Patents by Inventor Thomas F. Mich

Thomas F. Mich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Naphthyridine antibacterial agents
    Patent number: 5281612
    Abstract: Novel naphthyridine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
    Type: Grant
    Filed: May 27, 1988
    Date of Patent: January 25, 1994
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
  • Antibacterial agents - II
    Patent number: 5097032
    Abstract: Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: June 13, 1990
    Date of Patent: March 17, 1992
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Thomas F. Mich, Joseph P. Sanchez
  • Ophthalmic use of naphthyridine antibiotics
    Patent number: 4851415
    Abstract: Certain quinolone and naphthyridine antibiotics are useful for treating ocular infections by topical administration.
    Type: Grant
    Filed: June 17, 1987
    Date of Patent: July 25, 1989
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Carl L. Heifetz
  • 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
    Patent number: 4822801
    Abstract: Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: October 20, 1986
    Date of Patent: April 18, 1989
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Thomas F. Mich, Joseph P. Sanchez
  • Antibacterial agents
    Patent number: 4777175
    Abstract: Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: October 11, 1988
    Assignee: Warner-Lambert Company
    Inventors: Townley P. Culbertson, John M. Doma, Thomas F. Mich, Jeffrey B. Nichols
  • Antibacterial agents
    Patent number: 4771054
    Abstract: Novel quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: September 13, 1988
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
  • Opthalmic use of quinolone antibiotics
    Patent number: 4692454
    Abstract: Certain quinolone and naphthyridine antibiotics are useful for treating ocular infections by topical administration.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: September 8, 1987
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Carl L. Heifetz
  • Antibacterial agents
    Patent number: 4665079
    Abstract: Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: January 23, 1985
    Date of Patent: May 12, 1987
    Assignee: Warner-Lambert Company
    Inventors: Townley P. Culbertson, John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
  • 1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine -3-carboxylic acid and their esters, useful as intermediates for preparing the 7-amine substituted naphthyridines
    Patent number: 4663457
    Abstract: 1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids and their esters, which are useful as intermediates for the preparation of compounds which are useful as anti-bacterial agents.
    Type: Grant
    Filed: August 13, 1985
    Date of Patent: May 5, 1987
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Joseph P. Sanchez, John M. Domagala, Ashok K. Trehan
  • Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
    Patent number: 4657913
    Abstract: Novel difluoro-naphthyridine- and trifluoroquinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: April 18, 1985
    Date of Patent: April 14, 1987
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, John M. Domagala, Jeffrey B. Nichols
  • Antibacterial agents
    Patent number: 4638067
    Abstract: Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: January 20, 1987
    Assignee: Warner-Lambert Co.
    Inventors: Townley P. Culbertson, John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
  • 7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents
    Patent number: 4617308
    Abstract: Novel 1-aryl or heteroaryl-6,8-difluoro-1,4-dihydro-7-(3-aminomethyl)pyrrolidinyl- or 7-spiroamino-4-oxo-3-quinolinecarboxylic acids and acid derivatives thereof as antibacterial agents are described as well as methods for their manufacture, formulation and use in treating bacterial infections caused by Gram-negative and Gram-positive bacteria.
    Type: Grant
    Filed: January 25, 1985
    Date of Patent: October 14, 1986
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, John M. Domagala
  • Antibacterial agents III
    Patent number: 4604401
    Abstract: Novel 1-amino-naphthyridine- and quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
    Type: Grant
    Filed: July 20, 1984
    Date of Patent: August 5, 1986
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Townley P. Culbertson, John M. Domagala
  • Antibacterial agents
    Patent number: 4571396
    Abstract: Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: February 18, 1986
    Assignee: Warner-Lambert Company
    Inventors: Marland P. Hutt, Thomas F. Mich, Townley P. Culbertson
  • Antibacterial 1-oxo-benzoquinolizine-2-carboxylic acids
    Patent number: 4550103
    Abstract: Novel 10-amino-9-fluoro- and 9-fluoro-6,7-dihydro-5-methyl-1-oxo-8-(heterocyclyl)1H,5H-benzo (ij)-2-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
    Type: Grant
    Filed: July 20, 1984
    Date of Patent: October 29, 1985
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Townley P. Culbertson
  • Antibacterial thiazolo-quinolines and thiazolo-naphthyridines
    Patent number: 4550104
    Abstract: Novel 7-fluoro-8-heterocyclyl-5-oxo-5H-thiazolo (3,2-a)-naphthyridine- and quinoline- 4-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
    Type: Grant
    Filed: July 20, 1984
    Date of Patent: October 29, 1985
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Joseph P. Sanchez
  • Antibacterial amide compounds and pharmaceutical compositions containing the same
    Patent number: 4315933
    Abstract: Novel organic amide compounds which are N-[2-(acylaminophenyl)-4-hydroxy-5-pyrimidinylcarbonyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-2-(acylaminophenyl)-4-hydroxy-5-pyrimidine carboxylic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[2-(acylaminophenyl)-4-hydroxy-5-pyrimidinylcarbonyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.
    Type: Grant
    Filed: September 24, 1980
    Date of Patent: February 16, 1982
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Theodore H. Haskell, Marland P. Hutt, Jr.
  • Antibacterial amide compounds
    Patent number: 4315858
    Abstract: Novel organic amide compounds which are N-[6-(acylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[acylaminophenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[acylaminophenyl]-1,2-dihydro-2-oxonicotinoyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.
    Type: Grant
    Filed: September 24, 1980
    Date of Patent: February 16, 1982
    Assignee: Warner-Lambert Company
    Inventors: Leonard Doub, Theodore H. Haskell, Thomas F. Mich, Dietrich Schweiss
  • Antibacterial amide compounds and pharmaceutical composition containing the same
    Patent number: 4315014
    Abstract: Novel organic amide compounds which are N-[6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.
    Type: Grant
    Filed: September 24, 1980
    Date of Patent: February 9, 1982
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Leonard Doub
  • Aminoacid derivatives of cephalosporin compounds
    Patent number: 4311698
    Abstract: Novel organic amide compounds which are N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl]cephalosporin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate cephalosporin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 7-aminocephalosporanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.
    Type: Grant
    Filed: January 31, 1980
    Date of Patent: January 19, 1982
    Inventors: Theodore H. Haskell, Thomas F. Mich, Dietrich Schweiss, Townley P. Culbertson