Abstract: A pump system comprises a longitudinal axis and a plurality of pump stages. Each pump stage comprises a rotary component rotatable about the longitudinal axis, a fluid inlet, a fluid outlet, and a main fluid flow path for fluid to flow from the fluid inlet to the fluid outlet. The rotary component extends radially into the main fluid flow path and is drivable to rotate about the longitudinal axis so as to impart a force to fluid in the main flow path. The rotary component of each of the plurality of pump stages is separately drivable so as to be able to rotate at a different speed from the rotary components of the other pump stages. The pump system further comprises a cooling passage, where the first pump stage is configured to pump fluid through the cooling passage to deliver the fluid to the other pump.

Abstract: The present disclosure relates to a computer-implemented method of predicting and/or detecting the presence of a lesion in a human or animal tissue, the method comprising: identifying a tissue type based on image data of the human or animal tissue using a first model, and predicting and/or detecting the presence of a lesion in the tissue based on the image data and the tissue type using a second model.

Abstract: A method for identifying a type of choroidal neovascularization in a retina of a human eye is disclosed, the method comprising receiving, in a processor, optical coherence tomography data of the eye; generating, in the processor, volume segments of the eye using the optical coherence tomography data and a neural network; and identifying, in the processor, the type of choroidal neovascularization in the eye, using the volume segments, the type of choroidal neovascularization comprising one or more of the following: classic choroidal neovascularization and occult choroidal neovascularization.

Abstract: Systems and methods for performing automated retinal segmentation. Performing the automated retinal segmentation includes receiving an image input for a retina of a subject. Layer element data is generated using the image input and a first neural network. The layer element data identifying a set of retinal layer elements. Initial pathological element data is generated using the image input and a second neural network. The initial pathological element data identifies a set of retinal pathological elements. The initial pathological element data is refined using the layer element data to generate refined pathological element data. The refined pathological element data more accurately identifies the set of retinal pathological elements as compared to the initial pathological element data.

Abstract: Provided herein is a method for processing a liquid sample, utilizing a first component including an interface side and at least 3 sample containers or tanks; and a second component including a connector manifold. The method may include the step of reversibly connecting a reagent container, a filtration apparatus, and a chromatography apparatus to the manifold; reversibly connecting the first component to the connector manifold; pressurizing the first sample tank; transferring the sample into the filtration apparatus; passing the sample through a filter; transferring the sample into the second sample tank; transferring the sample into the chromatography apparatus; transferring the reagent into the chromatography apparatus; and transferring the sample to the third sample tank. Some or all transfers may be routed via the connector manifold and the interface side.

Abstract: Provided herein is a method for sterile fluid transfer. A first array of conduits may be disposed in a first compartment having a planar face with an array of cavities, each containing a cannular protrusion fluidly connected to a conduit. A second array of conduits may be disposed in a second compartment having its own planar face with an array of surface cannular protrusions, each fluidly connected to a conduit in the second array. The method may include sterilizing the lumens of each conduit-protrusion pair; snugly juxtaposing the two planar faces to form an array of steam-tight chambers; introducing a sterilizing gas into the chambers; expelling the sterilizing gas from the chambers; moving each cannular protrusion towards its facing surface protrusion to reversibly form a fluid connection therebetween, while the chamber remains externally sealed, and transferring a fluid across at least one fluidic connection.

Abstract: A multistage pump for installation on a sea ground includes a common housing, a pump unit arranged in the common housing, a drive unit arranged in the common housing, and a coupling. The common housing includes a pump inlet and a pump outlet, the pump unit including a plurality of impellers to convey a compressible fluid from the pump inlet to the pump outlet, and a pump shaft, on which each impeller is mounted, each impeller being a radial or semi-axial impeller. The drive unit includes a drive shaft to drive the pump shaft, and an electric motor configured to rotate the drive shaft about an axial direction. The coupling couples the drive shaft to the pump shaft. The pump unit conveys the fluid in a dense phase at the pump outlet, and at least two impellers of the plurality of impellers have a different specific speed.

Abstract: The present invention relates to a novel waist cape device. The device is a unique fashion accessory with versatile functions which is placed over clothing. The waist cape device comprises a cape component which is fastened around a user's waist area via a belt, straps, buttons, snaps, clips, etc. The cape component comprises drapery panel components on the back, front, and/or both sides, as desired. Embellishments can be added to the cape component. The device can be manufactured using any type of fabric material, leather, chains, vinyl, plastics, PVC, etc. The length of the cape component can be altered depending on the needs and/or wants of a user. The device can also comprise at least one pocket integrated within the cape component.

Abstract: Provided herein is a method for incubating living cells, in accordance with principles of the disclosure, may include the steps of: (a) providing a pressurized gas to a medium reservoir, the pressurized gas providing an impetus that moves a growth medium in the medium reservoir to a bioreactor chamber via a first incoming fluid line connecting the medium reservoir to the bioreactor chamber; (b) simultaneously or subsequently to step (a), providing a pressurized gas to a cell reservoir holding a suspension of the living cells, the pressurized gas providing an impetus that moves the suspension to the bioreactor chamber via a second incoming fluid line connecting the cell reservoir to the bioreactor chamber; and (c) incubating the growth medium and the living cells in the bioreactor chamber, under conditions compatible with cell viability.

Abstract: A method for operating a pump, for conveying a fluid from a low-pressure side to a high-pressure side of the pump includes determining a current rate of change of pump vibrations and comparing the current rate of change with a limit for the rate of change or determining a current vibration of the pump and comparing the current vibration with a vibration amplitude limit for the vibration, storing the limit for the rate of change or the vibration amplitude limit in a surge controller, providing a control signal when the current rate of change reaches the limit or when the current vibration reaches the vibration amplitude limit, and changing a control variable of the pump by the control signal, such that the vibration is reduced and an unstable operating state of the pump is avoided.

Abstract: A method for identifying a type of choroidal neovascularization in a retina of a human eye is disclosed, the method comprising receiving, in a processor, optical coherence tomography data of the eye; generating, in the processor, volume segments of the eye using the optical coherence tomography data and a neural network; and identifying, in the processor, the type of choroidal neovascularization in the eye, using the volume segments, the type of choroidal neovascularization comprising one or more of the following: classic choroidal neovascularization and occult choroidal neovascularization.

Abstract: Methods and systems disclosed herein relate generally to systems and methods for predicting a future visual acuity of a subject by using machine-learning models. An image of at least part of a retina of a subject can be processed by one or more first machine-learning models to detect a set of retina-related segments. Segment-specific metrics that characterize a retina-related segment of the set of retina-related segments can be generated. The segment-specific metrics can be processed by using a second machine-learning model to generate a result corresponding to a prediction corresponding to a future visual acuity of the subject.

Abstract: A process fluid lubricated pump includes a pump having a pump shaft extending from a drive end to a non-drive end to rotate about an axial direction, a first pump section having a first set of impellers fixedly mounted on the pump shaft to increase the pressure of the process fluid, a drive to exert a torque on the drive end of the pump shaft to drive the rotation of the pump shaft, a first balance drum fixedly connected to the pump shaft between the pump and the drive end of the pump shaft, the first balance drum defining a first front side facing the pump and a first back side, and a second balance drum fixedly connected to the pump shaft between the pump and the non-drive end of the pump shaft, the second balance drum defining a second front side facing the pump and a second back side.

Abstract: A method for operating a pump, for conveying a fluid from a low-pressure side to a high-pressure side of the pump includes determining a current rate of change of pump vibrations and comparing the current rate of change with a limit for the rate of change or determining a current vibration of the pump and comparing the current vibration with a vibration amplitude limit for the vibration, storing the limit for the rate of change or the vibration amplitude limit in a surge controller, providing a control signal when the current rate of change reaches the limit or when the current vibration reaches the vibration amplitude limit, and changing a control variable of the pump by the control signal, such that the vibration is reduced and an unstable operating state of the pump is avoided.

Abstract: A multistage pump for installation on a sea ground includes a common housing, a pump unit arranged in the common housing, a drive unit arranged in the common housing, and a coupling. The common housing includes a pump inlet and a pump outlet, the pump unit including a plurality of impellers to convey a compressible fluid from the pump inlet to the pump outlet, and a pump shaft, on which each impeller is mounted, each impellepr being a radial or semi-axial impeller. The drive unit includes a drive shaft to drive the pump shaft, and an electric motor configured to rotate the drive shaft about an axial direction. The coupling couples the drive shaft to the pump shaft. The pump unit conveys the fluid in a dense phase at the pump outlet, and at least two impellers of the plurality of impellers have a different specific speed.

Abstract: A centrifugal pump for conveying a process fluid, includes a pump unit, a drive unit to drive the pump unit, a pump inlet to receive the process fluid, a pump outlet to discharge the process fluid. The pump unit includes an impeller configured to convey the process fluid from the pump inlet to the pump outlet, and a pump shaft, on which the impeller is mounted. The drive unit includes a drive shaft to drive the pump shaft, and an electric motor to rotate the drive shaft about an axial direction. A plurality of bearings is configured to support the pump shaft and the drive shaft, and a hydrodynamic coupling has a casing and is configured to hydrodynamically couple the drive shaft to the pump shaft by a transmission fluid. At least one of the plurality of bearings is arranged in the casing of the hydrodynamic coupling.

Abstract: A process fluid lubricated pump for conveying a process fluid, includes a common housing, a pump unit arranged in the common housing, a drive unit arranged in the common housing, and a hydrodynamic coupling. The common housing includes a pump inlet and a pump outlet for the process fluid. The pump unit includes at least one impeller configured to convey the process fluid from the pump inlet to the pump outlet, and a pump shaft, on which the impeller is mounted. The drive unit includes a drive shaft configured to drive the pump shaft, and an electric motor configured to rotate the drive shaft about an axial direction. The hydrodynamic coupling is configured to hydrodynamically couple the drive shaft to the pump shaft by a transmission fluid, and is configured to receive the process fluid as the transmission fluid.

Abstract: A process fluid lubricated pump includes a pump having a pump shaft extending from a drive end to a non-drive end to rotate about an axial direction, a first pump section having a first set of impellers fixedly mounted on the pump shaft to increase the pressure of the process fluid, a drive to exert a torque on the drive end of the pump shaft to drive the rotation of the pump shaft, a first balance drum fixedly connected to the pump shaft between the pump and the drive end of the pump shaft, the first balance drum defining a first front side facing the pump and a first back side, and a second balance drum fixedly connected to the pump shaft between the pump and the non-drive end of the pump shaft, the second balance drum defining a second front side facing the pump and a second back side.

Abstract: A rotary machine for conveying a fluid includes a drive unit configured to drive a shaft, an impeller arranged at the shaft, and configured to convey the fluid, at least one mechanical seal configured to seal the shaft, a first and a second heat exchange system configured to cool or heat the mechanical seal, the first heat exchange system configured for direct application of a fluid heat carrier at the mechanical seal and the second heat exchange system comprising a heat exchange jacket capable of having a fluid heat carrier flow therethrough without direct contact with the mechanical seal, the first and the second heat exchange systems forming a common heat exchange system in which a common fluid heat carrier is capable of being circulated, and a fan wheel configured to circulate the common fluid heat carrier in the common heat exchange system.

Abstract: A pump includes a housing having an inlet and an outlet configured to convey fluid, an impeller configured to convey the fluid from the inlet to the outlet, the impeller being arranged on a rotatable shaft, and a balance drum configured to relieve axial thrust. The balance drum includes a rotor rotationally fixedly connected to the shaft, the rotor having a high and low pressure sides, a stator stationary with respect to the housing, a relief passage extending between the rotor and the stator from the high pressure side up to the low pressure side of the rotor, a return passage connecting the low pressure side of the rotor to the inlet. An intermediate passage opens into the relief passage between the high pressure side and the low pressure side of the rotor. A blocking member is configured to influence the flow through the intermediate passage.