Patents by Inventor Thomas E. Wagner

Thomas E. Wagner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200368172
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Application
    Filed: June 5, 2020
    Publication date: November 26, 2020
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Patent number: 10801041
    Abstract: The present invention relates generally to a gene expression system utilizing an alphavirus replicon and T7 promoter. The system is capable of expressing proteins in the cell cytoplasm without integrating the gene of interest into the genome of a host cell. The invention has a wide range of applications such as producing induced pluripotent cells and vaccines against pathogens and cancers.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: October 13, 2020
    Assignee: Orbis Health Solutions, LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20200297829
    Abstract: Disclosed are means, methods, and compositions of matter useful for treatment of cancer through integrated immunotherapy. In one embodiment a synergistic protocol is comprised of: a) establishing a proteomic, genomic, and immunological profile of the patient; b) stimulation of a change in the tumor microenvironment in order to modify the tumor microenvironment to be more conducive to immunotherapy; c) priming the immune system in order to be prepared for immune activation; d) activate vaccination in order to induce antigen specific immune responses; e) induction of damage to the tumor in an immunogenic manner; f) immune focusing by utilization of epitope specific vaccination; and g) boosting the immune response.
    Type: Application
    Filed: March 18, 2019
    Publication date: September 24, 2020
    Inventors: Samuel C. Wagner, Thomas E. Ichim
  • Patent number: 10746265
    Abstract: An adjustable bracket for alternator and related products, including an alternator that adjustably secures with the timing gear cover found on most vehicle engines, an offset mounting bracket securing with the gear cover, and having upwardly extending inclined arms, for connecting with the bottom of the alternator, and a tensioning arm also securing with the timing cover, having an integral bend upwardly towards its linear and arcuate portion, with the arcuate portions of the tensioning arm having a slot formed therein, through which an adjustment bolt secures with the upper part of the alternator, to allow for the alternator to be pivoted, about its offset mounting bracket, to apply the proper tensioning to its installed V belt, to attain its proper operations.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: August 18, 2020
    Assignee: Wagner Products Company
    Inventor: Thomas E Wagner
  • Patent number: 10675249
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 9, 2020
    Assignee: Orbis Health Solutions, LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20200139895
    Abstract: A trailer hitch mounted recycling, transporting, and even a waste container transporting apparatus includes a tubing connector, that secures with the trailer hitch of a vehicle, and having a support plate, that mounts a lifting tube permanently thereon. A pivot rod pivotally secures to the upper end of the lifting tube, and the pivot rod connects with a lifting lever, which when pivoted from a vertical to a horizontal position, allows for movement of a container either onto or off of the ground, in preparation for its transport, or removal from this apparatus. A lifting hook slidably engages with the lifting tube, and connects with a lifting bracket at its upper end, which connects with a short lever, that provides a sliding movement to the lifting hook either upwardly with respect to the lifting tube, or downwardly therefrom, so that its hook device can secure to the container to provide for its lifting, transport, and lowering, after it has been moved to a distant location.
    Type: Application
    Filed: November 1, 2019
    Publication date: May 7, 2020
    Inventor: Thomas E. Wagner
  • Publication number: 20200069596
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Application
    Filed: November 6, 2019
    Publication date: March 5, 2020
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Patent number: 10500219
    Abstract: Methods and compositions using an orthosilicate for tissue regeneration, such as to treat a disease or condition, are described, including on the skin. Also described are methods for making such compositions.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: December 10, 2019
    Assignee: Orbis Health Solutions LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20190365657
    Abstract: The disclosed bead vectors direct entry into a cell of monocytic origin and cause the expression of an extracellular domain of PD-1, an anti-CTLA4 antibody, or an antibody that is specific for a checkpoint protein. The bead vectors can comprise a nucleic acid component, a lysosome evading component and a bead particle that can be phagocytized. The disclosed vectors are useful in various methods of cancer therapy, treatment, and prevention. Due to the ability of monocytic cells to target tumors, the disclosed vectors are particularly well suited for use in anti-tumor applications and directing expression of target genes in tumor-associated macrophages.
    Type: Application
    Filed: August 17, 2017
    Publication date: December 5, 2019
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20190282641
    Abstract: Disclosed are means, methods, and compositions of matter useful for generation of viruses that selectively grow in the tumor endothelium and causes lysis or augmentation of tumor immunity. In one embodiment an oncolytic virus is selectively maintained in cells resembling tumor endothelium under conditions allowing for the oncolytic virus to capture immunogenic entities found on the cells resembling tumor endothelial cells. In another embodiment, the endothelial cells resembling tumor endothelial cells are utilized as a “Trojan horse” for selective delivery of virus into a tumor or tumor microenvironment.
    Type: Application
    Filed: March 18, 2019
    Publication date: September 19, 2019
    Inventors: Samuel C. Wagner, Thomas E. Ichim
  • Publication number: 20190262201
    Abstract: A patient support apparatus may include a support surface configured to conduct air along a top face of the support surface so that heat and moisture from a patient lying on the support surface are drawn away from the top face of the support surface. An opening may be formed in a side of the support surface. A cavity may extend from the opening into the support surface. An inlet port may be positioned within the cavity and fluidly coupled to the top face. A blower assembly may be configured to position within the cavity. The blower assembly may have an outlet port that couples to the inlet port when the blower assembly is positioned within the cavity. The blower assembly may conduct air through the inlet port to the top face of the support surface.
    Type: Application
    Filed: February 26, 2019
    Publication date: August 29, 2019
    Inventors: Darrell L. Borgman, Douglas E. Borgman, Arpit Shah, Wui Hsien Wong, Keith Moores, Jason M. Gilreath, Michael R. Montini, Charles A. Lachenbruch, Eric R. Meyer, Frank E. Sauser, Catherine M. Wagner, Rachel L. Williamson, Brandon P. Fisk, Jason B. Grace, Brian Guthrie, Nicole Johannigman, Gregory J. Shannon, David C. Newkirk, Michael Churilla, Jnanesha Ramegowda, Taylor Franklin, Kathryn R. Smith, John G. Byers, Frederick K. Schultz, Andrew R. Wager, Sridhar Karimpuzha Seshadri, Gary R. Gibbons, Scott M. Corbin, John Goewert, Thomas L. Simpson, Faron L. Blessing, James D. Voll, Kin Meng Choi, Stephen S. Amrhein, Herve Gautier, Jean-Francois Lellig, Philippe Kaikenger, Matthieu Guetta
  • Publication number: 20190255127
    Abstract: Disclosed are means of treatment of cancer by enhancing efficacy of oncolytic virus ability to eradicate tumors through the destruction/inactivation of cancer endothelial cells through immunological means. In one embodiment of the invention, administration of placental endothelial cells generated antitumor endothelial immune responses are used to sensitize tumors to oncolytic viral entry. In another embodiment, oncolytic viruses are utilized to enhance generation of cancer endothelial specific responses by causing localized inflammation in the tumor endothelium, which enhances efficacy of the tumor endothelial targeting vaccine. In another embodiment, the invention teaches the use of replication deficient oncolytic viruses to deliver proteins to tumor cells in an immunogenic manner such that proteins encoded by the oncolytic viruses induce immunity to tumor endothelial cell antigens.
    Type: Application
    Filed: February 21, 2019
    Publication date: August 22, 2019
    Inventors: Samuel C. Wagner, Thomas E. Ichim
  • Publication number: 20190239937
    Abstract: Disclosed are means, methods, and compositions, useful for augmenting immune response to tumor cell death occurring in the body, wherein the tumor cell death acts as a source of antigens to stimulate an anti-cancer immune response. In one embodiment of the invention cryosurgery is performed in a manner to facilitate immune mediated killing of distant tumors, in effect causing an abscopal reaction, the amplification of the abscopal reaction is performed by preimmunization with antigen compositions generated to target tumor endothelium. In another embodiment the invention teaches the amplification of abscopal effect by preimmunizing with placental and/or tumor antigens prior to induction of necrotic cell death through means such as cryoablation, hyperthermia, radiation therapy, radiation therapy and intravenous vitamin C, and chemotherapy.
    Type: Application
    Filed: February 4, 2019
    Publication date: August 8, 2019
    Inventors: Samuel C. Wagner, Thomas E. Ichim
  • Publication number: 20190240162
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Application
    Filed: December 20, 2018
    Publication date: August 8, 2019
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20190224292
    Abstract: Disclosed are means, methods, and compositions of matter useful for augmentation of a vaccine induced antitumor immune response through immunological targeting of tumor endothelium. In one embodiment a cancer antigen specific vaccine is combined with an endothelial targeting vaccine in a manner to facilitate release of tumor antigens as a result of endothelial destruction. The released tumor antigens serve to amplify immune response induced by the cancer antigen specific vaccine. In one embodiment an endogenous cancer vaccine is utilized as a source of immunization. The endogenous cancer vaccine may be cancer cells induced to die locally such as by means of: hyperthermia, irradiation, oncolytic virus exposure, and embolization.
    Type: Application
    Filed: January 17, 2019
    Publication date: July 25, 2019
    Inventors: Samuel C. Wagner, Thomas E. Ichim
  • Publication number: 20190201511
    Abstract: Disclosed are methods of preventing pregnancy through induction of immunological responses through vaccination with placental extracts and products associated with placentation. In one particular embodiment an immune response is triggered towards pregnancy associated neoangiogenesis through administration of placental endothelial cells capable of triggering immunity. In other embodiments the process of replicating immunological events associated with pregnancy failure are recapitulated by stimulation of immunity to antigens such as VEGFR-1, VEGFR-2, CD105, FGF1-R, Integrin ?v?3, and CD-248.
    Type: Application
    Filed: January 3, 2019
    Publication date: July 4, 2019
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Santosh Kesari
  • Publication number: 20190161798
    Abstract: Disclosed are methods of selecting donors for production of anti-angiogenic vaccines in order to ensure maximal elicitation of immunity. In one embodiment, the invention teaches the purposeful mismatching of major and/or minor human leukocyte antigen (HLA) between the donor and recipient. In other embodiments the invention provides a system for generating a cell bank, said cell bank comprising different donor originals that are subsequently matched with recipients for optimal immune response. In another embodiment cells are transfected to induce immunogenicity, in some embodiments, transfected with allogeneic and/or syngeneic antigens.
    Type: Application
    Filed: November 30, 2018
    Publication date: May 30, 2019
    Inventors: Samuel C. Wagner, Thomas E. Ichim
  • Patent number: 10188680
    Abstract: Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: January 29, 2019
    Assignee: Orbis Health Solutions LLC
    Inventor: Thomas E. Wagner
  • Patent number: 10188672
    Abstract: Methods and compositions using an orthosilicate for tissue regeneration, such as to treat a disease or condition, are described, including on the skin. Also described are methods for making such compositions.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: January 29, 2019
    Assignee: Orbis Health Solutions LLC
    Inventor: Thomas E. Wagner
  • Patent number: 10166195
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: January 1, 2019
    Assignee: Orbis Health Solutions, LLC
    Inventor: Thomas E. Wagner