Patents by Inventor Thomas Estok

Thomas Estok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATON THERAPY WITH A DON PRODRUG AND AN IMMUNE CHECKPOINT INHIBITOR
    Publication number: 20220117938
    Abstract: The present disclosure provides therapeutic methods of treating a cancer in a subject with isopropyl (S)-2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate or isopropyl (S)-2-((S)-6-acetamido-2-((3S,5S,7S)-adamantane-1-carboxamido)hexanamido)-6-diazo-5-oxohexanoate, or (S)-2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoic acid, or DON and an immune checkpoint inhibitor. The present disclosure also provides intermittent dosing schedules for isopropyl (S)-2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate or isopropyl (S)-2-((S)-6-acetamido-2-((3S,5S,7S)-adamantane-1-carboxamido)hexanamido)-6-diazo-5-oxohexanoate or (S)-2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoic acid for the treatment of cancer.
    Type: Application
    Filed: January 17, 2020
    Publication date: April 21, 2022
    Inventors: ROBERT CHRISTIAN WILD, THOMAS ESTOK
  • Patient Selection and Therapeutic Methods Using Markers of Prostaglandin Metabolism
    Publication number: 20120016002
    Abstract: Disclosed herein are methods related generally to a patient selection process for identifying individuals for treatment of cancer, inflammation, pain, and/or related conditions.
    Type: Application
    Filed: July 11, 2008
    Publication date: January 19, 2012
    Applicant: TRAGARA PHARMACEUTICALS ,Inc.
    Inventors: Tracy Lawhon, Sara L. Zaknoen, Thomas Estok, Mark Green