Patents by Inventor Thomas Eduard Friedmann

Thomas Eduard Friedmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Host cell modifications that improve peptide production and downstream processing
    Patent number: 7915011
    Abstract: Disrupting the expression of endogenous Escherichia host cell genes gcvA and spr provides mutant host cells having increased heterologous peptide production. The addition of a genetic modification to the coding region of gene yejM further enhances peptide production and facilitates easier downstream processing. Recombinant Escherichia host cells are provided as well as methods of using such host cells for heterologous peptide production.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: March 29, 2011
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Qi Chen, Qiong Cheng, Kevin Michael Croker, Thomas Eduard Friedmann, Kristin Ruebling-Jass
  • HOST CELL MODIFICATIONS THAT IMPROVE PEPTIDE PRODUCTION AND DOWNSTREAM PROCESSING
    Publication number: 20100227361
    Abstract: Disrupting the expression of endogenous Escherichia host cell genes gcvA and spr provides mutant host cells having increased heterologous peptide production. The addition of a genetic modification to the coding region of gene yejM further enhances peptide production and facilitates easier downstream processing. Recombinant Escherichia host cells are provided as well as methods of using such host cells for heterologous peptide production.
    Type: Application
    Filed: October 8, 2009
    Publication date: September 9, 2010
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: QI CHEN, Qiong Cheng, Kevin Michael Croker, Thomas Eduard Friedmann, Kristin Ruebling-Jass