Patents by Inventor Thomas F. Vogt

Thomas F. Vogt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090007283
    Abstract: Non-human transgenic animals, such as transgenic mice, are generated which incorporate the a non-native form of the bradykinin B1 receptor gene against a null phenotype for the native form of the bradykinin B1 receptor. An exemplified portion of the invention disclosed a transgenic mouse wherein a targeting construct containing a transgene encoding the human B1 bradykinin receptor gene is inserted downstream of and operatively linked to the native mice bradykinin B1 promoter. This targeting construct also contains a fluxed neomycin resistance gene. The resulting transgenic animals are “humanized” for the bradykinin B1 receptor and are effectively on a null background for native, functional B1 receptor activity. These animals may be crossed with a Cre-deleter strain to generate transgenic offspring which absent of the floxed marker gene.
    Type: Application
    Filed: October 4, 2004
    Publication date: January 1, 2009
    Inventors: John W. Hess, Robert J. Gould, Douglas J. Pettibone, Thomas F. Vogt, Richard Z. Chen
  • Patent number: 7432414
    Abstract: The present invention provides transgenic animals having an amyloid precursor protein wherein the amino acids flanking the &bgr; secretase cleavage site are NF and EV. The invention also provides tissues and cell lines derived from such animals. The invention further provides methods of screening candidate compounds to determine whether the compounds can alter the rate of cleavage of amyloid precursor protein by &bgr; secretase.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: October 7, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Richard Z. Chen, Adam J. Simon, Thomas F. Vogt