Patents by Inventor Thomas E. Wagner

Thomas E. Wagner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220249552
    Abstract: The current invention provides monocytic cells transfected with chimeric antigen receptor (CAR) to selectively home to tumors and upon homing differentiate into dendritic cells capable of activating immunity which is inhibitory to said tumor. In one embodiment of the invention, monocytic cells are transfected with a construct encoding an antigen binding domain, a transcellular or structural domain, and an intracellular signaling domain. In one specific aspect of the invention, the antigen binding domain interacts with sufficient affinity to a tumor antigen, capable of triggering said intracellular domain to induce an activation signal to induce monocyte differentiation into DC.
    Type: Application
    Filed: April 7, 2022
    Publication date: August 11, 2022
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Julia S. Szymanski, Santosh Kesari, Amit N. Patel, Boris Minev
  • Publication number: 20220233586
    Abstract: The current invention provides monocytic cells transfected with chimeric antigen receptor (CAR) to selectively home to tumors and upon homing differentiate into dendritic cells capable of activating immunity which is inhibitory to said tumor. In one embodiment of the invention, monocytic cells are transfected with a construct encoding an antigen binding domain, a transcellular or structural domain, and an intracellular signaling domain. In one specific aspect of the invention, the antigen binding domain interacts with sufficient affinity to a tumor antigen, capable of triggering said intracellular domain to induce an activation signal to induce monocyte differentiation into DC.
    Type: Application
    Filed: April 7, 2022
    Publication date: July 28, 2022
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Julia S. Szymanski, Santosh Kesari, Amit N. Patel, Boris Minev
  • Publication number: 20220202856
    Abstract: The current invention provides monocytic cells transfected with chimeric antigen receptor (CAR) to selectively home to tumors and upon homing differentiate into dendritic cells capable of activating immunity which is inhibitory to said tumor in one embodiment of the invention, monocytic cells are transfected with a construct encoding an antigen binding domain, a transcellular or structural domain, and an intracellular signaling domain. In one specific aspect of the invention, the antigen binding domain interacts with sufficient affinity to a tumor antigen, capable of triggering said intracellular domain to induce an activation signal to induce monocyte differentiation into DC.
    Type: Application
    Filed: February 15, 2022
    Publication date: June 30, 2022
    Inventors: Samuel C. WAGNER, Thomas E. Ichim, Julia S. Szymanski, Santosh Kesari, Amit N. Patel, Boris Minev
  • Publication number: 20220162644
    Abstract: The present disclosure provides delivery vectors for expressing a chimeric receptor in a monocytic cell, such as a macrophage or dendritic cell. The chimeric receptor may specifically bind to a particular antigen or target molecule, such as an immune checkpoint protein or OX40. The disclosed delivery vectors can be used to treat cancer in a subject by expressing in vivo a chimeric receptor on the surface of the subject's monocytic cells.
    Type: Application
    Filed: May 28, 2020
    Publication date: May 26, 2022
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20220151943
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Application
    Filed: November 22, 2021
    Publication date: May 19, 2022
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20210393771
    Abstract: The present disclosure provides particles for delivering a nucleic acid that encodes an immunogenic peptide in an antigen presenting cell. The disclosed particles can function as a vaccine and can be used to treat or prevent a viral or bacterial infection in a subject by expressing in vivo an immunogenic peptide, thereby stimulating the subject's immune system to attack the virus or bacteria that naturally express the immunogenic peptide.
    Type: Application
    Filed: June 23, 2020
    Publication date: December 23, 2021
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Patent number: 11179343
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: November 23, 2021
    Assignee: Orbis Health Solutions, LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20210252052
    Abstract: Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.
    Type: Application
    Filed: December 21, 2020
    Publication date: August 19, 2021
    Applicant: Orbis Health Solutions LLC
    Inventor: Thomas E. WAGNER
  • Patent number: 10960824
    Abstract: A trailer hitch mounted recycling, transporting, and even a waste container transporting apparatus includes a tubing connector, that secures with the trailer hitch of a vehicle, and having a support plate, that mounts a lifting tube permanently thereon. A pivot rod pivotally secures to the upper end of the lifting tube, and the pivot rod connects with a lifting lever, which when pivoted from a vertical to a horizontal position, allows for movement of a container either onto or off of the ground, in preparation for its transport, or removal from this apparatus. A lifting hook slidably engages with the lifting tube, and connects with a lifting bracket at its upper end, which connects with a short lever, that provides a sliding movement to the lifting hook either upwardly with respect to the lifting tube, or downwardly therefrom, so that its hook device can secure to the container to provide for its lifting, transport, and lowering, after it has been moved to a distant location.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: March 30, 2021
    Assignee: Wagner Products Company
    Inventor: Thomas E Wagner
  • Patent number: 10869885
    Abstract: Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: December 22, 2020
    Assignee: Orbis Health Solutions LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20200368172
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Application
    Filed: June 5, 2020
    Publication date: November 26, 2020
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Patent number: 10801041
    Abstract: The present invention relates generally to a gene expression system utilizing an alphavirus replicon and T7 promoter. The system is capable of expressing proteins in the cell cytoplasm without integrating the gene of interest into the genome of a host cell. The invention has a wide range of applications such as producing induced pluripotent cells and vaccines against pathogens and cancers.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: October 13, 2020
    Assignee: Orbis Health Solutions, LLC
    Inventor: Thomas E. Wagner
  • Patent number: 10746265
    Abstract: An adjustable bracket for alternator and related products, including an alternator that adjustably secures with the timing gear cover found on most vehicle engines, an offset mounting bracket securing with the gear cover, and having upwardly extending inclined arms, for connecting with the bottom of the alternator, and a tensioning arm also securing with the timing cover, having an integral bend upwardly towards its linear and arcuate portion, with the arcuate portions of the tensioning arm having a slot formed therein, through which an adjustment bolt secures with the upper part of the alternator, to allow for the alternator to be pivoted, about its offset mounting bracket, to apply the proper tensioning to its installed V belt, to attain its proper operations.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: August 18, 2020
    Assignee: Wagner Products Company
    Inventor: Thomas E Wagner
  • Patent number: 10675249
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 9, 2020
    Assignee: Orbis Health Solutions, LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20200139895
    Abstract: A trailer hitch mounted recycling, transporting, and even a waste container transporting apparatus includes a tubing connector, that secures with the trailer hitch of a vehicle, and having a support plate, that mounts a lifting tube permanently thereon. A pivot rod pivotally secures to the upper end of the lifting tube, and the pivot rod connects with a lifting lever, which when pivoted from a vertical to a horizontal position, allows for movement of a container either onto or off of the ground, in preparation for its transport, or removal from this apparatus. A lifting hook slidably engages with the lifting tube, and connects with a lifting bracket at its upper end, which connects with a short lever, that provides a sliding movement to the lifting hook either upwardly with respect to the lifting tube, or downwardly therefrom, so that its hook device can secure to the container to provide for its lifting, transport, and lowering, after it has been moved to a distant location.
    Type: Application
    Filed: November 1, 2019
    Publication date: May 7, 2020
    Inventor: Thomas E. Wagner
  • Publication number: 20200069596
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Application
    Filed: November 6, 2019
    Publication date: March 5, 2020
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Patent number: 10500219
    Abstract: Methods and compositions using an orthosilicate for tissue regeneration, such as to treat a disease or condition, are described, including on the skin. Also described are methods for making such compositions.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: December 10, 2019
    Assignee: Orbis Health Solutions LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20190365657
    Abstract: The disclosed bead vectors direct entry into a cell of monocytic origin and cause the expression of an extracellular domain of PD-1, an anti-CTLA4 antibody, or an antibody that is specific for a checkpoint protein. The bead vectors can comprise a nucleic acid component, a lysosome evading component and a bead particle that can be phagocytized. The disclosed vectors are useful in various methods of cancer therapy, treatment, and prevention. Due to the ability of monocytic cells to target tumors, the disclosed vectors are particularly well suited for use in anti-tumor applications and directing expression of target genes in tumor-associated macrophages.
    Type: Application
    Filed: August 17, 2017
    Publication date: December 5, 2019
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20190240162
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Application
    Filed: December 20, 2018
    Publication date: August 8, 2019
    Applicant: ORBIS HEALTH SOLUTIONS, LLC
    Inventor: Thomas E. Wagner
  • Patent number: 10188680
    Abstract: Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: January 29, 2019
    Assignee: Orbis Health Solutions LLC
    Inventor: Thomas E. Wagner