Abstract: Systems and methods are taught for providing customers of a cloud computing service to control when updates affect the services provided to the customers. Because multiple customers share the cloud's infrastructure, each customer may have conflicting preferences for when an update and associated downtime occurs. Preventing and resolving conflicts between the preferences of multiple customers while providing them with input for scheduling a planned update may reduce the inconvenience posed by updates. Additionally, the schedule for the update may be transmitted to customers so that they can prepare for the downtime of services associated with the update.

Abstract: Compositions and methods for reducing the toxic effects of cryopreservation in living materials undergoing standard cryopreservation procedures. In embodiments of the present invention such methods including blocking or reducing the function of the Gm14005, Nrg2/Pura, Fgd2/Pim1, Opa1/Hes1, Myh9, and Hsbp1/Ywhag genes, their gene products, or their downstream effectors. In embodiments, cells, tissues, organs, or organisms are treated with Afatinib, Staurosporine, UCN-01, Quercetagetin, LY294002, Quercetin, Adenosine monophosphate, Blebbistatin, or Agalloside prior to, during, or after the cryopreservation process to reduce cryopreservation toxicity.

Abstract: This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation.

Abstract: This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation.

Abstract: This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation.

Abstract: This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation.

Abstract: A lean premixed, radial inflow, multi-annular staged nozzle for creating three independent combustion zones within a can-annular, dual-fuel gas turbine combustor is provided. The nozzle includes a pilot zone fueled by a gas pilot nozzle and center cartridge; a flame holder zone fueled by an inner main gas fuel; a main flame zone fueled by an outer main gas fuel; a main radial swirler for mixing a portion of incoming air to the nozzle with the inner main gas fuel supply and the outer main gas fuel supply; an endcover; and means for controlling the ratio of an inner main gas fuel supplied and an outer main gas fuel supplied.

Abstract: An optical spectrometer for combustion flame temperature determination includes at least two photodetectors positioned for receiving light from a combustion flame, each of the at least two photodetectors having a different, overlapping bandwidth for detecting a respective output signal in an ultraviolet emission band; and a computer for subtracting a respective output signal of a first one of the at least two photodetectors from a respective output signal of a second one of the at least two photodetectors to obtain a segment signal, and using the segment signal to determine the combustion flame temperature.

Abstract: An improved emergency or interim lighting device and associated methods for providing emergency or temporal lighting. The device satisfies the need for an electrochemical lighting system capable of providing prolonged illumination over the life of the power unit. The device benefits from the use of LEDs as the illumination source, which provide optimum lumen output with considerably less power consumption than conventional incandescent lighting devices. By providing for a unique combination of diode arrangement and parabolic reflector the directional limitations of conventional LED lighting devices are overcome and wide area illumination coverage is provided. Additionally a multi-level lighting scheme provides for a means of identifying the device during electrical power outage and providing multiple levels of lighting intensity.

Abstract: An optical spectrometer for combustion flame temperature determination includes at least two photodetectors positioned for receiving light from a combustion flame, each of the at least two photodetectors having a different, overlap ping bandwidth for detecting a respective output signal in an ultraviolet emission band; and a computer for subtracting a respective output signal of a first one of the at least two photodetectors from a respective output signal of a second one of the at least two photodetectors to obtain a segment signal, and using the segment signal to determine the combustion flame temperature.

Abstract: A pressure transmitter with a fluid isolator that includes a sensor tube and a fill tube that have “D” shaped ends that connect together in a port internal to the transmitter. The shaped ends can be brazed into the port for sealing. Fitting both the sensor tube and the fill tube in the same port provides a low cost isolator with reduced isolator liquid volume. The fluid isolator has an isolator diaphragm with a central diaphragm region overlying a central backing plate that includes a annular groove. The annular groove avoids slow response of the isolator after an overpressure condition.

Abstract: An improved emergency or interim lighting device and associated methods for providing emergency or temporal lighting. The device satisfies the need for an electrochemical lighting system capable of providing prolonged illumination over the life of the power unit. The device benefits from the use of LEDs as the illumination source, which provide optimum lumen output with considerably less power consumption than conventional incandescent lighting devices. By providing for a unique combination of diode arrangement and parabolic reflector the directional limitations of conventional LED lighting devices are overcome and wide area illumination coverage is provided. Additionally a multi-level lighting scheme provides for a means of identifying the device during electrical power outage and providing multiple levels of lighting intensity.

Abstract: The present invention generally provides a seal assembly, or seal array, having a seal body and one or more non-extrusion end rings to prevent or minimize extrusion of the seal body between either the packer assembly and the casing or between the packer assembly and the gauge ring used to energize the seal assembly. More particularly, the end ring of the present invention has discrete deformable portions, which may be integrally encapsulated within a resilient cover or which may be provided as separate end ring members. The discrete deformable portions may further be provided with a deformable hinge portion formed therebetween.

Abstract: Bulkhead 14 is conical and therefore the surface of bulkhead liners 30 has a curved or arcuate surface 68. Raised lip 70 with planar surface 72 is adjacent and surrounded in each opening 20. Fuel nozzle guide 24 may be rotated against and sealed to the surface of the liner segments.

Abstract: Fuel nozzle guide 24 is threaded to fuel nozzle guide retainer 26, entrapping bulkhead 14, bulkhead liner 30 and key washer 28. Internal tabs 74 lock within slot 76 in the threads of the fuel nozzle guide. External tabs 78 of the key washer are bent into slot 80 of the retainer 26, after the nozzle guide 24 and the retainer are threaded together.

Abstract: Cooling air flow from behind bulkhead liner segments 30 and from behind float wall panels 42 is guided as flow 50 over the hot surface of the bulkhead liner segments by fairing 44. The fairing is secured between a shell (38,40) and a float wall panel 42, and being of equal and coincident length as the panel, may be replaced with the removal of only one panel.

Abstract: Truncated pie shaped bulkhead liner sections 60 are each divided into two liner segments 62. The division occurs adjacent fuel nozzle opening 20. Upstream extending lips 71, 75 and 77 abut the bulkhead 14. Cooling air passes through cooling flow openings in the bulkhead with all the flow continuing toward the shell 38, 40 edges of the liner segments.

Abstract: A stator assembly 14 having a spline-type connection between an inner case 24 and an outer case 26 is disclosed. Various construction details are developed, which ensure that the spline-type connection permits relative radial growth between the inner case and the outer case while providing for a rigid interconnection between the cases during blade failures which transfer loads from the outer case to the inner case. In one particular embodiment, the inner case has attached thereto a plurality of spline-type spacers 54 each having an inwardly facing surface 82 which is adapted to engage an outwardly facing surface 74 on a portion of the support structure for the outer case to restrain the outer case against radially outward movement.

Abstract: Method for fabricating a laminated coil conductor for a high current coil which includes wrapping a layer of insulation around a rotatable shaped mandrel and then winding a plurality of copper sheets over the insulation as the mandrel is rotated. Solder is interposed between the copper sheets and between coolant tubes positioned on each end of each coil conductor. The assemblage is then removed from the mandrel and raised to a temperature to bond the copper sheets and coolant tubes together. The assemblage is then placed in a structural box and a plastic is injected into the box to fill any voids between the coil conductor and the box.An assembly of a plurality of coil conductors arranged in a high current coil according to the method is illustrated.

Abstract: Method for fabricating a laminated coil conductor for a high current coil which includes wrapping a layer of insulation around a rotatable shaped mandrel and then winding a plurality of copper sheets over the insulation as the mandrel is rotated. Solder is interposed between the copper sheets and between coolant tubes positioned on each end of each coil conductor. The assemblage is then removed from the mandrel and raised to a temperature to bond the copper sheets and coolant tubes together. The assemblage is then placed in a structural box and a plastic is injected into the box to fill any voids between the coil conductor and the box.