December 11, 2008Inventor: Thomas Durig
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Patent number: 7229642Abstract: Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.Type: GrantFiled: June 22, 2005Date of Patent: June 12, 2007Assignee: Scolr, Inc.Inventors: A. Reza Fassihi, Thomas Dürig
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Publication number: 20050238717Abstract: Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.Type: ApplicationFiled: June 22, 2005Publication date: October 27, 2005Inventors: A. Fassihi, Thomas Dürig
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Patent number: 6936275Abstract: Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.Type: GrantFiled: February 11, 2003Date of Patent: August 30, 2005Assignee: Scolr, Inc.Inventors: A. Reza Fassihi, Thomas Dürig
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Publication number: 20030219480Abstract: Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.Type: ApplicationFiled: February 11, 2003Publication date: November 27, 2003Inventors: A. Reza Fassihi, Thomas Durig
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Patent number: 6592901Abstract: A pharmaceutical dosage form composition is composed of an ethylcellulose that has an ethoxyl range lower limit of 49.6%, an a viscosity of less than 53 cps and at least one active pharmaceutical ingredient. This dosage form is highly compressible and compactible forming harder tables or pellets with better release retardation than comparable prior art tablets.Type: GrantFiled: October 15, 2001Date of Patent: July 15, 2003Assignee: Hercules IncorporatedInventors: Thomas Durig, Ronald Haywood Hall, Richard A. Salzstein
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Publication number: 20030077327Abstract: A pharmaceutical dosage form composition is composed of an ethylcellulose that has an ethoxyl range lower limit of 49.6%, an a viscosity of less than 53 cps and at least one active pharmaceutical ingredient. This dosage form is highly compressible and compactible forming harder tables or pellets with better release retardation than comparable prior art tablets.Type: ApplicationFiled: October 15, 2001Publication date: April 24, 2003Inventors: Thomas Durig, Ronald Haywood Hall, Richard A. Salzstein
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Patent number: 6517868Abstract: Disclosed herein is a tableted oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.Type: GrantFiled: November 30, 2001Date of Patent: February 11, 2003Inventors: A. Reza Fassihi, Thomas Dürig
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Publication number: 20020061332Abstract: Disclosed herein is a tableted oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.Type: ApplicationFiled: November 30, 2001Publication date: May 23, 2002Inventors: A. Reza Fassihi, Thomas Durig