Abstract: A bone implant including a wire mesh support frame having a plurality of interconnected wire members and at least two fastening points in the form of retention eyelets connected to the support frame by at least one of the wire members, and a biocompatible plate formed about the support frame, the plate having a bore associated with each of the retention eyelets.

Abstract: An implant for at least partially filling a bore hole in a bone includes a biocompatible plate and a support structure. The support structure has a ring-shaped inner support frame having an outer surface defining the outer diameter of the inner support frame and an inner surface, and an outer support frame having a plurality of fastening points adapted for attaching the implant to bone surrounding a bore hole in which the plate is inserted. The outer support frame is connected to and extends away from the outer surface of the inner support frame. A method of forming the implant is also provided.

Abstract: A bone implant including a wire mesh support frame having a plurality of interconnected wire members and at least two fastening points in the form of retention eyelets connected to the support frame by at least one of the wire members, and a biocompatible plate formed about the support frame, the plate having a bore associated with each of the retention eyelets.

Abstract: An implant for filling a bore hole in a bone includes: a biocompatible plate having upper and lower surfaces; and a support frame having a central portion located at least partially within the plate, an outer rim having a plurality of fastening points adapted for attaching the implant to bone surrounding a bore hole in which the plate is inserted, and a plurality of arms extending between the central portion and the outer rim.

Abstract: A bone implant including a wire mesh support frame (120A) having a plurality of interconnected wire members and at least two fastening points in the form of retention eyelets (140A) connected to the support frame by deformable retention arms (138A), and a biocompatible plate (112) formed about the support frame, the plate having at least two open cavities (116) therein, wherein each of the retention arms extends out of the plate from or into one of the open cavities. A method for correcting a bone defect in a patient, a mesh support frame for use in a bone implant, and a method of fabricating a bone implant are also provided.

Abstract: A mosaic implant (2010) comprises a mesh support frame comprising a plurality of polygonal support rings (2040 A, B, C) connected by a plurality of struts (2014), and a plurality of mosaic plates (2012). The support rings are positioned within the mosaic plates; the struts extend between adjacent plates. An implant (1510) for filling a bore hole comprises a plate (1512) and a support frame (1520) having a central portion (1522) located at least partially within the plate, a polygonal outer rim (1524) having a plurality of fastening points for attaching the implant to bone surrounding a bore hole, and a plurality of arms (1530) extending between the central portion and the outer rim. The plurality of arms extend inwardly and downwardly away from the outer rim such that the central portion is located below the plane of the outer rim and the upper surface of the plate is flush with or slightly above the upper surface of the outer rim.

Abstract: An active principle for use in prevention or treatment of bacteria-induced infection and disease, wherein the active principle includes a carrier which exhibits a plurality of a scavenger structure which is capable of interacting with bacteria and reducing its growth and/or adhesion to a surface, the scavenger structure including a nucleophilic center complying with the formula X1(—R?—)(—R?)mHn (formula I) where a) X1 is a single-bonded heteroatom selected amongst N, O and S and exhibits a free electron pair, b) m is 0 or 1 and n is 1 or 2, c) —R?— is a bivalent organic group providing attachment to the carrier via one of its free valences and to X1 at the other free valence, and d) R?— is a monovalent organic group attached to the X1 via its free valence.

Abstract: A bone implant including a wire mesh support frame (120A) having a plurality of interconnected wire members and at least two fastening points in the form of retention eyelets (140A) connected to the support frame by deformable retention arms (138A), and a biocompatible plate (112) formed about the support frame, the plate having at least two open cavities (116) therein, wherein each of the retention arms extends out of the plate from or into one of the open cavities. A method for correcting a bone defect in a patient, a mesh support frame for use in a bone implant, and a method of fabricating a bone implant are also provided.

Abstract: A mosaic implant conformable to a curved surface, comprising first and second implant sections coupled along a beam portion extending across a length of the implant, each of the implant sections having—a plurality of biocompatible mosaic plates, and—a plurality of wires which interconnect the plates with one another. The mosaic implant is configured to be deformable such that at least a portion of the mosaic implant is conformable to a curved surface, with the beam portion providing structural support which resists inward deformation of the curved portion of the implant. A kit for forming a mosaic implant is also provided, along with a method for correcting a bone defect in a patient.

Abstract: A method for treating or preventing the symptoms associated with hang over in an individual suffering from or being at risk for such conditions. The method includes the steps of: i) providing the composition of the invention containing AP, and ii) contacting AP with the mediator a) within the individual, or b) separate from the individual.

Abstract: A composition for treating or preventing inflammatory-related conditions includes as an active principle a carrier which exhibits a plurality of a scavenger structure capable of mitigating the activity of a mediator of inflammatory-related conditions. The scavenger structure includes a nucleophilic center complying with the formula X1(—R?—)(—R?)mHn where: a) X1 is a single-bonded heteroatom selected amongst N, O and S and exhibits a free electron pair; b) m is 0 or 1 and n is 1 or 2; c) —R?— is a bivalent organic group providing attachment to the carrier via one of its free valences and to X1 at the other free valence; and d) R?— is a monovalent organic group attached to the X1 via its free valence. A method for treating or preventing inflammatory-related conditions in an individual suffering from such conditions includes: providing the composition; and contacting the mediator within or separate from the individual.

Abstract: A calcium phosphate monetite cement-forming composition comprises a monetite-forming calcium-based precursor powder and from 3 to 30 wt %, based on the weight of the precursor powder, of dicalcium pyrophosphate powder. Monetite cements formed form such compositions may be used in implants for correcting bone defects. Methods for bone defect repair employ implants formed from such monetite cements and slow implant resorption and/or improve in vivo bone induction in a patient.

Abstract: A mosaic implant (2010) comprises a mesh support frame comprising a plurality of polygonal support rings (2040 A, B, C) connected by a plurality of struts (2014), and a plurality of mosaic plates (2012). The support rings are positioned within the mosaic plates; the struts extend between adjacent plates. An implant (1510) for filling a bore hole comprises a plate (1512) and a support frame (1520) having a central portion (1522) located at least partially within the plate, a polygonal outer rim (1524) having a plurality of fastening points for attaching the implant to bone surrounding a bore hole, and a plurality of arms (1530) extending between the central portion and the outer rim. The plurality of arms extend inwardly and downwardly away from the outer rim such that the central portion is located below the plane of the outer rim and the upper surface of the plate is flush with or slightly above the upper surface of the outer rim.

Abstract: A composition, which upon activation, spontaneously forms a cross-linked hydrogel in aqueous liquid, includes: a) a formulation containing a hyluronan (HA-formulation) which includes a hyaluronan backbone (HA backbone) and a plurality of a reactive substituent group (reactive HA substituent) which i) is directly attached to the HA backbone, and ii) exhibits the reactive HA-group, and b) a formulation of a homo-multifunctional cross-linking reagent (CLR-formulation) exhibiting a plurality of a reactive group (reactive CLR-group). The two reactive groups are selected as a pair of counterparts that mutually and selectively react with each other to form a linkage structure. The hydrogel contains a cross-linking structure which a) is attached to the hyaluronan via two or more of the linkage structure and is defined by the reagent. The cross-linking structure exhibits a plurality of hydroxyl groups. The composition can be used in vivo or ex vivo as a support matrix.

Abstract: An implant includes a single moulded implant body and a plurality of wire anchoring arms moulded into and extending substantially laterally from the moulded ceramic implant body for filling a bore hole in a skull. The implant will not only provide filling of the bone defect, but also provide fixation of the bone flap. Methods for forming such implants and methods for using the implants for filing a bore hole in a skull are described.

Abstract: An implant comprises a plurality of discrete biocompatible molded cement mosaic plates of maximum width w and thickness d connected by wire arms molded into and extending substantially laterally from the mosaic plates. Neighboring mosaic plates are separated by a gap of width t, and at least some of the mosaic plates have a hexagon shape.

Abstract: A composition for treating or preventing inflammatory-related conditions includes as an active principle a carrier which exhibits a plurality of a scavenger structure capable of mitigating the activity of a mediator of inflammatory-related conditions. The scavenger structure includes a nucleophilic centre complying with the formula X1(—R?—)(—R?)mHn where: a) X1 is a single-bonded heteroatom selected amongst N, O and S and exhibits a free electron pair; b) m is 0 or 1 and n is 1 or 2; c) -R?- is a bivalent organic group providing attachment to the carrier via one of its free valences and to X1 at the other free valence; and d) R?- is a monovalent organic group attached to the X1 via its free valence. A method for treating or preventing inflammatory-related conditions in an individual suffering from such conditions includes: providing the composition; and contacting the mediator within or separate from the individual.

Abstract: A composition for treating or preventing inflammatory-related conditions includes as an active principle a carrier which exhibits a plurality of a scavenger structure capable of mitigating the activity of a mediator of inflammatory-related conditions. The scavenger structure includes a nucleophilic center complying with the formula X1(—R?—)(—R?)mHn where: a) X1 is a single-bonded heteroatom selected amongst N, O and S and exhibits a free electron pair; b) m is 0 or 1 and n is 1 or 2; c) —R?— is a bivalent organic group providing attachment to the carrier via one of its free valences and to X1 at the other free valence; and d) R?— is a monovalent organic group attached to the X1 via its free valence. A method for treating or preventing inflammatory-related conditions in an individual suffering from such conditions includes: providing the composition; and contacting the mediator within or separate from the individual.

Abstract: A mosaic implant conformable to a curved surface, comprising first and second implant sections coupled along a beam portion extending across a length of the implant, each of the implant sections having—a plurality of biocompatible mosaic plates, and—a plurality of wires which interconnect the plates with one another. The mosaic implant is configured to be deformable such that at least a portion of the mosaic implant is conformable to a curved surface, with the beam portion providing structural support which resists inward deformation of the curved portion of the implant. A kit for forming a mosaic implant is also provided, along with a method for correcting a bone defect in a patient.

Abstract: A mosaic implant conformable to a curved surface, comprising first and second implant sections coupled along a beam portion extending across a length of the implant, each of the implant sections having a plurality of biocompatible mosaic plates, and a plurality of wires which interconnect the plates with one another. The mosaic implant is configured to be deformable such that at least a portion of the mosaic implant is conformable to a curved surface, with the beam portion providing structural support which resists inward deformation of the curved portion of the implant. A kit for forming a mosaic implant is also provided, along with a method for correcting a bone defect in a patient.