Abstract: Farnesyl derivatives, particularly farnesyl acetate, are used to reduce the level of protein farnesylation in a mammalian host. The activity of proteins which require farnesylation for function is thereby reduced. The compounds may be administered to patients to reduce the overall level of ras protein activity, either alone or in conjunction with other drugs which act as competitive inhibitors of farnesyl protein transferase.

Abstract: A cobalt carbonate slurry and method for making same is described. The method comprises steps of reacting a water-soluble cobalt (II) salt with a water-soluble carbonate in aqueous solution in an inert atmosphere to form the desired cobalt carbonate and a water-soluble salt as a by-product; filtering the resultant cobalt carbonate; washing the resultant wet filter cake and preparing an aqueous slurry of cobalt carbonate from the wet filter cake. Preferably, the slurry is made to a pumpable viscosity. Additives may be used for specific applications to retard settling. Slurries prepared from the wet filter cake are superior to those prepared from the dry powder form because they are more uniform and stable for longer periods of time and resuspend more readily.