Abstract: Apparatus, systems and methods for ultrasound and photoacoustic guidance of coronary procedures are disclosed herein. Certain embodiments include a first catheter comprising an ultrasound transceiver, and a second catheter comprising a proximal end and a distal end, with a photoacoustic excitation light transmitter positioned at the distal end of the second catheter. The photoacoustic excitation light transmitter can be configured to emit excitation light in a conical pattern and at a specific pulse duration. The second catheter can be configured to detect photoacoustic signals resulting from the absorption of excitation light emitted by the photoacoustic excitation light transmitter.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to identify endometrial tissue.

Abstract: Exemplary embodiments of the present disclosure include systems and methods for treatment of occlusions, including coronary artery chronic total occlusions.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to classify the plaque tissue present in the coronary artery using intravascular optical coherence tomography (IVOCT) images.

Abstract: Apparatus and methods for tissue excision. In certain aspects, the apparatus and methods include an annular converging laser beam. The annular converging laser beam can be directed to a surface of a tissue and displace a portion of the tissue in a single or multiple laser pulses. In particular aspects, the dosimetry of the laser beam (e.g. the beam shape, pulse energy and pulse duration) can be controlled to eject the portion of the tissue in a manner to reduce damage to the displaced tissue and the surrounding tissue.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to classify the plaque tissue present in the coronary artery using intravascular optical coherence tomography (IVOCT) images.

Abstract: The present disclosure includes catheter systems and methods for treatment of occlusions, including coronary artery chronic total occlusions. The catheter system comprises a catheter coupled to a control system with a distal end inserted into a patient and proximal to a location within a blood vessel with an occlusion. The catheter comprises a flexible outer sheath surrounding a housing with a plurality of lumens to perform various functions to penetrate occlusions.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to identify endometrial tissue.

Abstract: Exemplary embodiments of the present disclosure apparatus and methods that provide for subtractive material processing, including efficient and precise ablation of tissues. Certain embodiments include a first laser configured to direct a first pulse of energy at a first wavelength to a region of tissue; a second laser configured to direct a second pulse of energy at a second wavelength to the region of tissue; and a control system configured to control operation of the first laser and the second laser.

Abstract: Apparatus, systems and methods for fracturing calcium in an artery of a patient. Certain embodiments include an expandable member, a laser light source and an optical fiber coupled to the laser light source. The optical fiber can comprise one or more emission points configured to emit electromagnetic energy from the laser light source. The electromagnetic energy can be transmitted through a fluid in the expandable member to fracture the calcium.

Abstract: The invention relates to an apparatus for in vivo imaging. More specifically, the present invention relates to a catheter that incorporates an Optical Coherence Tomography (OCT) system and an Intravascular Ultrasound (“IVUS) system for concurrent imaging of luminal systems, such as imaging the vasculature system, including, without limitation, cardiac vasculature, peripheral vasculature and neural vasculature.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to identify endometrial tissue.

Abstract: Exemplary embodiments of the present disclosure include systems and methods capable of imaging, manipulating, and analyzing tissue using light, including for example, coagulating and breaking the molecular bonds (e.g. cutting) tissue.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to identify endometrial tissue.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to identify endometrial tissue.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to classify the plaque tissue present in the coronary artery using intravascular optical coherence tomography (IVOCT) images.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to identify endometrial tissue.

Abstract: In some embodiments, a system for scoring human endocardium tissue may include a first conduit and an activation system. The first conduit may include a first opening, a second opening, and a cutting device. The first opening may be positioned at a proximal end of the first conduit. The second opening may extend from adjacent to a closed distal end portion of the first conduit. The cutting device, when activated, may cut through a portion of a depth of endocardium tissue positioned adjacent the second opening. The cutting device may selectively cut or score the endocardium to a specified depth and length in the endocardium of a left ventricle of a human heart.

Abstract: In some embodiments, a method of ameliorating diastolic dysfunction may include positioning at least a distal end of a system for cutting a trabeculae carneae in a left ventricle of a human heart. The system may include an elongated member, a grip, an engaging portion, and a cutting device. A second end of the engaging portion may turn in upon the engaging portion towards a first end of the engaging portion while still allowing trabeculae carneae to enter through an opening between the first and second ends. The cutting device may be positioned within an inner diameter of the engaging portion. The method may include positioning at least one trabeculae carneae in the inner diameter of the engaging portion. The method may include severing the at least one trabeculae carneae. The method may include increasing left ventricular compliance of the human heart.

Abstract: The invention relates to an apparatus for in vivo imaging. More specifically, the present invention relates to a catheter that incorporates an Optical Coherence Tomography (OCT) system and an Intravascular Ultrasound (“IVUS) system for concurrent imaging of luminal systems, such as imaging the vasculature system, including, without limitation, cardiac vasculature, peripheral vasculature and neural vasculature.