Abstract: An arterial air capture chamber (101) is used in dialysis. The arterial air capture chamber (101) includes an upwardly extending fluid inlet (102) terminating in a fluid inlet port (105) positioned at about a 90° turn relative to a fluid flow of a fluid inlet tube (107). The arterial air capture chamber (101) includes a draw tube (104) with an opposedly positioned beveled opening (306) at about 180° relative to the fluid inlet port (105). The arterial air capture chamber (101) provides improved fluid dynamics, reducing both stagnant flow and turbulence. The arterial air capture chamber (101) also provides for bidirectional flow of fluid through the arterial air capture chamber (101).

Abstract: The invention relates to devices, systems, and methods for calculating a bicarbonate concentration in a fluid used in dialysis. The devices, systems, and methods can be used to calculate the bicarbonate concentration in either dialysate or blood. The invention measures the amount of carbon dioxide in both an acidified and non-acidified solution and calculates the bicarbonate concentration based on the difference in carbon dioxide concentrations.

Abstract: The invention relates to devices, systems, and methods for generating a peritoneal dialysate having specified concentrations of one or more solutes. The devices, systems and methods use conductivity sensors, flow meters, and composition sensors to control addition of osmotic agents and ion concentrates into a peritoneal dialysate generation flow path.

Abstract: Systems and methods for managing the pH of a dialysate fluid during hemodialysis therapy. The systems and methods adjust dialysate pH and buffer concentration to generate a predetermined total bicarbonate buffer concentration in a dialysate entering a dialyzer.

Abstract: An apparatus includes a body, a flexible cannula, and a needle. The needle is resiliently biased to extend along at least one proximal curve through least one proximal curved needle portion. The needle is resiliently biased to extend along at least one distal curve through at least one distal curved needle portion. In another embodiment, an apparatus includes a main body portion including a proximal channel configured to receive a plunger of a syringe, and a stop surface configured to selectively engage the plunger of the syringe to arrest distal advancement of the plunger. The apparatus also includes first and second deflectable beams configured to cooperate with each other to securely grip the barrel of the syringe, and first and second deflectable flanges configured to cooperate with each other to grip the barrel of the syringe.

Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.

Abstract: Systems and methods for managing the pH of a dialysate fluid during hemodialysis therapy. The systems and methods adjust dialysate pH and buffer concentration to generate a predetermined total bicarbonate buffer concentration in a dialysate entering a dialyzer. The systems and methods generate a pH-modifying fluid and selectively add the pH modifying fluid to the dialysate in order to accurately control the total bicarbonate buffer concentration in the dialysate entering the dialyzer.

Abstract: The invention relates to devices, systems, and methods for calculating a bicarbonate concentration in a fluid used in dialysis. The devices, systems, and methods can be used to calculate the bicarbonate concentration in either dialysate or blood. The invention measures the amount of carbon dioxide in both an acidified and non-acidified solution and calculates the bicarbonate concentration based on the difference in carbon dioxide concentrations.

Abstract: The invention relates to systems and methods for generation and use of peritoneal dialysis fluid. The peritoneal dialysis fluid is generated by dissolving solids or diluting concentrated liquids in a single container having all components of the final peritoneal dialysis fluid.

Abstract: A system for measuring at least one fluid characteristic at various stages within a sorbent system that has a sorbent cartridge that has at least one material layer and at least one fluid passageway in at least one location in the sorbent system to provide a diverted sample stream from the various stages. At least one fluid characteristic of the diverted sample stream is measured.

Abstract: An apparatus includes a body, a flexible cannula, and a needle. The cannula is sized and configured to advance between a sclera and a choroid of a patient's eye. The needle is slidably disposed in the cannula and includes a sharp distal tip. The needle translates relative to the cannula between a proximal position and a distal position. The distal tip is positioned inside the cannula when the needle is in the proximal position. The distal tip is positioned outside the cannula when the needle is in the distal position. The needle is resiliently biased to extend along at least one proximal curve through least one proximal curved needle portion. The needle is resiliently biased to extend along at least one distal curve through at least one distal curved needle portion. The at least one distal curve is different from the at least one proximal curve.

Abstract: An apparatus includes a body, and anchoring feature, and a guide feature. The body is sized and configured to be positioned on an eye of a patient. The anchoring feature is configured to secure the body to the eye of the patient. The guide feature is configured to guide a cannula into a scleral incision formed in the eye of the patient along a path that is substantially tangential relative to the eye of the patient. The guide feature is sized and configured to allow the cannula to pivot laterally through a range of angular motion at the scleral incision.

Abstract: Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.

Abstract: Systems and methods of generating and regenerating peritoneal dialysate are provided. The systems and methods use a dialysate regeneration module, a sterilization module and concentrates to prepare peritoneal dialysate from used peritoneal dialysate or source water. An optional integrated cycler for direct infusion of the generated peritoneal dialysate is included. Optional dialysate storage containers are provided for storage of the peritoneal dialysate prior to use.

Abstract: An apparatus includes a body and an outer cannula extending distally from the body along a longitudinal axis and fixedly secured to the body. The outer cannula includes a proximal portion having a first cross-dimension and a distal portion having a second cross-dimension smaller than the first cross-dimension. The distal portion is configured to guide the cylindrical proximal portion into a trocar port. The apparatus also includes an inner cannula slidably disposed in the outer cannula for translating longitudinally relative to the outer cannula. The inner cannula includes an open proximal end, an open distal end configured to pierce a retina of the eye, and a lumen extending between the open proximal end and the open distal end. The lumen is configured to communicate a fluid from the open proximal end to the open distal end for delivering the fluid into a subretinal region of the eye.

Abstract: Devices, systems, and methods for high capacity degassing of dissolved gases and gas bubbles from fluid such as a dialysate are provided. The devices, systems, and methods can include a degassing vessel with at least two degassing chambers. The fluid can be degassed in a first degassing chamber and recirculated through a second recirculating degassing chamber to remove a desired amount of gas such as carbon dioxide.

Abstract: An apparatus includes a body, and anchoring feature, and a guide feature. The body is sized and configured to be positioned on an eye of a patient. The anchoring feature is configured to secure the body to the eye of the patient. The guide feature is configured to guide a cannula into a scleral incision formed in the eye of the patient along a path that is substantially tangential relative to the eye of the patient. The guide feature is sized and configured to allow the cannula to pivot laterally through a range of angular motion at the scleral incision.

Abstract: An apparatus includes a body and a pair of rigid legs extending from the body. The body includes an engagement feature configured to engage a deployment instrument. The legs are parallel with each other. Each leg has a sharp tip. The legs both extend along a plane. The body defines a guide opening. The guide opening is oriented transversely relative to the plane associated with the legs. The guide opening is sized to receive a cannula having a generally flat profile. The guide opening is configured to guide the cannula through a sclerotomy at a substantially tangential orientation.

Abstract: A portable dialysis cabinet for use in dialysis. The portable dialysis cabinet can have a size and weight that facilitates easy movement of the cabinet from one location to another with relative ease. The portable dialysis cabinet can have additional features necessary to facilitate portability, such as wheels and a handle. In general, the portable dialysis cabinet can contain all the necessary components for performing a dialysis session.

Abstract: An apparatus includes a body and a pair of rigid legs extending from the body. The body includes an engagement feature configured to engage a deployment instrument. The legs are parallel with each other. Each leg has a sharp tip. The legs both extend along a plane. The body defines a guide opening. The guide opening is oriented transversely relative to the plane associated with the legs. The guide opening is sized to receive a cannula having a generally flat profile. The guide opening is configured to guide the cannula through a sclerotomy at a substantially tangential orientation.