Patents by Inventor Thomas Dyrmann Leser
Thomas Dyrmann Leser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10022408Abstract: The present invention relates to novel isolated strains of Bifidobacterium adolescentis which are capable of i) increasing the trans-epithelial electrical resistance (TER) of a Caco-2 cell monolayer after 10 h treatment to more than 120% of TER at treatment start, ii) inducing secretion of >200 pg/ml of IL-10, and/or iii) inducing an IL-10:IL-12 ratio >1 when co-incubated with human PBMC derived dendritic cells. The strains may have one, two or all three of these capabilities. The present invention relates to the use of these novel strains for the in prevention, alleviation of symptoms, and treatment of diseases or conditions with an underlying impaired intestinal barrier function and pro-inflammatory activation of the mucosa.Type: GrantFiled: August 28, 2015Date of Patent: July 17, 2018Assignee: CHR. Hansen A/SInventors: Thomas Dyrmann Leser, Dorte Myling-Petersen, Jeffrey Earl Christensen, Anja Wellejus, Elke Brockmann
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Publication number: 20170252382Abstract: The present invention relates to novel isolated strains of Bifidobacterium adolescentis which are capable of i) increasing the trans-epithelial electrical resistance (TER) of a Caco-2 cell monolayer after 10 h treatment to more than 120% of TER at treatment start, ii) inducing secretion of >200 pg/ml of IL-10, and/or iii) inducing an IL-10:IL-12 ratio>1 when co-incubated with human PBMC derived dendritic cells. The strains may have one, two or all three of these capabilities. The present invention relates to the use of these novel strains for the in prevention, alleviation of symptoms, and treatment of diseases or conditions with an underlying impaired intestinal barrier function and pro-inflammatory activation of the mucosa.Type: ApplicationFiled: August 28, 2015Publication date: September 7, 2017Applicant: CHR. HANSEN A/SInventors: THOMAS DYRMANN LESER, Dorte MYLING-PETERSEN, Jeffrey Earl CHRISTENSEN, Anja WELLEJUS, Elke BROCKMANN
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Publication number: 20160129055Abstract: Regarding Deposited Microbial Organisms [EXPERT SOLUTION] For all deposited microbial organisms mentioned in the present patent application and which not are in collections open to the public the so-called expert solution is requested. In respect to those designations in which a European Patent is sought a sample of the deposited microorganism will be made available until the publication of the mention of the grant of the European patent or until the date on which application has been refused or withdrawn or is deemed to be withdrawn, only by the issue of such a sample to an expert nominated by the person requesting the sample, and approved either i) by the Applicant and/or ii) by the European Patent Office, whichever applies.Type: ApplicationFiled: November 6, 2015Publication date: May 12, 2016Applicant: Chr. Hansen A/SInventors: Jens KILDSGAARD, Thomas Dyrmann LESER, Thomas GUNNARSSON, Mette WEISE, Ditte Marie FOLKENBERG, Thomas JANZEN, Benedicte FLAMBARD
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Publication number: 20140370146Abstract: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by producing a compound of interest. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.Type: ApplicationFiled: May 21, 2014Publication date: December 18, 2014Applicant: Chr. Hansen A/SInventors: Inge KNAP, Ane KNARREBORG, Thomas Dyrmann LESER, Lund BENTE, Mette Dines CANTOR, Patrick DERKX
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Patent number: 8802079Abstract: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by producing a compound of interest. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.Type: GrantFiled: December 16, 2009Date of Patent: August 12, 2014Assignee: Chr. Hansen A/SInventors: Inge Knap, Ane Knarreborg, Thomas Dyrmann Leser, Lund Bente, Mette Dines Cantor, Patrick Derkx
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Patent number: 8741280Abstract: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of essential amino acid. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.Type: GrantFiled: December 16, 2009Date of Patent: June 3, 2014Assignee: Chr. Hansen A/SInventors: Mette Dines Cantor, Patrick Derkx, Inge Knap, Ane Knarreborg, Thomas Dyrmann Leser, Lund Bente
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Patent number: 8642305Abstract: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of phytase. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.Type: GrantFiled: November 14, 2012Date of Patent: February 4, 2014Assignee: Chr. Hansen A/SInventors: Inge Knap, Ane Knarreborg, Thomas Dyrmann Leser, Bente Lund
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Publication number: 20130336942Abstract: The use of probiotic bacteria that modulate expression of a number of satiety markers in the intestine and reduces fat deposition to promote an optimal body weight of a mammal is described. The invention further relates to a composition comprising such a probiotic strain of bacteria and/or a fraction of said strain and/or metabolite of said strain for the preparation of a composition for administration to a mammal for promoting an optimal body weight of a mammal.Type: ApplicationFiled: May 22, 2013Publication date: December 19, 2013Inventors: Thomas Dyrmann Leser, Thomas GUNNARSSON, Jens KILDSGAARD, Janni Wandahl PEDERSEN, Bénédicte FLAMBARD
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Patent number: 8334123Abstract: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of phytase. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.Type: GrantFiled: June 11, 2008Date of Patent: December 18, 2012Assignee: Chr. Hansen A/SInventors: Inge Knap, Ane Knarreborg, Thomas Dyrmann Leser, Bente Lund
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Publication number: 20120027737Abstract: The invention relates to the use of a composition comprising probiotic bacteria that regulate expression of key components involved in diet-induced insulin resistance for ameliorating or preventing diet-induced insulin resistance. The use of the probiotic strain and/or a fraction of said strain and/or metabolite of said strain for the manufacture of a medicament or a food or feed product to ameliorate diet-induced insulin resistance and help to obtain optimal body weight of a mammal is disclosed.Type: ApplicationFiled: March 19, 2010Publication date: February 2, 2012Inventors: Thomas Dyrmann Leser, Thomas Gunnarsson, Jens Kildsgaard, Janni Wandahl Pedersen, Bénédicte Flambard
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Publication number: 20120020944Abstract: The use of probiotic bacteria that modulate expression of a number of satiety markers in the intestine and reduces fat deposition to promote an optimal body weight of a mammal is described. The invention further relates to a composition comprising such a probiotic strain of bacteria and/or a fraction of said strain and/or metabolite of said strain for the preparation of a composition for administration to a mammal for promoting an optimal body weight of a mammal.Type: ApplicationFiled: March 24, 2010Publication date: January 26, 2012Inventors: Thomas Dyrmann Leser, Thomas Gunnarsson, Jens Kildsgaard, Janni Wandahl Pedersen, Bénédicte Flambard
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Publication number: 20120003351Abstract: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of essential amino acid. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.Type: ApplicationFiled: December 16, 2009Publication date: January 5, 2012Inventors: Mette Dines Cantor, Patrick Derkx, Inge Knap, Ane Knarreborg, Thomas Dyrmann Leser, Lund Bente
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Publication number: 20110262584Abstract: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by producing a compound of interest. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.Type: ApplicationFiled: December 16, 2009Publication date: October 27, 2011Inventors: Inge Knap, Ane Knarreborg, Thomas Dyrmann Leser, Lund Bente, Mette Dines Cantor, Patrick Derkx
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Publication number: 20110177034Abstract: The invention relates to novel, probiotic, anti-inflammatory strains of Bifidobacterium longum, their use for treatment of diseases, and for preparation of human or pet food or pharmaceutical compositions. The strains produce high amounts of exopolysaccharides with a high content of mannose- and glucose residues. Accordingly, the invention also relates to a bacterial polysaccharide composition obtained from the strains, their use for treatment of diseases, and pharmaceutical compositions comprising such polysaccharides.Type: ApplicationFiled: July 6, 2009Publication date: July 21, 2011Inventors: Jens Kildsgaard, Thomas Dyrmann Leser, Thomas Gunnarsson, Mette Weise, Ditte Marie Folkenberg, Thomas Janzen, Benedicte Flambard
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Publication number: 20100247706Abstract: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of phytase. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.Type: ApplicationFiled: June 11, 2008Publication date: September 30, 2010Inventors: Inge Knap, Ane Knarreborg, Thomas Dyrmann Leser, Bente Lund