Patents by Inventor Thomas F. Parsons

Thomas F. Parsons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterodimeric osteogenic factor
    Patent number: 5508263
    Abstract: The present invention provides osteogenically active protein preparations comprising a heterodimer of P3 OF 31-34 subunit B and P3 OF 31-34 subunit D, which subunits are linked with at least one disulfide bond and methods for their preparation. The invention further provides cell lines transformed with nucleotide sequences encoding P3 OF 31-34 subunit B and P3 OF 31-34 subunit D and vectors comprising those sequences in operative association with an expression control sequence.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: April 16, 1996
    Assignee: Xoma Corporation
    Inventors: Lynn Grinna, Georgia Theofan, Thomas F. Parsons
  • Heterodimeric osteogenic factor
    Patent number: 5411941
    Abstract: The present invention provides osteogenically active protein preparations comprising a heterodimer of P3 OF 31-34 subunit B and P3 OF 31-34 subunit D, which subunits are linked with at least one disulfide bond and methods for their preparation. The invention further provides cell lines transformed with nucleotide sequences encoding P3 OF 31-34 subunit B and P3 OF 31-34 subunit D and vectors comprising those sequences in operative association with an expression control sequence.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: May 2, 1995
    Assignee: XOMA Corporation
    Inventors: Lynn Grinna, Georgia Theofan, Thomas F. Parsons
  • Heterodimeric osteogenic factor
    Patent number: 5284756
    Abstract: The present invention provides osteogenically active protein preparations comprising a heterodimer of P3 OF 31-34 subunit B and P3 OF 31-34 subunit D, which subunits are linked with at least one disulfide bond and methods for their preparation. The invention further provides cell lines transformed with nucleotide sequences encoding P3 OF 31-34 subunit B and P3 OF 31-34 subunit D and vectors comprising those sequences in operative association with an expression control sequence.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: February 8, 1994
    Inventors: Lynn Grinna, Georgia Theofan, Thomas F. Parsons
  • Osteogenic factors
    Patent number: 5106626
    Abstract: The present invention provides an osteogenically active protein preparation characterized by a molecular weight of from about 31,000 to 34,000 daltons as characterized comprising a subunit identical to or homologous to a subunit in P3 OF 31-34, by non-reducing sodium dodecyl sulfate polyacrylamide gel electrophoresis and by the characteristic of eluting from a reverse phase high performance liquid chromatography column equilibrated with buffers containing trifluoroacetic acid and acetonitrile by eluting within the concentrations of 35% to 45% acetonitrile. The invention further provides improved methods for isolating such preparations and genes encoding all or a portion of polypeptide subunits of dimers comprising the osteogenic protein preparation.
    Type: Grant
    Filed: October 4, 1989
    Date of Patent: April 21, 1992
    Assignee: International Genetic Engineering, Inc.
    Inventors: Thomas F. Parsons, Arup Sen, Lynn Grinna, Carol Hersh, Georgia Theofan