Abstract: The invention concerns a system and method for generating a 3D imaging data set of an object or of at least two elements, including: obtaining a 3D image data set of the object or the at least two elements in a first shape, first absolute position, or first relative position, moving at least one of the elements and/or deforming the object to have a second shape, second absolute position, or second relative position, different from the first shape, first absolute position, or first relative position; obtaining a 2D data set of the object or the at least two elements while in the second shape, second absolute position, or second relative position; and calculating a 3D image data set of the object or the at least two elements in the second shape, absolute, or relative position using said 2D image data set and said 3D image data set. The method also may be performed by obtaining the 2D image data set in the first position and obtaining the 3D image data set in the second position.