Patents by Inventor Thomas E. ANGEL

Thomas E. ANGEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEASUREMENT OF PROTEIN MOLECULAR FLUX RATES BY QUANTIFYING ISOTOPOLOGUE ABUNDANCES IN IMMONIUM ION USING HIGH RESOLUTION MASS SPECTROMETRY
    Publication number: 20200232995
    Abstract: Provided herein are methods for measuring a molecular flux rate proteins and polypeptides based on analysis of isotopologue abundances of immonium ion fragments within a mass isotopomer using a high resolution mass spectrometric measurement. Such methods may be used, inter alia, to calculate a fraction of newly synthesized protein or polypeptide molecules of interest, a replacement rate of target molecules of interest, and/or a rate of breakdown or degradation of target molecules of interest, e.g., based on isotopologue relative abundances.
    Type: Application
    Filed: September 7, 2016
    Publication date: July 23, 2020
    Applicant: KineMed, Inc.
    Inventors: Marc K. HELLERSTEIN, Thomas E. ANGEL, Alexander A. MAKAROV
  • MEASUREMENT OF MOLECULAR FLUX RATES BY QUANTIFYING ISOTOPOLOGUE ABUNDANCES USING HIGH RESOLUTION MASS SPECTROMETRY
    Publication number: 20180259531
    Abstract: Provided herein are methods for measuring a molecular flux rate based on analysis of isotopologue abundance within a mass isotopomer, e.g., using a high resolution mass spectrometric measurement. Such methods may be used, inter alia, to calculate a fraction of newly synthesized target molecules of interest, a replacement rate of target molecules of interest, and/or a rate of breakdown or degradation of target molecules of interest, e.g., based on isotopologue relative abundance.
    Type: Application
    Filed: September 7, 2016
    Publication date: September 13, 2018
    Applicant: KineMed, Inc.
    Inventors: Marc K. HELLERSTEIN, Thomas E. ANGEL