Patents by Inventor Thomas Eschenhagen
Thomas Eschenhagen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240018548Abstract: The present invention relates to a gene therapy vector which is useful in the treatment or prevention of hypertrophic cardiomyopathy in a subject in need thereof. The gene therapy vector of the invention comprises a nucleic acid sequence encoding a cardiac sarcomeric protein and a cardiomyocyte-specific promoter which is operably linked to said nucleic acid sequence. The invention furthermore relates to a cell which comprises the gene therapy vector. Pharmaceutical compositions which comprise the gene therapy vector and/or a cell comprising said vector are also provided. In another aspect, the invention relates to a method for treating or preventing hypertrophic cardiomyopathy in a subject by introducing the gene therapy vector of the invention into a subject in need of treatment.Type: ApplicationFiled: August 18, 2023Publication date: January 18, 2024Inventors: Lucie CARRIER, Thomas ESCHENHAGEN, Thomas VOIT, Giulia MEARINI, Oliver MUELLER, Doreen STIMPEL
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Patent number: 11773408Abstract: The present invention relates to a gene therapy vector which is useful in the treatment or prevention of hypertrophic cardiomyopathy in a subject in need thereof. The gene therapy vector of the invention comprises a nucleic acid sequence encoding a cardiac sarcomeric protein and a cardiomyocyte-specific promoter which is operably linked to said nucleic acid sequence. The invention furthermore relates to a cell which comprises the gene therapy vector. Pharmaceutical compositions which comprise the gene therapy vector and/or a cell comprising said vector are also provided. In another aspect, the invention relates to a method for treating or preventing hypertrophic cardiomyopathy in a subject by introducing the gene therapy vector of the invention into a subject in need of treatment.Type: GrantFiled: December 9, 2019Date of Patent: October 3, 2023Inventors: Lucie Carrier, Thomas Eschenhagen, Thomas Voit, Giulia Mearini, Oliver Mueller, Doreen Stimpel
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Publication number: 20230220421Abstract: The present invention relates to a gene therapy vector which is useful in the treatment or prevention of hypertrophic cardiomyopathy in a subject in need thereof. The gene therapy vector of the invention comprises a nucleic acid sequence encoding a cardiac sarcomeric protein and a cardiomyocyte-specific promoter which is operably linked to said nucleic acid sequence. The invention furthermore relates to a cell which comprises the gene therapy vector. Pharmaceutical compositions which comprise the gene therapy vector and/or a cell comprising said vector are also provided. In another aspect, the invention relates to a method for treating or preventing hypertrophic cardiomyopathy in a subject by introducing the gene therapy vector of the invention into a subject in need of treatment.Type: ApplicationFiled: December 29, 2022Publication date: July 13, 2023Inventors: Lucie CARRIER, Thomas ESCHENHAGEN, Thomas VOIT, Giulia MEARINI, Oliver MUELLER, Doreen STIMPEL
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Patent number: 10894946Abstract: The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and a device for preparing the same. Finally, the invention relates to force-generating engineered heart tissue rings derived from human cells and their use in drug screening and target validation assays.Type: GrantFiled: November 6, 2019Date of Patent: January 19, 2021Assignee: Tissue Systems Holding GmbHInventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen
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Publication number: 20200197177Abstract: The invention is directed to a pouch-like construct comprising mammalian tissue which can be used for preventing distension and/or resisting dilation of the heart in a mammal. Preferably, the pouch-like tissue construct has contractile properties. The invention further relates to a method for the preparation of a pouch-like construct comprising mammalian tissue which can be used for the above purposes.Type: ApplicationFiled: November 7, 2019Publication date: June 25, 2020Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen, Yalin Yildirim
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Publication number: 20200140820Abstract: The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and a device for preparing the same. Finally, the invention relates to force-generating engineered heart tissue rings derived from human cells and their use in drug screening and target validation assays.Type: ApplicationFiled: November 6, 2019Publication date: May 7, 2020Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen
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Publication number: 20200095609Abstract: The present invention relates to a gene therapy vector which is useful in the treatment or prevention of hypertrophic cardiomyopathy in a subject in need thereof. The gene therapy vector of the invention comprises a nucleic acid sequence encoding a cardiac sarcomeric protein and a cardiomyocyte-specific promoter which is operably linked to said nucleic acid sequence. The invention furthermore relates to a cell which comprises the gene therapy vector. Pharmaceutical compositions which comprise the gene therapy vector and/or a cell comprising said vector are also provided. In another aspect, the invention relates to a method for treating or preventing hypertrophic cardiomyopathy in a subject by introducing the gene therapy vector of the invention into a subject in need of treatment.Type: ApplicationFiled: December 9, 2019Publication date: March 26, 2020Inventors: Lucie Carrier, Thomas Eschenhagen, Thomas Voit, Giulia Mearini, Oliver Mueller, Doreen Stimpel, Julia Mourot-Filiatre
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Patent number: 10501756Abstract: The present invention relates to a gene therapy vector which is useful in the treatment or prevention of hypertrophic cardiomyopathy in a subject in need thereof. The gene therapy vector of the invention comprises a nucleic acid sequence encoding a cardiac sarcomeric protein and a cardiomyocyte-specific promoter which is operably linked to said nucleic acid sequence. The invention furthermore relates to a cell which comprises the gene therapy vector. Pharmaceutical compositions which comprise the gene therapy vector and/or a cell comprising said vector are also provided. In another aspect, the invention relates to a method for treating or preventing hypertrophic cardiomyopathy in a subject by introducing the gene therapy vector of the invention into a subject in need of treatment.Type: GrantFiled: April 17, 2014Date of Patent: December 10, 2019Assignees: UNIVERSITÄTSKLINIKUM HAMBURG-EPPENDORF, RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG, SORBONNE UNIVERSITÉ, ASSOCIATION INSTITUTE DE MYOLOGIEInventors: Lucie Carrier, Thomas Eschenhagen, Thomas Voit, Giulia Mearini, Oliver Mueller, Doreen Stimpel, Julia Mourot-Filiatre
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Patent number: 10500051Abstract: The invention is directed to a pouch-like construct comprising mammalian tissue which can be used for preventing distension and/or resisting dilation of the heart in a mammal. Preferably, the pouch-like tissue construct has contractile properties. The invention further relates to a method for the preparation of a pouch-like construct comprising mammalian tissue which can be used for the above purposes.Type: GrantFiled: September 21, 2016Date of Patent: December 10, 2019Assignee: UNIVERSITATSKLINIKUM HAMBURG-EPPENDORFInventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen, Yalin Yildirim
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Patent number: 10494605Abstract: The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and a device for preparing the same. Finally, the invention relates to force-generating engineered heart tissue rings derived human cells and their use in drug screening and target validation assays.Type: GrantFiled: March 26, 2018Date of Patent: December 3, 2019Assignee: Tissue Systems Holding GmbHInventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen
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Publication number: 20190062708Abstract: The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and a device for preparing the same. Finally, the invention relates to force-generating engineered heart tissue rings derived from human cells and their use in drug screening and target validation assays.Type: ApplicationFiled: March 26, 2018Publication date: February 28, 2019Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen
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Method and apparatus for measuring contraction characteristics of engineered heart tissue constructs
Patent number: 10172712Abstract: The invention is directed to a novel method for measuring contraction characteristics of engineered heart tissue constructs (16) which is based on the mechanical coupling of the construct (16) to a support element (8) which comprises or is mechanically coupled to a piezoelectric element (10). An apparatus (1) for carrying out the method of the invention is also provided.Type: GrantFiled: March 25, 2014Date of Patent: January 8, 2019Assignees: Universitätsklinikum Hamburg-Eppendorf, Technische Universität Hamburg-HarburgInventors: Thomas Eschenhagen, Ingra Mannhardt, Jörg Müller, Christoph Warncke, Jördis Weiser -
Patent number: 9957483Abstract: The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and a device for preparing the same. Finally, the invention relates to force-generating engineered heart tissue rings derived from human cells and their use in drug screening and target validation assays.Type: GrantFiled: April 9, 2015Date of Patent: May 1, 2018Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen
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Publication number: 20170071739Abstract: The invention is directed to a pouch-like construct comprising mammalian tissue which can be used for preventing distension and/or resisting dilation of the heart in a mammal. Preferably, the pouch-like tissue construct has contractile properties. The invention further relates to a method for the preparation of a pouch-like construct comprising mammalian tissue which can be used for the above purposes.Type: ApplicationFiled: September 21, 2016Publication date: March 16, 2017Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen, Yalin Yildirim
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Publication number: 20160108430Abstract: The present invention relates to a gene therapy vector which is useful in the treatment or prevention of hypertrophic cardiomyopathy in a subject in need thereof. The gene therapy vector of the invention comprises a nucleic acid sequence encoding a cardiac sarcomeric protein and a cardiomyocyte-specific promoter which is operably linked to said nucleic acid sequence. The invention furthermore relates to a cell which comprises the gene therapy vector. Pharmaceutical compositions which comprise the gene therapy vector and/or a cell comprising said vector are also provided. In another aspect, the invention relates to a method for treating or preventing hypertrophic cardiomyopathy in a subject by introducing the gene therapy vector of the invention into a subject in need of treatment.Type: ApplicationFiled: April 17, 2014Publication date: April 21, 2016Inventors: Lucie Carrier, Thomas Eschenhagen, Thomas Voit, Giulia Mearini, Oliver Mueller, Doreen Stimpel, Julia Mourot-Filiatre
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Publication number: 20160075998Abstract: The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and a device for preparing the same. Finally, the invention relates to force-generating engineered heart tissue rings derived from human cells and their use in drug screening and target validation assays.Type: ApplicationFiled: April 9, 2015Publication date: March 17, 2016Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen
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METHOD AND APPARATUS FOR MEASURING CONTRACTION CHARACTERISTICS OF ENGINEERED HEART TISSUE CONSTRUCTS
Publication number: 20160030177Abstract: The invention is directed to a novel method for measuring contraction characteristics of engineered heart tissue constructs (16) which is based on the mechanical coupling of the construct (16) to a support element (8) which comprises or is mechanically coupled to a piezoelectric element (10). An apparatus (1) for carrying out the method of the invention is also provided.Type: ApplicationFiled: March 25, 2014Publication date: February 4, 2016Inventors: Thomas Eschenhagen, Ingra Vollert, Jörg Müller, Christoph Warncke, Jördis Weiser -
Publication number: 20150071888Abstract: The invention is directed to a pouch-like construct comprising mammalian tissue which can be used for preventing distension and/or resisting dilation of the heart in a mammal. Preferably, the pouch-like tissue construct has contractile properties. The invention further relates to a method for the preparation of a pouch-like construct comprising mammalian tissue which can be used for the above purposes.Type: ApplicationFiled: July 7, 2014Publication date: March 12, 2015Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen, Yalin Yildirim
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Publication number: 20100167373Abstract: The invention is directed to a pouch-like construct comprising mammalian tissue which can be used for preventing distension and/or resisting dilation of the heart in a mammal. Preferably, the pouch-like tissue construct has contractile properties. The invention further relates to a method for the preparation of a pouch-like construct comprising mammalian tissue which can be used for the above purposes.Type: ApplicationFiled: November 11, 2007Publication date: July 1, 2010Applicant: UNIVERSITATSKLINIKUM HAMBURG-EPPENDORFInventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen, Yalin Yildirim
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Patent number: 7618452Abstract: The invention relates to a device for producing a three-dimensional circular muscle body from a carrier substance and from cell cultures incorporated therein comprising a cell culture dish (1) and at least one element (2) placed inside said cell culture dish (1). The invention also relates to a multi-well plate constructed of a number of devices, which are arranged side by side and/or one behind the other, for producing a three-dimensional circular muscle body. The invention additionally relates to a solution for cultivating mammal cardiomyocytes, to a method for cultivating a cell culture, to a device for measuring isometric force parameters of cell cultures, and to a method for following, in a measurable manner, contractions of a cell tissue incorporated in a carrier substance. Finally, the invention relates to an artificially produced three-dimensional muscle tissue, in particular, a heart muscle tissue.Type: GrantFiled: January 26, 2001Date of Patent: November 17, 2009Assignee: Medigene AGInventor: Thomas Eschenhagen