Patents by Inventor Thomas E. Rohr

Thomas E. Rohr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6294342
    Abstract: Assay methods utilizing the response of a magnetically responsive reagent to the influence of a magnetic field to qualitatively or quantitatively measure binding between specific binding pair members. According to the invention, the presence of an analyte mediates whether or not the magnetically responsive reagent binds to a mobile solid phase reagent. The extent of binding will modulate the response of the magnetically responsive reagent or that of the mobile solid phase reagent, or both, to the influence of a magnetic field. Hence, by measuring the response to the magnetic field of the magnetically responsive reagent, or that of the mobile solid phase reagent, the presence or amount of analyte contained in a test sample can accurately be determined. The invention utilizes various devices to carry out the assay methods described.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: September 25, 2001
    Assignee: Abbott Laboratories
    Inventors: Thomas E. Rohr, Tuan A. Elstrom, Lawrence V. Howard, Eric B. Shain
  • Patent number: 5998224
    Abstract: Assay methods utilizing the response of a magnetically responsive reagent to the influence of a magnetic field to qualitatively or quantitatively measure binding between specific binding pair members. According to the invention, the presence of an analyte mediates whether or not the magnetically responsive reagent binds to a mobile solid phase reagent. The extent of binding will modulate the response of the magnetically responsive reagent or that of the mobile solid phase reagent, or both, to the influence of a magnetic field. Hence, by measuring the response to the magnetic field of the magnetically responsive reagent, or that of the mobile solid phase reagent, the presence or amount of analyte contained in a test sample can accurately be determined. The invention utilizes various devices to carry out the assay methods described.
    Type: Grant
    Filed: May 16, 1997
    Date of Patent: December 7, 1999
    Assignee: Abbott Laboratories
    Inventors: Thomas E. Rohr, Tuan A. Elstrom, Lawrence V. Howard, Eric B. Shain
  • Patent number: 5567628
    Abstract: A method, composition, device, apparatus, and kit for the determination of the presence or amount of an analyte by monitoring an analyte-mediated ligand binding event in a test mixture which contains the analyte to be assayed, a specific binding member, a Raman-active label, and a particulate having a surface capable of inducing a surface-enhanced Raman light scattering. The test mixture is illuminated with a radiation sufficient to cause the Raman-active label in the test mixture to emit a detectable Raman spectrum. The differences in the detected surface-enhanced Raman scattering spectra are dependent upon the amount of the analyte present in the test mixture. Thus, by monitoring these differences, the presence or amount of the analyte are determined.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: October 22, 1996
    Assignee: Abbott Laboratories
    Inventors: Peter J. Tarcha, Thomas E. Rohr, James J. Markese, Therese Cotton, Bernard N. Rospendowski
  • Patent number: 5445970
    Abstract: The present invention provides assay methods for performing binding assays, wherein the detectable label is a magnetically responsive material. Direct and indirect, competitive and sandwich assay formats are used to partition the magnetically attractable label between a solid phase and a fluid phase in proportion to the presence or amount of analyte in the test sample. The magnetic responsiveness of the magnetically attractable label in one or both phases results in the exertion of a force upon the label. By determining the extent of the force or influence of the force exerted upon the label, the amount of the analyte in the test sample is determined.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: August 29, 1995
    Assignee: Abbott Laboratories
    Inventor: Thomas E. Rohr
  • Patent number: 5445972
    Abstract: A Raman label which, upon radiation, produces a detectable Raman scattering signal in a ligand-binding assay for an analyte in a test sample. A conjugate containing a Raman label attached to a specific binding member.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: August 29, 1995
    Assignee: Abbott Laboratories
    Inventors: Peter J. Tarcha, Thomas E. Rohr, Therese Cotton, Gary E. Winter
  • Patent number: 5445971
    Abstract: The present invention provides devices for performing binding assays. Such devices comprise (i) a reaction vessel where unbound and immobilized magnetically-labeled reagent are produced in relation to the amount of said analyte in said test sample; (ii) a separation means for partitioning said immobilized magnetically-labeled reagent and said bound magnetically-labeled reagent; (iii) a magnetic field generator means for the application of a magnetic field to said magnetically-labeled reagent; and (iv) a measurement means to assess the effect of said magnetic field on said magnetically-labeled reagent as a measure of the presence or amount of said analyte in said test sample. The device provided by the instant invention can run, for example, direct indirect, competitive, inhibition and sandwich assay formats.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: August 29, 1995
    Assignee: Abbott Laboratories
    Inventor: Thomas E. Rohr
  • Patent number: 5376556
    Abstract: A method, composition, device, apparatus, and kit for the determination of the presence or amount of an analyte by monitoring an analyte-mediated ligand binding event in a test mixture which contains the analyte to be assayed, a specific binding member, a Raman-active label, and a particulate having a surface capable of inducing a surface-enhanced Raman light scattering. The test mixture is illuminated with a radiation sufficient to cause the Raman-active label in the test mixture to emit a detectable Raman spectrum. The differences in the detected surface-enhanced Raman scattering spectra are dependent upon the amount of the analyte present in the test mixture. Thus, by monitoring these differences, the presence or amount of the analyte are determined.
    Type: Grant
    Filed: September 11, 1992
    Date of Patent: December 27, 1994
    Assignee: Abbott Laboratories
    Inventors: Peter J. Tarcha, Thomas E. Rohr, James J. Markese, Therese Cotton, Bernard N. Rospendowski
  • Patent number: 5266498
    Abstract: An assay for an analyte in a test sample that uses a ligand binding reaction between the analyte and a specific binding member or a binding member pair that includes one binding member having a Raman active reporter. The analyte can be assayed by measurement of the Raman scattering signal of the Raman-active reporter. The Raman scattering signal can be either a noon-enhanced Raman scattering signal or a Raman scattering signal that is enhanced by a surface capable of enhancing that Raman scattering signal.
    Type: Grant
    Filed: November 7, 1991
    Date of Patent: November 30, 1993
    Assignee: Abbott Laboratories
    Inventors: Peter J. Tarcha, Thomas E. Rohr, Therese Cotton