Abstract: The present disclosure relates to treating a disease in a subject in need thereof comprising administrating a pharmaceutically active ingredient present in a pseudo-ternary phase system.

Abstract: The present disclosure relates to a pseudo-ternary phase system for improving solubility of a pharmaceutically active ingredient.

Abstract: The present disclosure relates to forming a self-microemulsifying drug delivery system.

Abstract: The present disclosure relates to generating a microemulsion formation with improved solubility.

Abstract: A visual perception device is described. The visual perception device has corrective optics for viewing virtual and real-world content. An insert for the corrective optics is attached using a magnetic set, pins and/or a nose piece. Interchangeable nose pieces allow for height adjustments to accommodate different users. The visual perception device has pliable components to absorb forces exerted on a nose piece and a protective barrier for limiting electric shock or ingress of dirt.

Abstract: A visual perception device is described. The visual perception device has corrective optics for viewing virtual and real-world content. An insert for the corrective optics is attached using a magnetic set, pins and/or a nose piece. Interchangeable nose pieces allow for height adjustments to accommodate different users. The visual perception device has pliable components to absorb forces exerted on a nose piece and a protective barrier for limiting electric shock or ingress of dirt.

Abstract: A head mounted device padding system includes a pad having an interior side and an exterior side. The interior side of the pad has a substantially concave first curvature about a first axis of the pad, and a substantially convex second curvature about a second axis of the pad.

Abstract: A blade includes an airfoil defined by a pressure side outer wall and a suction side outer wall connecting along leading and trailing edges and form a radially extending chamber for receiving a coolant flow. A rib configuration may include: a leading edge transverse rib connecting the pressure side outer wall and the suction side outer wall and partitioning the radially extending chamber into a leading edge passage within the leading edge of the airfoil and a central passage adjacent to the leading edge passage. One or both camber line ribs connect to a corresponding pressure side outer wall and suction side outer wall at a point aft of the leading edge transverse rib causing the central passage to extend towards one or both of the pressure side outer wall and the suction side outer wall, resulting in a flared center cavity aft of the leading edge.

Abstract: A hot gas path component assembly includes a first component portion that includes a first set of interlocking features and a second component portion that includes a second set of interlocking features mechanically coupled to the first set of interlocking features. A fill material is disposed at an interface between at least one surface of the first set of interlocking features and at least one surface of the second set of interlocking features. The fill material is disposed during a joining process. The second component portion is joined to the first component portion via both the fill material and the first and second sets of interlocking features.

Abstract: A prepackaged injectable pharmaceutical composition includes a sealed outer package made of a material having a low oxygen transmission rate and an inner package disposed within the sealed outer package. The inner package is configured to provide an indication that the inner package has been opened after being closed. A prefilled syringe is disposed within the inner package. The syringe includes a barrel comprising a polymeric material and a dose of the injectable pharmaceutical composition.

Abstract: A blade includes an airfoil defined by a pressure side outer wall and a suction side outer wall connecting along leading and trailing edges and form a radially extending chamber for receiving a coolant flow. A rib configuration may include: a leading edge transverse rib connecting the pressure side outer wall and the suction side outer wall and partitioning the radially extending chamber into a leading edge passage within the leading edge of the airfoil and a central passage adjacent to the leading edge passage. One or both camber line ribs connect to a corresponding pressure side outer wall and suction side outer wall at a point aft of the leading edge transverse rib causing the central passage to extend towards one or both of the pressure side outer wall and the suction side outer wall, resulting in a flared center cavity aft of the leading edge.

Abstract: A visual perception device is described. The visual perception device has corrective optics for viewing virtual and real-world content. An insert for the corrective optics is attached using a magnetic set, pins and/or a nose piece. Interchangeable nose pieces allow for height adjustments to accommodate different users. The visual perception device has pliable components to absorb forces exerted on a nose piece and a protective barrier for limiting electric shock or ingress of dirt.

Abstract: A blade includes an airfoil defined by a pressure side outer wall and a suction side outer wall connecting along leading and trailing edges and form a radially extending chamber for receiving a coolant flow. A rib configuration may include: a leading edge transverse rib connecting the pressure side outer wall and the suction side outer wall and partitioning the radially extending chamber into a leading edge passage within the leading edge of the airfoil and a central passage adjacent to the leading edge passage. One or both camber line ribs connect to a corresponding pressure side outer wall and suction side outer wall at a point aft of the leading edge transverse rib causing the central passage to extend towards one or both of the pressure side outer wall and the suction side outer wall, resulting in a flared center cavity aft of the leading edge.

Abstract: A visual perception device is described. The visual perception device has corrective optics for viewing virtual and real-world content. An insert for the corrective optics is attached using a magnetic set, pins and/or a nose piece. Interchangeable nose pieces allow for height adjustments to accommodate different users. The visual perception device has pliable components to absorb forces exerted on a nose piece and a protective barrier for limiting electric shock or ingress of dirt.

Abstract: A hot gas path component assembly includes a first component portion that includes a first set of interlocking features and a second component portion that includes a second set of interlocking features mechanically coupled to the first set of interlocking features. A fill material is disposed at an interface between at least one surface of the first set of interlocking features and at least one surface of the second set of interlocking features. The fill material is disposed during a joining process. The second component portion is joined to the first component portion via both the fill material and the first and second sets of interlocking features.

Abstract: A head mounted device padding system includes a pad having an interior side and an exterior side. The interior side of the pad has a substantially concave first curvature about a first axis of the pad, and a substantially convex second curvature about a second axis of the pad.

Abstract: A turbine airfoil includes a leading edge, a trailing edge, a pressure side wall extending between the leading edge and the trailing edge, a suction side wall extending between the leading edge and the trailing edge, a cooling air supply cavity disposed within the turbine airfoil, and a near wall cooling cavity disposed within the turbine airfoil and fluidly coupled to the cooling air supply cavity to receive cooling air. In addition, the near wall cooling cavity partially extends along the suction side wall from adjacent the leading edge to a location more proximal the trailing edge. Moreover, the near wall cooling cavity provides near wall cooling to a high heat load region along the suction side wall.

Abstract: A cooling system according to an embodiment includes: a leading edge cooling circuit including a pressure side serpentine circuit and a suction side serpentine circuit; a first mid-blade cooling circuit including a suction side serpentine circuit; a second mid-blade cooling circuit including a pressure side serpentine circuit; a trailing edge cooling circuit; and at least one air feed for supplying cooling air to the leading edge cooling circuit, the first mid-blade cooling circuit, the second mid-blade cooling circuit, and the trailing edge cooling circuit.

Abstract: The present disclosure relates to pharmaceutical compositions comprising CRV431 or a pharmaceutically acceptable salt thereof. The compositions exhibit high solubility and stability.

Abstract: One aspect of the disclosure provides for a turbine airfoil. The turbine airfoil may include a trailing edge having: a set of cooling channels having a first cooling channel fluidly connected to a second cooling channel; a first section having a first pin bank cooling arrangement, the first section fluidly connected to the first cooling channel; a second section having a second pin bank cooling arrangement, the second section fluidly connected to the second cooling channel and being radially inward of the first section; and a pressure side panel having a third pin bank cooling arrangement, the pressure side panel fluidly connected to the first cooling channel.