Patents by Inventor Thomas F. McCutchan

Thomas F. McCutchan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating parasitic infection using thiopeptides
    Patent number: 6313090
    Abstract: The present invention provides a method for treating a parasitic infection in a subject infected with a parasite having a plastid-like organelle, comprising administering to the subject an infection treating amount of a thiopeptide in a pharmaceutically acceptable carrier. Methods for treating Cryptospordium, Toxoplasma or Plasmodium infection in a subject are also provided, each method comprising administering to the subject an infection treating amount of a thiopeptide in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: November 6, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Martin John Rogers, Thomas F. McCutchan, Glenn A. McConkey, Alexandra S. Fairfield
  • Intact gene and method of excising and cloning same
    Patent number: 4707445
    Abstract: The present invention discloses isolated functionally intact whole genes and method of obtaining the same. The method includes treating genomic DNA with mung bean nuclease and formamide under controlled conditions. The invention also discloses cloning of said intact whole genes and a library of such cloned genes or any recombinations thereof. The invention is useful in deriving gene products as m-RNA, S-RNA, t-RNA, polypeptides and the like.
    Type: Grant
    Filed: July 31, 1984
    Date of Patent: November 17, 1987
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Thomas F. McCutchan, John B. Dame
  • Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor
    Patent number: 4707357
    Abstract: An immunologically active substantially pure peptide capable of inducing in human an immune response which is cross reactive with and protective against infection by a malaria parasite, wherein the peptide contains at least 2 consecutive repeats of a sequence Asn-X-Y-Pro wherein X is Ala or Val and Y is Asn or Asp or a sequence of the formula Thr-Glu-Trp-Z-Pro-Cys-Ser-Val-Thr-Cys-Gly-Asn-Gly wherein Z is Ser or Thr or the formula Lys-Pro-S-T-S-Lys-Leu-Lys-Gln-Pro-U-V-Gly-W-Pro wherein S is Lys or Asn, T is His or Glu, U is Gly or Asn, V is As or Glu, and W is Asn or Gln is disclosed along with DNA sequences and various other genetic materials useful in producing these peptides through biological methods.
    Type: Grant
    Filed: June 26, 1984
    Date of Patent: November 17, 1987
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John B. Dame, Jackie L. Williams, Thomas F. McCutchan, Imogene Schneider
  • Protective synthetic peptide against malaria and encoding gene
    Patent number: 4693994
    Abstract: The present invention discloses a synthetic peptide capable of inducing antibodies protective against human malarial infection caused by Plasmodium vivax sporozoites and the cloning of a gene encoding said peptide. The amino acid and nucleotide sequences of the peptide and the gene, respectively, have been determined and described.
    Type: Grant
    Filed: November 19, 1985
    Date of Patent: September 15, 1987
    Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Thomas F. McCutchan, Richard Wistar, Jr.