Patents by Inventor Thomas E. Hughes

Thomas E. Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically encoded fluorescent sensors for detecting ligand bias and intracellular signaling through cAMP pathways
    Patent number: 12140593
    Abstract: Described herein are novel fluorescent sensors for cyclic adenosine monophosphate (cAMP) that are based on single fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: November 12, 2024
    Assignee: Montana Molecular LLC
    Inventors: Thomas E. Hughes, Paul H. Tewson, Anne Marie Quinn
  • Genetically encoded fluorescent sensors for detecting ligand bias and intracellular signaling through cAMP pathways
    Patent number: 11366114
    Abstract: Described herein are novel fluorescent sensors for cyclic adenosine monophosphate (cAMP) that are based on single fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: June 21, 2022
    Assignee: Montana Molecular LLC
    Inventors: Thomas E. Hughes, Paul H. Tewson, Anne Marie Quinn
  • Methods of treating an overweight subject
    Patent number: 10406134
    Abstract: The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: September 10, 2019
    Assignees: Zafgen, Inc., Vanderbilt University
    Inventors: Thomas E. Hughes, James E. Vath, Alan D. Cherrington
  • Methods of Treating an Overweight or Obese Subject
    Publication number: 20190224156
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
    Type: Application
    Filed: August 27, 2018
    Publication date: July 25, 2019
    Inventors: Thomas E. Hughes, James E. Vath
  • METHODS OF TREATING AGE RELATED DISORDERS
    Publication number: 20190175542
    Abstract: The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor.
    Type: Application
    Filed: June 27, 2018
    Publication date: June 13, 2019
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of treating ischemic organ damage and other disorders
    Patent number: 10231946
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: March 19, 2019
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Genetically encoded fluorescent sensors for detecting intracellular signalling through diacylglycerol pathways
    Patent number: 10131960
    Abstract: Described herein are novel fluorescent sensors for Diacyl Glycerol (DAG) and phosphatidylinositol 4,5-bisphosphate (PIP2) that are based on circularly permuted fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: November 20, 2018
    Assignee: Montana Molecular LLC
    Inventors: Thomas E. Hughes, Paul H. Tewson, Anne Marie Quinn
  • Methods of treating liver diseases
    Patent number: 10064839
    Abstract: The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: September 4, 2018
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Treatment of Obesity Using Non-Daily Administration of 6-O-(4-Dimethylaminoethoxy) Cinnamoyl Fumagillol
    Publication number: 20180221328
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions using non-daily administration of, e.g., a MetAP-2 inhibitor.
    Type: Application
    Filed: September 13, 2017
    Publication date: August 9, 2018
    Inventor: Thomas E. Hughes
  • METHODS OF TREATING ISCHEMIC ORGAN DAMAGE AND OTHER DISORDERS
    Publication number: 20180085338
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Application
    Filed: November 15, 2017
    Publication date: March 29, 2018
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of Treating an Overweight or Obese Subject
    Publication number: 20180064677
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
    Type: Application
    Filed: April 20, 2017
    Publication date: March 8, 2018
    Inventors: Thomas E. Hughes, James E. Vath
  • METHODS OF TREATING AN OVERWEIGHT SUBJECT
    Publication number: 20180055811
    Abstract: The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.
    Type: Application
    Filed: April 11, 2017
    Publication date: March 1, 2018
    Applicant: Vanderbilt University
    Inventors: Thomas E. Hughes, James E. Vath, Alan D. Cherrington
  • METHODS OF TREATING AGE RELATED DISORDERS
    Publication number: 20180042886
    Abstract: The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor.
    Type: Application
    Filed: October 10, 2017
    Publication date: February 15, 2018
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of treating impaired wound healing
    Patent number: 9849106
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: December 26, 2017
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • METHODS OF TREATING RENAL DISEASE AND OTHER DISORDERS
    Publication number: 20170333383
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Application
    Filed: February 3, 2017
    Publication date: November 23, 2017
    Inventors: Thomas E. Hughes, James E. Vath
  • METHODS OF TREATING LIVER DISEASES
    Publication number: 20170326099
    Abstract: The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: December 20, 2016
    Publication date: November 16, 2017
    Inventors: Thomas E. Hughes, James E. Vath
  • METHODS OF TREATING AGE RELATED DISORDERS
    Publication number: 20170196829
    Abstract: The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor.
    Type: Application
    Filed: August 22, 2016
    Publication date: July 13, 2017
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of treating an overweight subject
    Patent number: 9649293
    Abstract: The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: May 16, 2017
    Assignees: Zafgen, Inc., Vanderbilt University
    Inventors: Thomas E. Hughes, James E. Vath, Alan D. Cherrington
  • Methods of treating renal disease and other disorders
    Patent number: 9597309
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 21, 2017
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of treating liver diseases
    Patent number: 9561209
    Abstract: The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: February 7, 2017
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath