Patents by Inventor Thomas E. Daley

Thomas E. Daley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180098964
    Abstract: Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of geneic subpopulations expressing specific polymorphisms of the alcohol dehydrogenase and aldehyde dehydrogenase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these sub-populations.
    Type: Application
    Filed: October 19, 2017
    Publication date: April 12, 2018
    Inventors: Thomas E. DALEY, Elizabeth C. SQUIERS, Kin-Hung P. YU
  • Publication number: 20170007578
    Abstract: Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of genetic subpopulations expressing specific polymorphisms of the alcohol dehydrogenase and aldehyde dehydro genase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these subpopulations.
    Type: Application
    Filed: September 20, 2016
    Publication date: January 12, 2017
    Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung P. Yu
  • Publication number: 20160243082
    Abstract: Provided herein are methods, compositions and formulations to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by acetaldehyde accumulation, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity.
    Type: Application
    Filed: May 2, 2016
    Publication date: August 25, 2016
    Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
  • Publication number: 20160151332
    Abstract: Provided herein are 4-methylpyrazole (4-MP) formulations, stable under storage conditions of up to about 55° C.
    Type: Application
    Filed: October 30, 2015
    Publication date: June 2, 2016
    Inventors: Thomas E. Daley, Kathy Powell, Olga Jarzebinski
  • Patent number: 9326971
    Abstract: Provided herein are methods, compositions and formulations to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by acetaldehyde accumulation, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: May 3, 2016
    Assignee: RAPTOR PHARMACEUTICALS INC.
    Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
  • Patent number: 9173850
    Abstract: Provided herein are 4-methylpyrazole (4-MP) formulations, stable under storage conditions of up to about 55° C.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: November 3, 2015
    Assignee: RAPTOR PHARMACEUTICALS INC.
    Inventors: Thomas E. Daley, Kathy Powell, Olga Jarzebinski
  • Publication number: 20140155450
    Abstract: Provided herein are methods, compositions and formulations to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by acetaldehyde accumulation, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity.
    Type: Application
    Filed: February 5, 2014
    Publication date: June 5, 2014
    Applicant: Raptor Pharmaceuticals Inc.
    Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
  • Patent number: 8440632
    Abstract: Provided herein are ginsenoside compositions comprising at least 10% (w/w) of a protopanaxadiol type of ginsenoside suitable for administration to a subject. Also provided are methods using the ginsenoside compositions for reducing acetaldehyde concentrations, preventing or ameliorating a symptom of elevated acetaldehyde concentration, or reducing the risk of diseases or disorders caused by the intake of ethyl alcohol.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: May 14, 2013
    Assignee: Raptor Therapeutics Inc.
    Inventors: Thomas E. Daley, Michael Tempesta
  • Publication number: 20120322843
    Abstract: Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of genetic subpopulations expressing specific polymorphisms of the alcohol dehydrogenase and aldehyde dehydrogenase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these subpopulations.
    Type: Application
    Filed: June 21, 2012
    Publication date: December 20, 2012
    Applicant: RAPTOR THERAPEUTICS INC.
    Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
  • Publication number: 20120252857
    Abstract: Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of genetic subpopulations expressing specific polymorphisms of the alcohol dehydrogenase and aldehyde dehydrogenase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these subpopulations.
    Type: Application
    Filed: June 9, 2010
    Publication date: October 4, 2012
    Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
  • Publication number: 20120244217
    Abstract: Provided herein are 4-methylpyrazole (4-MP) formulations, stable under storage conditions of up to about 55° C.
    Type: Application
    Filed: December 6, 2010
    Publication date: September 27, 2012
    Inventors: Thomas E. Daley, Kathy Powell, Olga Jarzebinski
  • Publication number: 20110065659
    Abstract: Provided herein are ginsenoside compositions comprising at least 10% (w/w) of a protopanaxadiol type of ginsenoside suitable for administration to a subject. Also provided are methods using the ginsenoside compositions for reducing acetaldehyde concentrations, preventing or ameliorating a symptom of elevated acetaldehyde concentration, or reducing the risk of diseases or disorders caused by the intake of ethyl alcohol.
    Type: Application
    Filed: January 23, 2009
    Publication date: March 17, 2011
    Inventors: Thomas E. Daley, Michael Tempesta
  • Publication number: 20110053999
    Abstract: Provided herein are methods, compositions and formulations to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by acetaldehyde accumulation, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity.
    Type: Application
    Filed: June 9, 2010
    Publication date: March 3, 2011
    Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
  • Publication number: 20080021083
    Abstract: Methods, articles of manufacture and compositions are provided useful for the prevention or amelioration of a symptom of acetaldehyde accumulation or ethanol intolerance in a subject with reduced or absent reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity wherein about 1 mg/kg to about 4 mg/kg 4-methylpyrazole, or an equivalent mass of a 4-MP salt, are to be orally administered to the subject.
    Type: Application
    Filed: March 3, 2005
    Publication date: January 24, 2008
    Inventor: Thomas E. Daley