Patents by Inventor Thomas Force

Thomas Force has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid molecule encoding Ste20 oxidant stress response kinase-1 (SOK-1) polypeptide
    Patent number: 6093560
    Abstract: A SOK polypeptide, an isolated DNA having a nucleotide sequence encoding a SOK polypeptide, and a method of determining whether a candidate compound modulates SOK-1 activity or expression, comprising the steps of providing a first and a second recombinant cell expressing a SOK gene; introducing a candidate compound into the first cell, but not into the second cell; measuring a SOK function in the first and second cells; and comparing the results obtained with the first and second SOK transformed cells, wherein an increase or decrease in the SOK function in the first cell compared to the second cell is an indication that the candidate compound modulates SOK expression or activity.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: July 25, 2000
    Assignee: The General Hospital Corporation
    Inventors: Thomas Force, John M. Kyriakis, Celia M. Pombo, Joseph Bonventre
  • SOK-1 and methods of use
    Patent number: 5830699
    Abstract: A SOK polypeptide, an isolated DNA having a nucleotide sequence encoding a SOK polypeptide, and a method of determining whether a candidate compound modulates SOK-1 activity or expression, comprising the steps of providing a first and a second recombinant cell expressing a SOK gene; introducing a candidate compound into the first cell, but not into the second cell; measuring a SOK function in the first and second cells; and comparing the results obtained with the first and second SOK transformed cells, wherein an increase or decrease in the SOK function in the first cell compared to the second cell is an indication that the candidate compound modulates SOK expression or activity.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: November 3, 1998
    Assignee: The General Hospital Corporation
    Inventors: Thomas Force, John M. Kyriakis, Celia M. Pombo, Joseph Bonventre