Patents by Inventor Thomas E. Smyser

Thomas E. Smyser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREPARATION OF AMINOTETRALIN COMPOUNDS
    Publication number: 20150112071
    Abstract: The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention.
    Type: Application
    Filed: May 29, 2014
    Publication date: April 23, 2015
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Alexandra E. Gould, Sean J. Harrison, Hirotake Mizutani, Ming Shen, Thomas E. Smyser, Stephen G. Stroud
  • PREPARATION OF AMINOTETRALIN COMPOUNDS
    Publication number: 20140256947
    Abstract: The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention.
    Type: Application
    Filed: October 10, 2013
    Publication date: September 11, 2014
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Alexandra E. Gould, Sean J. Harrison, Hirotake Mizutani, Ming Shen, Thomas E. Smyser, Stephen G. Stroud
  • PREPARATION OF AMINOTETRALIN COMPOUNDS
    Publication number: 20100197924
    Abstract: The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention.
    Type: Application
    Filed: December 16, 2009
    Publication date: August 5, 2010
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Alexandra E. Gould, Sean J. Harrison, Hirotake Mizutani, Ming Shen, Thomas E. Smyser, Stephen G. Stroud
  • Efficient process for the preparation of a factor Xa inhibitor
    Publication number: 20040198787
    Abstract: The present invention relates to the process for the preparation of the compound of Formula I: 1
    Type: Application
    Filed: April 15, 2004
    Publication date: October 7, 2004
    Inventors: Hui-Yin Li, Luigi Anzalone, Fuqiang Jin, David J. Meloni, Jung-Hui Sun, Lucius T. Rossano, Christopher A. Teleha, Jiacheng Zhou, Thomas E. Smyser
  • Efficient process for the preparation of a factor Xa inhibitor
    Patent number: 6747158
    Abstract: The present invention relates to the process for the preparation of the compound of Formula I: from its corresponding 3-cyano-4-fluorophenyl-pyrazole and intermediates useful therein.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: June 8, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Hui-Yin Li, Luigi Anzalone, Fuqiang Jin, David J. Meloni, Jung-Hui Sun, Lucius T. Rossano, Christopher A. Teleha, Jiacheng Zhou, Thomas E. Smyser
  • Efficient process for the preparation of a factor Xa inhibitor
    Patent number: 6667332
    Abstract: The present invention relates to the process for the preparation of the compound of Formula I: from its corresponding 3-cyano-4-fluorophenyl-pyrazole and intermediates useful therein.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: December 23, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Hui-Yin Li, Luigi Anzalone, Fuqiang Jin, David J. Meloni, Jung-Hui Sun, Christopher A. Teleha, Jia C. Zhou, Thomas E. Smyser
  • Efficient process for the preparation of a factor Xa inhibitor
    Publication number: 20030212117
    Abstract: The present invention relates to the process for the preparation of the compound of Formula I: 1
    Type: Application
    Filed: May 7, 2003
    Publication date: November 13, 2003
    Inventors: Hui-Yin Li, Luigi Anzalone, Fuqiang Jin, David J. Meloni, Jung-Hui Sun, Lucius T. Rossano, Christopher A. Teleha, Jiacheng Zhou, Thomas E. Smyser
  • Efficient process for the preparation of a factor Xa inhibitor
    Publication number: 20020061917
    Abstract: The present invention relates to the process for the preparation of the compound of Formula I: 1
    Type: Application
    Filed: September 21, 2001
    Publication date: May 23, 2002
    Inventors: Hui-Yin Li, Luigi Anzalone, Fuqiang Jin, David J. Meloni, Jung-Hui Sun, Christopher A. Teleha, Jia C. Zhou, Thomas E. Smyser
  • Preparation of asymmetric cyclic ureas using an alkali metal in liquid ammonia process
    Patent number: 5998614
    Abstract: The present invention describes a method for the preparation of asymmetric N,N'-disubstituted cyclic ureas through the selective monodebenzylation of symmetric N,N'-disubstituted cyclic ureas using a dissolving metal reduction. The intermediates can be alkylated to give compounds which are useful as HIV protease inhibitors for the treatment of HIV infection.
    Type: Grant
    Filed: July 6, 1998
    Date of Patent: December 7, 1999
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Thomas E Smyser, Pasquale N. Confalone
  • Method for preparing N,N'-disubstituted cyclic ureas
    Patent number: 5532356
    Abstract: The present invention relates to methods for the preparation of disubstituted cyclic ureas of the formula (IV): ##STR1## from linear diaminodiols. These cyclic urea compounds are useful as HIV protease inhibitor compounds for the treatment of HIV infection.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 2, 1996
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Thomas E. Smyser, Pasquale N. Confalone