Abstract: The current invention provides monocytic cells transfected with chimeric antigen receptor (CAR) to selectively home to tumors and upon homing differentiate into dendritic cells capable of activating immunity which is inhibitory to said tumor. In one embodiment of the invention, monocytic cells are transfected with a construct encoding an antigen binding domain, a transcellular or structural domain, and an intracellular signaling domain. In one specific aspect of the invention, the antigen binding domain interacts with sufficient affinity to a tumor antigen, capable of triggering said intracellular domain to induce an activation signal to induce monocyte differentiation into DC.

Abstract: The current invention provides monocytic cells transfected with chimeric antigen receptor (CAR) to selectively home to tumors and upon homing differentiate into dendritic cells capable of activating immunity which is inhibitory to said tumor. In one embodiment of the invention, monocytic cells are transfected with a construct encoding an antigen binding domain, a transcellular or structural domain, and an intracellular signaling domain. In one specific aspect of the invention, the antigen binding domain interacts with sufficient affinity to a tumor antigen, capable of triggering said intracellular domain to induce an activation signal to induce monocyte differentiation into DC.

Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.

Abstract: The present invention generally relates to compositions and methods for delivering a vaccine.

Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.

Abstract: The present disclosure provides particles for delivering a nucleic acid that encodes an immunogenic peptide in an antigen presenting cell. The disclosed particles can function as a vaccine and can be used to treat or prevent a viral or bacterial infection in a subject by expressing in vivo an immunogenic peptide, thereby stimulating the subject's immune system to attack the virus or bacteria that naturally express the immunogenic peptide.

Abstract: The present disclosure provides delivery vectors for expressing a chimeric receptor in a monocytic cell, such as a macrophage or dendritic cell. The chimeric receptor may specifically bind to a particular antigen or target molecule, such as an immune checkpoint protein or OX40. The disclosed delivery vectors can be used to treat cancer in a subject by expressing in vivo a chimeric receptor on the surface of the subject's monocytic cells.

Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.

Abstract: The present disclosure provides particles for delivering a nucleic acid that encodes an immunogenic peptide in an antigen presenting cell. The disclosed particles can function as a vaccine and can be used to treat or prevent a viral or bacterial infection in a subject by expressing in vivo an immunogenic peptide, thereby stimulating the subject's immune system to attack the virus or bacteria that naturally express the immunogenic peptide.

Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.

Abstract: Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.

Abstract: A trailer hitch mounted recycling, transporting, and even a waste container transporting apparatus includes a tubing connector, that secures with the trailer hitch of a vehicle, and having a support plate, that mounts a lifting tube permanently thereon. A pivot rod pivotally secures to the upper end of the lifting tube, and the pivot rod connects with a lifting lever, which when pivoted from a vertical to a horizontal position, allows for movement of a container either onto or off of the ground, in preparation for its transport, or removal from this apparatus. A lifting hook slidably engages with the lifting tube, and connects with a lifting bracket at its upper end, which connects with a short lever, that provides a sliding movement to the lifting hook either upwardly with respect to the lifting tube, or downwardly therefrom, so that its hook device can secure to the container to provide for its lifting, transport, and lowering, after it has been moved to a distant location.

Abstract: Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.

Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.

Abstract: The present invention relates generally to a gene expression system utilizing an alphavirus replicon and T7 promoter. The system is capable of expressing proteins in the cell cytoplasm without integrating the gene of interest into the genome of a host cell. The invention has a wide range of applications such as producing induced pluripotent cells and vaccines against pathogens and cancers.

Abstract: An adjustable bracket for alternator and related products, including an alternator that adjustably secures with the timing gear cover found on most vehicle engines, an offset mounting bracket securing with the gear cover, and having upwardly extending inclined arms, for connecting with the bottom of the alternator, and a tensioning arm also securing with the timing cover, having an integral bend upwardly towards its linear and arcuate portion, with the arcuate portions of the tensioning arm having a slot formed therein, through which an adjustment bolt secures with the upper part of the alternator, to allow for the alternator to be pivoted, about its offset mounting bracket, to apply the proper tensioning to its installed V belt, to attain its proper operations.

Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.

Abstract: A trailer hitch mounted recycling, transporting, and even a waste container transporting apparatus includes a tubing connector, that secures with the trailer hitch of a vehicle, and having a support plate, that mounts a lifting tube permanently thereon. A pivot rod pivotally secures to the upper end of the lifting tube, and the pivot rod connects with a lifting lever, which when pivoted from a vertical to a horizontal position, allows for movement of a container either onto or off of the ground, in preparation for its transport, or removal from this apparatus. A lifting hook slidably engages with the lifting tube, and connects with a lifting bracket at its upper end, which connects with a short lever, that provides a sliding movement to the lifting hook either upwardly with respect to the lifting tube, or downwardly therefrom, so that its hook device can secure to the container to provide for its lifting, transport, and lowering, after it has been moved to a distant location.

Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.

Abstract: Methods and compositions using an orthosilicate for tissue regeneration, such as to treat a disease or condition, are described, including on the skin. Also described are methods for making such compositions.