Patents by Inventor Thomas Fleck

Thomas Fleck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL TETRAZOLES
    Publication number: 20240101561
    Abstract: This invention relates to tetrazoles and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
    Type: Application
    Filed: October 14, 2020
    Publication date: March 28, 2024
    Inventors: Martin Thomas FLECK, Florian Paul Christian BINDER, Georg DAHMANN, Joerg P. HEHN, Uta Friederike LESSEL, Jens WILLWACHER
  • Tetrazole derivatives as TRPA1 inhibitors
    Patent number: 11891403
    Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: February 6, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Thomas Fleck, Florian Paul Christian Binder, Jens Willwacher
  • Tetrazole derivatives as TRPA1 inhibitors
    Patent number: 11884652
    Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: January 30, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Florian Paul Christian Binder, Martin Thomas Fleck, Jens Willwacher
  • 3H,4H,5H,6H,7H-pyrimido[4,5-b][1,4]oxazine-4,6-dione derivatives as TRPA1 inhibitors
    Patent number: 11884681
    Abstract: The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5-b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: January 30, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Thomas Fleck, Florian Paul Christian Binder
  • Substituted 1,2,4-oxadiazoles as TRPA1 inhibitors
    Patent number: 11878981
    Abstract: The present disclosure provides certain substituted 1,2,4-oxadiazole derivatives of the below formula (I) that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: January 23, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Florian Paul Christian Binder, Georg Dahmann, Martin Thomas Fleck, Annekatrin Charlotte Heimann, Thorsten Oost
  • Uracil derivatives as TRPA1 inhibitors
    Patent number: 11858921
    Abstract: The present disclosure provides certain uracil derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: January 2, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Florian Paul Christian Binder, Martin Thomas Fleck, Jens Willwacher
  • HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS
    Publication number: 20230295112
    Abstract: The present invention encompasses compounds of the formula I which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
    Type: Application
    Filed: November 2, 2022
    Publication date: September 21, 2023
    Inventors: Martin Thomas FLECK, Cedrickx GODBOUT, Hannes Fiepko KOOLMAN
  • Tetrazole derivatives as TRPA1 inhibitors
    Patent number: 11661427
    Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing the same.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: May 30, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Thomas Fleck, Florian Paul Christian Binder, Jens Willwacher
  • Thienopyrimidones
    Patent number: 11578080
    Abstract: This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: February 14, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Thomas Fleck, Florian Paul Christian Binder, Georg Dahmann, Joerg P. Hehn, Annekatrin Charlotte Heimann, Uta Friederike Lessel, Jens Willwacher
  • IMIDAZO[4,5-D]PYRIDAZINONYL DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20220340580
    Abstract: The present disclosure provides certain imidazo[4,5-d]pyridazinonyl derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 27, 2022
    Inventors: Florian Paul Christian BINDER, Georg DAHMANN, Martin Thomas FLECK, Annekatrin Charlotte HEIMANN, Thorsten OOST
  • 3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20220340593
    Abstract: The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5-b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 27, 2022
    Inventors: Martin Thomas FLECK, Florian Paul Christian BINDER
  • 3H,4H-THIENO[2,3-D]PYRIMIDIN-4-ONE DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20220340590
    Abstract: The present disclosure provides certain 3H,4H-thieno[2,3-d]pyrimidin-4-one derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 27, 2022
    Inventors: Florian Paul Christian BINDER, Jens WILLWACHER, Martin Thomas FLECK
  • URACIL DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20220340552
    Abstract: The present disclosure provides certain uracil derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 27, 2022
    Inventors: Florian Paul Christian BINDER, Martin Thomas FLECK, Jens WILLWACHER
  • Fastening for a vehicle part to a vehicle body of a motor vehicle
    Patent number: 11332065
    Abstract: A motor vehicle has a body, a vehicle part, and a spring bolt for fastening the vehicle part in a receptacle of the body. The rotational axis of the spring bolt is arranged in such a way that it has exactly one point of intersection with an XY plane of the motor vehicle.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: May 17, 2022
    Assignee: Bayerische Motoren Werke Aktiengesellschaft
    Inventors: Nicholas Aldersley, Thomas Fleck, Matthias Ruppert
  • TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20220112202
    Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: October 13, 2021
    Publication date: April 14, 2022
    Inventors: Martin Thomas FLECK, Florian Paul Christian BINDER, Jens WILLWACHER
  • HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS
    Publication number: 20220048885
    Abstract: The present invention encompasses compounds of the formula I which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
    Type: Application
    Filed: June 25, 2021
    Publication date: February 17, 2022
    Inventors: Martin Thomas FLECK, Cedrickx GODBOUT, Hannes Fiepko KOOLMAN
  • HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS
    Publication number: 20220048889
    Abstract: The present invention encompasses compounds of the formula I which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
    Type: Application
    Filed: December 2, 2019
    Publication date: February 17, 2022
    Inventors: Cedrickx GODBOUT, Martin Thomas FLECK, Hannes Fiepko KOOLMAN, Thomas Martin KIRRANE, Jr.
  • HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS
    Publication number: 20220041592
    Abstract: The present invention encompasses compounds of the formula I which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
    Type: Application
    Filed: December 2, 2019
    Publication date: February 10, 2022
    Inventors: Cedrickx GODBOUT, Martin Thomas FLECK, Hannes Fiepko KOOLMAN
  • TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20220002270
    Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: June 24, 2021
    Publication date: January 6, 2022
    Inventors: Florian Paul Christian BINDER, Martin Thomas FLECK, Jens WILLWACHER
  • TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20210403482
    Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: June 24, 2021
    Publication date: December 30, 2021
    Inventors: Martin Thomas FLECK, Florian Paul Christian BINDER, Jens WILLWACHER