Patents by Inventor Thomas F. Woolf

Thomas F. Woolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions containing Bergamottin for increasing the oral bioavailability of pharmaceutical agents
    Patent number: 6509371
    Abstract: Bergamottin, principle compound in grapefruit juice responsible for inhibition of p450 3a4, the predominant p450 enzyme in the intestine, is coadministered with a compound having low bioavailability to a patient to increase oral bioavailability of the compound and pharmaceutical compositions of the same, as well as a method of isolating bg from grapefruit juice.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: January 21, 2003
    Assignee: Warner-Lambert Company
    Inventors: Kan He, Paul F. Hollenberg, Thomas F. Woolf
  • Tacrine and cytochrome P450 oxidase inhibitors and methods of use
    Patent number: 5466696
    Abstract: Described is a method of treating Alzheimer's disease in a patient comprising administering to said patient an effective amount of tacrine in combination with a P450 1A2 oxidase inhibitor. Preferably, the inhibitor is a heterocyclic guanidine.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: November 14, 1995
    Assignee: Warner Lambert Company
    Inventor: Thomas F. Woolf
  • Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
    Patent number: 5422350
    Abstract: Described is a method of inhibiting the enzymatic metabolism of nitrogen substituted acridines of Formula 1 comprising co-administering with the acridine an effective oxidase inhibiting amount of a P450 1A2 inhibitor. The oxidase is one whose activity is induced by beta-naphthaflavone, 3-methylcholanthrene, arochlor, 2,3,7,8-tetrachlorodibenzo-p-dioxin and isosafrole. The oxidase inhibitor may be a naphthyridine, a xanthine, a phenoxy amino alkane, a carbamoyl imidazole, a heterocyclic guanidine, or a quinoline.
    Type: Grant
    Filed: September 10, 1992
    Date of Patent: June 6, 1995
    Assignee: Warner-Lambert Company
    Inventor: Thomas F. Woolf