Abstract: The present disclosure relates to compositions and methods for reducing the concentration of extendable free and buried primers relative to amplification product in a sample. The disclosed methods and compositions can be used to reduce or eliminate index hopping in a next generation sequencing (NGS) platform.

Abstract: This invention provides an improved display system and method that is created by adjusting the properties of one or more displays to obtain coarse control over display behavior, by using sensors to optimize display parameters. The display is further improved by constructing a display map by selectively driving the display and sensing the optical image created. Furthermore, the sensors are used to ensure that the resulting optimized display meets target quality measurements over time, potentially taking into account ambient conditions. The system reports on status, and can predict when it no longer meets a quality target. It is able to optimize a display system and keep it optimized over time. Individual displays with the display system can have operating points that are matched to each other. Corrections to the input image signal, delivering improved display system performance, are minimized, and therefore, unwanted artifacts of those changes can be minimized.

Abstract: In general, one aspect disclosed features a medical device, comprising: a four-way medical stopcock, comprising: a body defining a cock barrel and comprising: a first stem having a first port, a second stem having a second port, and a side stem having a side port; and a rotatable cock disposed within the cock barrel, wherein: the cock places the first port and second port in fluid communication when the cock is in a first position, and the cock places the first port, second port, and side port in fluid communication when the cock is in a second position; and a needleless valve having a valve stem, wherein the valve stem is disposed within the side stem such that an internal volume defined by the side stem, the valve stem, and the cock when the cock is in the third position, is approximately 0.09 ml.

Abstract: In general, one aspect disclosed features a medical device, comprising: a four-way medical stopcock, comprising: a body defining a cock barrel and comprising: a first stem having a first port, a second stem having a second port, and a side stem having a side port; and a rotatable cock disposed within the cock barrel, wherein: the cock places the first port and second port in fluid communication when the cock is in a first position, and the cock places the first port, second port, and side port in fluid communication when the cock is in a second position; and a needleless valve having a valve stem, wherein the valve stem is disposed within the side stem such that an internal volume defined by the side stem, the valve stem, and the cock when the cock is in the third position, is approximately 0.09 ml.

Abstract: Disclosed herein are sterilized medical coiled tubing and process for producing the same. One process comprises: helically winding a length of the medical tubing along a mandrel such that adjacent turns of the medical tubing are in contact with each other; applying solvent where the turns of the medical tubing contact each other to produce coiled medical tubing; allowing the solvent to dry; removing the medical tubing from the mandrel after the solvent has dried; and subjecting the medical tubing to a sterilization process using ethylene oxide with in-chamber aeration.

Abstract: This invention provides an improved display system and method that is created by adjusting the properties of one or more displays to obtain coarse control over display behavior, by using sensors to optimize display parameters. The display is further improved by constructing a display map by selectively driving the display and sensing the optical image created. Furthermore, the sensors are used to ensure that the resulting optimized display meets target quality measurements over time, potentially taking into account ambient conditions. The system reports on status, and can predict when it no longer meets a quality target. It is able to optimize a display system and keep it optimized over time. Individual displays with the display system can have operating points that are matched to each other. Corrections to the input image signal, delivering improved display system performance, are minimized, and therefore, unwanted artifacts of those changes can be minimized.

Abstract: This invention provides an improved display system and method that is created by adjusting the properties of one or more displays to obtain coarse control over display behavior, by using sensors to optimize display parameters. The display is further improved by constructing a display map by selectively driving the display and sensing the optical image created. Furthermore, the sensors are used to ensure that the resulting optimized display meets target quality measurements over time, potentially taking into account ambient conditions. The system reports on its status, and is able to predict when the system will no longer meet a quality target. The system and method is able to optimize a display system and keep it optimized over time. Individual displays with the display system can have operating points that are matched to each other. Corrections to the input image signal to deliver improved display system performance can be minimized, and therefore, the unwanted artifacts of those changes can be minimized.

Abstract: Caps for disinfecting medical devices, and methods of disinfecting medical device using the caps, are disclosed. In general, one aspect disclosed features a cap for disinfecting a medical device, the cap comprising: a cylindrical receiving portion having an opening configured to receive a medical device, the cylindrical receiving portion comprising internal threads configured to mate with external threads of the medical device; disinfectant disposed within the cylindrical receiving portion; a cylindrical stem disposed longitudinally within the cylindrical receiving portion; and an annular sponge disposed about the cylindrical stem and contacting the disinfectant.

Abstract: This invention provides an improved display system and method that is created by adjusting the properties of one or more displays to obtain coarse control over display behavior, by using sensors to optimize display parameters. The display is further improved by constructing a display map by selectively driving the display and sensing the optical image created. Furthermore, the sensors are used to ensure that the resulting optimized display meets target quality measurements over time, potentially taking into account ambient conditions. The system reports on its status, and is able to predict when the system will no longer meet a quality target. The system and method is able to optimize a display system and keep it optimized over time. Individual displays with the display system can have operating points that are matched to each other. Corrections to the input image signal to deliver improved display system performance can be minimized, and therefore, the unwanted artifacts of those changes can be minimized.

Abstract: Disclosed herein are sterilized medical coiled tubing and process for producing the same. One process comprises: helically winding a length of the medical tubing along a mandrel such that adjacent turns of the medical tubing are in contact with each other; applying solvent where the turns of the medical tubing contact each other to produce coiled medical tubing; allowing the solvent to dry; removing the medical tubing from the mandrel after the solvent has dried; and subjecting the medical tubing to a sterilization process using ethylene oxide with in-chamber aeration.

Abstract: Disclosed herein are sterilized medical coiled tubing and process for producing the same. One process comprises: helically winding a length of medical tubing along a mandrel such that adjacent turns of the medical tubing are in contact with each other at tubing contact points; applying a UV adhesive to the tubing contact points to produce a medical coiled tubing; curing the tubing by applying UV light to the tubing contact points; and removing the medical tubing from the mandrel after the solvent has dried.

Abstract: In general, one aspect disclosed features a medical device, comprising: a four-way medical stopcock, comprising: a body defining a cock barrel and comprising: a first stem having a first port, a second stem having a second port, and a side stem having a side port; and a rotatable cock disposed within the cock barrel, wherein: the cock places the first port and second port in fluid communication when the cock is in a first position, and the cock places the first port, second port, and side port in fluid communication when the cock is in a second position; and a needleless valve having a valve stem, wherein the valve stem is disposed within the side stem such that an internal volume defined by the side stem, the valve stem, and the cock when the cock is in the third position, is approximately 0.09 ml.

Abstract: This invention provides an improved display system and method that is created by adjusting the properties of one or more displays to obtain coarse control over display behavior, by using sensors to optimize display parameters. The display is further improved by constructing a display map by selectively driving the display and sensing the optical image created. Furthermore, the sensors are used to ensure that the resulting optimized display meets target quality measurements over time, potentially taking into account ambient conditions. The system reports on its status, and is able to predict when the system will no longer meet a quality target. The system and method is able to optimize a display system and keep it optimized over time. Individual displays with the display system can have operating points that are matched to each other. Corrections to the input image signal to deliver improved display system performance can be minimized, and therefore, the unwanted artifacts of those changes can be minimized.

Abstract: Embodiments of the application are directed toward an enteral feeding connector, comprising a stem member of a male enteral feeding connector configured to fit inside a shroud skirt of a female enteral feeding connector, wherein an end of the stem member comprises a positive taper funnel-shaped opening. In some cases, an outer radial surface of the end of the stem member is shaped to match a profile of an inner radial surface of the shroud skirt, such that the outer radial surface of the end of the stem member is flush with the inner radial surface of the shroud skirt when the stem member is disposed within the shroud skirt.

Abstract: This invention provides an improved display system and method that is created by adjusting the properties of one or more displays to obtain coarse control over display behavior, by using sensors to optimize display parameters. The display is further improved by constructing a display map by selectively driving the display and sensing the optical image created. Furthermore, the sensors are used to ensure that the resulting optimized display meets target quality measurements over time, potentially taking into account ambient conditions. The system reports on its status, and is able to predict when the system will no longer meet a quality target. The system and method is able to optimize a display system and keep it optimized over time. Individual displays with the display system can have operating points that are matched to each other. Corrections to the input image signal to deliver improved display system performance can be minimized, and therefore, the unwanted artifacts of those changes can be minimized.

Abstract: A display system and method created by adjusting the properties of one or more displays to obtain coarse control over display behavior, by using sensors to optimize display parameters and meet a quality target. The display may construct a display map by selectively driving the display and sensing the optical image created. The system reports on its status, and is able to predict when the system will no longer meet a quality target. The system and method may optimize a display system and keep it optimized over time. Operators of the display who require a minimum level of quality for the display system can be ensured that the display meets those requirements. And, they can be warned in advance as to when system maintenance can be necessary, when quality falls below targeted goals system and method provides for sending out methods of the quality of the system.

Abstract: Systems, methods, libraries, kits, and computer software tools are provided for designing and producing engineered cells. Such engineered cells can be used for cell state quantification, such as genome, transcriptome and/or proteome quantification. In one aspect, an engineered cell having a plurality of artificially designed oligonucleotides introduced into the genome of the cell is provided. The oligonucleotides are each located in proximity of a gene of interest encoding a protein of interest, and are different from one another. The oligonucleotides can each encode a unique peptide tag for each protein of interest, wherein each peptide tag has a unique quantitatively measurable value such as mass-to-charge ratio which can be quantified by a mass spectrometer. The engineered cell is capable of expressing a plurality of proteins of interest each fused to its corresponding unique peptide tag, wherein each peptide tag is capable of being released therefrom.

Abstract: Embodiments of the application are directed toward an enteral feeding connector, comprising a stem member of a male enteral feeding connector configured to fit inside a shroud skirt of a female enteral feeding connector, wherein an end of the stem member comprises a positive taper funnel-shaped opening. In some cases, an outer radial surface of the end of the stem member is shaped to match a profile of an inner radial surface of the shroud skirt, such that the outer radial surface of the end of the stem member is flush with the inner radial surface of the shroud skirt when the stem member is disposed within the shroud skirt.

Abstract: Systems, methods, libraries, kits, and computer software tools are provided for designing and producing engineered cells. Such engineered cells can be used for cell state quantification, such as genome, transcriptome and/or proteome quantification. In one aspect, an engineered cell having a plurality of artificially designed oligonucleotides introduced into the genome of the cell is provided. The oligonucleotides are each located in proximity of a gene of interest encoding a protein of interest, and are different from one another. The oligonucleotides can each encode a unique peptide tag for each protein of interest, wherein each peptide tag has a unique quantitatively measurable value such as mass-to-charge ratio which can be quantified by a mass spectrometer. The engineered cell is capable of expressing a plurality of proteins of interest each fused to its corresponding unique peptide tag, wherein each peptide tag is capable of being released therefrom.

Abstract: Systems, methods, libraries, kits, and computer software tools are provided for designing and producing engineered cells. Such engineered cells can be used for cell state quantification, such as genome, transcriptome and/or proteome quantification. In one aspect, an engineered cell having a plurality of artificially designed oligonucleotides introduced into the genome of the cell is provided. The oligonucleotides are each located in proximity of a gene of interest encoding a protein of interest, and are different from one another. The oligonucleotides can each encode a unique peptide tag for each protein of interest, wherein each peptide tag has a unique quantitatively measurable value such as mass-to-charge ratio which can be quantified by a mass spectrometer. The engineered cell is capable of expressing a plurality of proteins of interest each fused to its corresponding unique peptide tag, wherein each peptide tag is capable of being released therefrom.