Patents by Inventor Thomas E. Goodwin

Thomas E. Goodwin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240294477
    Abstract: Disclosed herein are compounds, 3,4,6,8-substituted-2-([1,1?-biphenyl]-4-yl)quinoline analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH) with improved pharmacokinetic properties. The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. The disclosed compounds can demonstrate flip-flop kinetics when administered orally, i.e., pharmacokinetics in which the rate of absorption, rather than the rate of elimination, dominates the pharmacokinetics. The disclosed compounds can demonstrate a sustained pharmacokinetic profile instead of an immediate release profile. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Application
    Filed: April 26, 2024
    Publication date: September 5, 2024
    Inventors: John C. BYRD, Thomas E. GOODWIN, Ola ELGAMAL, Erin HERTLEIN, Mouad ABDULRAHIM, Chad E. BENNETT, Sandip Madhukar VIBHUTE
  • Patent number: 11999697
    Abstract: Disclosed herein are compounds, 3,4,6,8-substituted-2-([1,1?-biphenyl]-4-yl)quinoline analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH) with improved pharmacokinetic properties. The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. The disclosed compounds can demonstrate flip-flop kinetics when administered orally, i.e., pharmacokinetics in which the rate of absorption, rather than the rate of elimination, dominates the pharmacokinetics. The disclosed compounds can demonstrate a sustained pharmacokinetic profile instead of an immediate release profile. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: June 4, 2024
    Assignees: OHIO STATE INNOVATION FOUNDATION, HENDRIX COLLEGE
    Inventors: John C. Byrd, Thomas E. Goodwin, Ola Elgamal, Erin Hertlein, Mouad Abdulrahim, Chad E. Bennett, Sandip Madhukar Vibhute
  • Publication number: 20240018108
    Abstract: Disclosed herein are compounds, 6-substituted-2-([1,1?-biphenyl]-4-yl)quinoline-4-carboxylic acid analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH) with improved pharmacokinetic properties. The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. The disclosed compounds can demonstrate flip-flop kinetics when administered orally, i.e., pharmacokinetics in which the rate of absorption, rather than the rate of elimination, dominates the pharmacokinetics. The disclosed compounds can demonstrate a sustained pharmacokinetic profile instead of an immediate release profile.
    Type: Application
    Filed: December 26, 2020
    Publication date: January 18, 2024
    Inventors: John C. BYRD, Chad E. BENNETT, Sandip Madhukar VIBHUTE, Thomas E. GOODWIN, Erin HERTLEIN, Ola A. ELGAMAL, Tyler Aron WILSON
  • Publication number: 20230303710
    Abstract: Disclosed are pharmaceutical combinations and methods of treating a clinical condition, e.g., AML, by administering to a subject a pharmaceutical combination comprising a DHODH inhibitor and an anti-CD38 therapeutic agent such as a anti-CD38 antibody. The pharmaceutical combination can further comprise one or more additional therapeutic agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Application
    Filed: December 26, 2020
    Publication date: September 28, 2023
    Inventors: John C. BYRD, Erin HERTLEIN, Ola A. ELGAMAL, Mariah L. JOHNSON, Susheela TRIDANDAPANI, Chad E. BENNETT, Sandip Madhukar VIBHUTE, Thomas E. GOODWIN
  • Publication number: 20230109418
    Abstract: Disclosed herein are compounds, 6-substituted-2-(phenylheteroaryl)quinoline-4-carboxylic acid analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH). The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 6, 2023
    Inventors: John C. BYRD, Chad E. BENNETT, Sandip Madhukar VIBHUTE, Thomas E. GOODWIN, Erin HERTLEIN, Ola A. ELGAMAL, Tyler A. WILSON
  • Publication number: 20230089524
    Abstract: Disclosed herein are compounds, 6-substituted-2-(phenylheteroaryl)quinoline-4-carboxylic acid analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH). The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Application
    Filed: December 22, 2020
    Publication date: March 23, 2023
    Inventors: John C. BYRD, Chad E. BENNETT, Sandip Madhukar VIBHUTE, Thomas E. GOODWIN, Erin HERTLEIN, Ola A. ELGAMAL, Tyler A. WILSON
  • Patent number: 11312686
    Abstract: Disclosed herein are compounds, 3,4,6,8-substituted-2-([1?-biphenyl]-4-yl)quinoline analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH) with improved pharmacokinetic properties. The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. The disclosed compounds can demonstrate flip-flop kinetics when administered orally, i.e., pharmacokinetics in which the rate of absorption, rather than the rate of elimination, dominates the pharmacokinetics. The disclosed compounds can demonstrate a sustained pharmacokinetic profile instead of an immediate release profile. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: June 22, 2019
    Date of Patent: April 26, 2022
    Assignees: Ohio State Innovation Foundation, Hendrix College
    Inventors: John C. Byrd, Thomas E. Goodwin, Ola Elgamal, Erin Hertlein, Mouad Abdulrahim, Chad E. Bennett, Sandip Madhukar Vibhute
  • Publication number: 20220064119
    Abstract: Disclosed herein are compounds, 3,4,6,8-substituted-2-([1,1?-biphenyl]-4-yl)quinoline analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH) with improved pharmacokinetic properties. The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. The disclosed compounds can demonstrate flip-flop kinetics when administered orally, i.e., pharmacokinetics in which the rate of absorption, rather than the rate of elimination, dominates the pharmacokinetics. The disclosed compounds can demonstrate a sustained pharmacokinetic profile instead of an immediate release profile. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Application
    Filed: November 10, 2021
    Publication date: March 3, 2022
    Inventors: John C. BYRD, Thomas E. GOODWIN, Ola ELGAMAL, Erin HERTLEIN, Mouad ABDULRAHIM, Chad E. BENNETT, Sandip Madhukar VIBHUTE
  • Publication number: 20210253531
    Abstract: Disclosed herein are compounds, 3,4,6,8-substituted-2-([1?-biphenyl]-4-yl)quinoline analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH) with improved pharmacokinetic properties. The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. The disclosed compounds can demonstrate flip-flop kinetics when administered orally, i.e., pharmacokinetics in which the rate of absorption, rather than the rate of elimination, dominates the pharmacokinetics. The disclosed compounds can demonstrate a sustained pharmacokinetic profile instead of an immediate release profile. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Application
    Filed: June 22, 2019
    Publication date: August 19, 2021
    Inventors: John C. BYRD, Thomas E. GOODWIN, Ola ELGAMAL, Erin HERTLEIN, Mouad ABDULRAHIM, Chad E. BENNETT, Sandip Madhukar VIBHUTE
  • Patent number: 8545350
    Abstract: An expandable hunting arrowhead which ejects a signal generator and transmitter into the body of the quarry animal upon impact is described. The action of expanding blades, which rotate radially outwardly and backwardly to deploy from the sides of the arrowhead upon impact, separates the tip of the arrow containing the signal generator and transmitter in a sideways manner from the rest of the arrowhead. The sideways separation is obtained as a result of the rotating action of the blades, and the linear action of a plunger acted upon by the blades within the arrowhead. This way, the signaling tip is more likely to stay within the body of the animal, and not pass through it, to help the hunter locate the body.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: October 1, 2013
    Inventors: Thomas E. Goodwin, Gary S. Welch
  • Publication number: 20130072331
    Abstract: An expandable hunting arrowhead which ejects a signal generator and transmitter into the body of the quarry animal upon impact is described. The action of expanding blades, which rotate radially outwardly and backwardly to deploy from the sides of the arrowhead upon impact, separates the tip of the arrow containing the signal generator and transmitter in a sideways manner from the rest of the arrowhead. The sideways separation is obtained as a result of the rotating action of the blades, and the linear action of a plunger acted upon by the blades within the arrowhead. This way, the signaling tip is more likely to stay within the body of the animal, and not pass through it, to help the hunter locate the body.
    Type: Application
    Filed: March 16, 2012
    Publication date: March 21, 2013
    Inventors: THOMAS E. GOODWIN, GARY S. WELCH
  • Patent number: 5775003
    Abstract: A dry kiln for wood products that has sample tunnels mounted strategic to each of the charges (stacks) of wood products that are to be dried. A board sample is mounted in the tunnel that is representative of the charges to be dried. A sensing device mounted in the tunnel and supporting the board sample continuously monitors the weight of the board sample and inputs the information to a controller. The moisture content of the board sample at any time during the cycle is ascertained by weight. The board sample in the tunnel is subjected to the same drying conditions as the charge and therefore the moisture content of the charge will be the same as the board sample. The continuous weight monitoring of the board sample is accordingly used by the controller to control the dry cycle.
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: July 7, 1998
    Assignee: U.S. Natural Resources, Inc.
    Inventor: Thomas E. Goodwin, III
  • Patent number: 5226241
    Abstract: A weight driven kiln control system is shown and described wherein a digital scale provides sample board weight values to a kiln control system in association with sample board identification values whereby the control system may drive a load through a given drying schedule by inferring the moisture content of the load based on received weight values for a set of sample boards. The control system requires less operator expertise in manipulating the progress of the kiln through the drying schedule, and allows the kiln control system to make certain judgements about the rate of drying within the kiln and independent adjustments, if so authorized, in the drying schedule based on a calculated drying rate.
    Type: Grant
    Filed: May 18, 1992
    Date of Patent: July 13, 1993
    Assignee: U.S. Natural Resources, Inc.
    Inventor: Thomas E. Goodwin
  • Patent number: 5138773
    Abstract: A kiln for the drying of lumber utilizing panels attached to the kiln structure. The attached panels form the interior surface and the exterior surface of the kiln. The panels have a cavity for the placement of insulating material. The insulating material is encapsulated in a liquid impervious container thus preventing condensates from infiltrating the insulating material. The isolation of the insulating material from the ambient moist air of the kiln maintains the insulating quality of the insulation normally lost due to exposure to moisture laden air and also aids in preventing the corrosive effect of moist insulation in contact with the metal surfaces.
    Type: Grant
    Filed: December 5, 1990
    Date of Patent: August 18, 1992
    Assignee: U.S. Natural Resources, Inc.
    Inventors: Thomas E. Goodwin, Gary W. Hogue
  • Patent number: 4110543
    Abstract: A method of preparing hydrocarbyl-substituted cresols is disclosed. The method comprises heating a mixture of mono- or di-hydrocarbyl-substituted cresols and an alcohol, which is benzyl alcohol or a C.sub.1 -C.sub.10 aliphatic alcohol, at an elevated temperature in the presence of a catalytic amount of alumina. The product contains at least one hydrocarbyl substituent corresponding to the hydrocarbon moiety of the alcohol used in the process. A typical process employs 4,6-di-t-butyl-m-cresol and isopropanol to prepare a product mixture containing a substantial amount of thymol.
    Type: Grant
    Filed: February 24, 1977
    Date of Patent: August 29, 1978
    Assignee: Continental Oil Company
    Inventors: Thomas E. Goodwin, Charles M. Starks
  • Patent number: 4110544
    Abstract: A process for preparing cresols from di-hydrocarbyl-substituted cresols, wherein the hydrocarbyl groups contain from 3 to 7 carbon atoms, is disclosed. In the process the di-hydrocarbyl-substituted cresol is contacted with a catalyst (e.g. alumina) in the liquid phase at elevated temperatures and pressure. 4,6-di-t-butyl-m-cresol is a typical feedstock.
    Type: Grant
    Filed: January 13, 1977
    Date of Patent: August 29, 1978
    Assignee: Continental Oil Company
    Inventors: Thomas E. Goodwin, Charles M. Starks
  • Patent number: 4100207
    Abstract: A method of preparing methyl-substituted phenols is disclosed. The method comprises heating a mixture of mono- or di-hydrocarbyl-substituted cresols and methanol at an elevated temperature in the presence of a catalytic amount of magnesium oxide.
    Type: Grant
    Filed: February 24, 1977
    Date of Patent: July 11, 1978
    Assignee: Continental Oil Company
    Inventors: Thomas E. Goodwin, Charles M. Starks
  • Patent number: 4085155
    Abstract: Alkyl substituted 1,3-dimethylbenzenes are prepared by reacting a mixture of acetone and 1-alkanols over a catalyst, which preferably is alumina, at elevated temperatures and pressures. Preferably, the product contains substantial amounts of penta- and hexaalkylbenzenes.
    Type: Grant
    Filed: May 2, 1977
    Date of Patent: April 18, 1978
    Assignee: Continental Oil Company
    Inventor: Thomas E. Goodwin