Patents by Inventor Thomas F. White
Thomas F. White has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230134425Abstract: Disclosed herein are methods and compounds for treating glioblastoma with iniparib. Also disclosed herein is a method of selecting subjects having a glioblastoma for treatment based on a biomarker panel.Type: ApplicationFiled: September 2, 2022Publication date: May 4, 2023Inventor: Thomas F. WHITE
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Patent number: 11628144Abstract: Disclosed herein are pharmaceutical compositions, formulations, and dosage forms and their use in the treatment of a cancer. Also disclosed herein are methods of treating a cancer in a subject in need thereof.Type: GrantFiled: September 28, 2018Date of Patent: April 18, 2023Assignee: TRIACT THERAPEUTICS, INC.Inventors: Thomas F. White, Stephen M. Nava
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Patent number: 11433075Abstract: Disclosed herein are methods and compounds for treating glioblastoma with iniparib. Also disclosed herein is a method of selecting subjects having a glioblastoma for treatment based on a biomarker panel.Type: GrantFiled: January 19, 2021Date of Patent: September 6, 2022Assignee: TRIACT THERAPEUTICS, INC.Inventor: Thomas F. White
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Patent number: 11433074Abstract: Disclosed herein are methods and compounds for treating glioblastoma with iniparib. Also disclosed herein is a method of selecting subjects having a glioblastoma for treatment based on a biomarker panel.Type: GrantFiled: June 22, 2018Date of Patent: September 6, 2022Assignee: TRIACT THERAPEUTICS, INC.Inventor: Thomas F. White
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Publication number: 20210137929Abstract: Disclosed herein are methods and compounds for treating glioblastoma with iniparib. Also disclosed herein is a method of selecting subjects having a glioblastoma for treatment based on a biomarker panel.Type: ApplicationFiled: January 19, 2021Publication date: May 13, 2021Inventor: Thomas F. WHITE
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Patent number: 10943298Abstract: A system and method for assisting users in selecting and prioritizing financial or business goals, and determining a cash flow designed to meet those goals. The user provides, or authorizes the provision of, financial information, which is used by the system to calculate an initial cash flow. The system actively assists the user in selecting and planning for a variety of financial goals, automatically calculates and determines the financial requirements to achieve each of the goals, structures financial products or plans for each goal, and determines whether the user has sufficient assets and/or cash flow to fund or achieve the goals. Goals are prioritized according to a set of business rules, and cash flow elements and goals can be modified or changed according to a variety of business rules in order to fund or achieve the goals.Type: GrantFiled: March 15, 2013Date of Patent: March 9, 2021Inventor: Thomas F. White
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Publication number: 20200297644Abstract: Disclosed herein are pharmaceutical compositions, formulations, and dosage forms and their use in the treatment of a cancer. Also disclosed herein are methods of treating a cancer in a subject in need thereof.Type: ApplicationFiled: September 28, 2018Publication date: September 24, 2020Inventors: Thomas F. WHITE, Stephen M. NAVA
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Publication number: 20200113852Abstract: Disclosed herein are methods and compounds for treating a cancer is characterized with an elevated expression of thioredoxin reductase (TrxR) or an elevated expression of peroxiredoxin (PRDX). In some embodiments, also disclosed herein are methods of selecting subjects for treatment or monitoring the treatment progress based on a biomarker panel.Type: ApplicationFiled: June 22, 2018Publication date: April 16, 2020Inventor: Thomas F. WHITE
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Publication number: 20200113909Abstract: Disclosed herein are methods and compounds for treating glioblastoma with iniparib. Also disclosed herein is a method of selecting subjects having a glioblastoma for treatment based on a biomarker panel.Type: ApplicationFiled: June 22, 2018Publication date: April 16, 2020Inventor: Thomas F. WHITE
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Patent number: 9834575Abstract: The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor metabolite. Catecholic butane metabolites can serve as dual kinase inhibitors for purposes of methods described herein.Type: GrantFiled: February 26, 2014Date of Patent: December 5, 2017Assignee: TRIACT THERAPEUTICS, INC.Inventors: Thomas F. White, Steven Smith
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Patent number: 9381246Abstract: The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic butanes cane serve as dual kinase inhibitors for purposes of methods described herein. Patients to be treated include those that have been treated with Tarceva or other therapeutic compounds and relapsed or are resistant to treatment. The compounds described herein may exhibit a synergistic effect when administered with another agent.Type: GrantFiled: September 9, 2014Date of Patent: July 5, 2016Assignee: Triact Therapeutics, Inc.Inventors: Thomas F. White, Dan Hoth
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Publication number: 20150071919Abstract: The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic butanes cane serve as dual kinase inhibitors for purposes of methods described herein. Patients to be treated include those that have been treated with Tarceva or other therapeutic compounds and relapsed or are resistant to treatment. The compounds described herein may exhibit a synergistic effect when administered with another agent.Type: ApplicationFiled: September 9, 2014Publication date: March 12, 2015Inventors: Thomas F. WHITE, Dan HOTH
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Publication number: 20140249099Abstract: The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor metabolite. Catecholic butane metabolites can serve as dual kinase inhibitors for purposes of methods described herein.Type: ApplicationFiled: February 26, 2014Publication date: September 4, 2014Applicant: TriAct Therapeutics, Inc.Inventors: Thomas F. WHITE, Steven SMITH
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Publication number: 20140235714Abstract: The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic butanes cane serve as dual kinase inhibitors for purposes of methods described herein. Subjects can be further treated by co-administering an EGFR inhibitor. The present application also relates to analyzing a sample with respect to levels of IGF-1R and EGFR and comparing levels of IGF-1R and EGFR to a control. Patients can be selected for treatment with a catecholic butane based on the assessment; optionally, patients can be further treated with an EGFR inhibitor, an IGF-1R inhibitor, or both.Type: ApplicationFiled: April 25, 2014Publication date: August 21, 2014Applicant: TriAct Therapeutics, Inc.Inventors: Thomas F. WHITE, Edward F. SCHNIPPER, Dan HOTH
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Patent number: 8710104Abstract: The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic butanes cane serve as dual kinase inhibitors for purposes of methods described herein. Subjects can be further treated by co-administering an EGFR inhibitor. The present application also relates to analyzing a sample with respect to levels of IGF-1R and EGFR and comparing levels of IGF-1R and EGFR to a control. Patients can be selected for treatment with a catecholic butane based on the assessment; optionally, patients can be further treated with an EGFR inhibitor, an IGF-1R inhibitor, or both.Type: GrantFiled: November 6, 2009Date of Patent: April 29, 2014Assignee: Triact Therapeutics, Inc.Inventors: Thomas F. White, Edward F. Schnipper, Dan Hoth
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Patent number: 8074469Abstract: A refrigerator includes a first compartment, a second compartment and a multi-functional compartment that is disposed between the first compartment and the second compartment and is adjustable between temperature modes selected from the group consisting of a fresh food temperature mode, a soft freeze mode, a freezer mode and a chiller temperature mode.Type: GrantFiled: December 31, 2008Date of Patent: December 13, 2011Assignee: General Electric CompanyInventors: Timothy Allen Hamel, Rita Barksdale, Chris George Bissig, John R. Brumleve, Jonathan Crosby, Rajesh Swarnkar, Thomas F. White, Martin Mitchell Zentner
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Publication number: 20100256232Abstract: The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic butanes cane serve as dual kinase inhibitors for purposes of methods described herein. Subjects can be further treated by co-administering an EGFR inhibitor. The present application also relates to analyzing a sample with respect to levels of IGF-1R and EGFR and comparing levels of IGF-1R and EGFR to a control. Patients can be selected for treatment with a catecholic butane based on the assessment; optionally, patients can be further treated with an EGFR inhibitor, an IGF-1R inhibitor, or both.Type: ApplicationFiled: November 6, 2009Publication date: October 7, 2010Inventors: Thomas F. White, Edward F. Schnipper, Dan Hoth
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Publication number: 20100162747Abstract: A refrigerator includes a first compartment, a second compartment and a multi-functional compartment that is disposed between the first compartment and the second compartment and is adjustable between temperature modes selected from the group consisting of a fresh food temperature mode, a soft freeze mode, a freezer mode and a chiller temperature mode.Type: ApplicationFiled: December 31, 2008Publication date: July 1, 2010Inventors: Timothy Allen HAMEL, Rita Barksdale, Chris George Bissig, John R. Brumleve, Jonathan Crosby, Rajesh Swarnkar, Thomas F. White, Martin Mitchell Zentner