Patents by Inventor Thomas Franch

Thomas Franch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds active towards nuclear receptors
    Patent number: 11780843
    Abstract: Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: October 10, 2023
    Assignee: NUEVOLUTION A/S
    Inventors: Sanne Schrøder Glad, Ian Sarvary, Alex Haahr Gouliaev, Thomas Franch, Luigi Piero Stasi, Montserrat Erra Solà, Joan Taltavull Moll, Paul Robert Eastwood
  • COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS
    Publication number: 20230271937
    Abstract: Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
    Type: Application
    Filed: May 5, 2023
    Publication date: August 31, 2023
    Inventors: Sanne Schrøder Glad, Ian Sarvary, Alex Haahr Gouliaev, Thomas Franch, Søren Jensby Nielsen, Luigi Piero Stasi, Montserrat Erra Solà, Lorena Taboada Martínez, Joan Taltavull Moll, Juan Francisco Caturla Javaloyes, Lluís Miquel Pagès Santacana
  • Enzymatic encoding methods for efficient synthesis of large libraries
    Patent number: 11702652
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: July 18, 2023
    Assignee: NUEVOLUTION A/S
    Inventors: Thomas Franch, Mikkel Dybro Lundorf, Søren Nyboe Jakobsen, Eva Kampmann Olsen, Anne Lee Andersen, Anette Holtmann, Anders Holm Hansen, Anders Malling Sørensen, Anne Goldbech, Daen de Leon, Ditte Kievsmose Kaldor, Frank Abildgaard Sløk, Gitte Nystrup Husemoen, Johannes Dolberg, Kim Birkebæk Jensen, Lene Petersen, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Søren Neve, Thomas Thisted, Tine Titilola Akinleminu Kronborg, Christian Klarner Sams, Jakob Felding, Per-Ola Freskgard, Alex Haahr Gouliaev, Henrik Pedersen
  • Compounds active towards nuclear receptors
    Patent number: 11685727
    Abstract: Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: June 27, 2023
    Assignee: NUEVOLUTION A/S
    Inventors: Sanne Schrøder Glad, Ian Sarvary, Alex Haahr Gouliaev, Thomas Franch, Søren Jensby Nielsen, Luigi Piero Stasi, Montserrat Erra Solà, Lorena Taboada Martínez, Joan Taltavull Moll, Juan Francisco Caturla Javaloyes, Lluís Miquel Pagès Santacana
  • COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS
    Publication number: 20220363683
    Abstract: Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
    Type: Application
    Filed: March 31, 2021
    Publication date: November 17, 2022
    Inventors: Sanne Schrøder Glad, Ian Sarvary, Alex Haahr Gouliaev, Thomas Franch, Luigi Piero Stasi, Montserrat Erra Solà, Joan Taltavull Moll, Paul Robert Eastwood
  • BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
    Publication number: 20220340893
    Abstract: The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
    Type: Application
    Filed: December 3, 2021
    Publication date: October 27, 2022
    Applicant: Nuevolution A/S
    Inventors: Alex Haahr GOULIAEV, Thomas FRANCH, Michael Anders GODSKESEN, Kim Birkebæk JENSEN
  • Compounds active towards nuclear receptors
    Patent number: 11447479
    Abstract: Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: September 20, 2022
    Assignee: NUEVOLUTION A/S
    Inventors: Sanne Schrøder Glad, Ian Sarvary, Alex Haahr Gouliaev, Thomas Franch, Søren Jensby Nielsen, Luigi Piero Stasi
  • Bi-functional complexes and methods for making and using such complexes
    Patent number: 11225655
    Abstract: The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
    Type: Grant
    Filed: April 16, 2011
    Date of Patent: January 18, 2022
    Assignee: NUEVOLUTION A/S
    Inventors: Alex Haahr Gouliaev, Thomas Franch, Michael Anders Godskesen, Kim Birkebæk Jensen
  • COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS
    Publication number: 20210188828
    Abstract: Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 24, 2021
    Inventors: Sanne Schrøder Glad, Ian Sarvary, Alex Haahr Gouliaev, Thomas Franch, Søren Jensby Nielsen, Luigi Piero Stasi
  • COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS
    Publication number: 20210188807
    Abstract: Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 24, 2021
    Inventors: Sanne Schrøder Glad, Ian Sarvary, Alex Haahr Gouliaev, Thomas Franch, Søren Jensby Nielsen, Luigi Piero Stasi, Montserrat Erra Solà, Lorena Taboada Martínez, Joan Taltavull Moll, Juan Francisco Caturla Javaloyes, Lluís Miquel Pagès Santacana
  • Method for the synthesis of a bifunctional complex
    Patent number: 11001835
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: May 11, 2021
    Assignee: Nuevolution A/S
    Inventors: Per-Ola Freskgard, Thomas Franch, Alex Haahr Gouliaev, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Schroeder Glad, Kim Birkebaek Jensen, Henrik Pedersen
  • Method for synthesising templated molecules
    Patent number: 10731151
    Abstract: The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: August 4, 2020
    Assignee: NUEVOLUTION A/S
    Inventors: Henrik Pedersen, Anette Holtmann, Thomas Franch, Alex Haahr Gouliaev, Jakob Felding
  • ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
    Publication number: 20200216836
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Application
    Filed: January 15, 2020
    Publication date: July 9, 2020
    Applicant: NUEVOLUTION A/S
    Inventors: Thomas FRANCH, Mikkel Dybro LUNDORF, Søren Nyboe JAKOBSEN, Eva Kampmann OLSEN, Anne Lee ANDERSEN, Anette HOLTMANN, Anders Holm HANSEN, Anders Malling SØRENSEN, Anne GOLDBECH, Daen de LEON, Ditte Kievsmose KALDOR, Frank Abildgaard SLØK, Gitte Nystrup HUSEMOEN, Johannes DOLBERG, Kim Birkebæk JENSEN, Lene PETERSEN, Mads NØRREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schrøder GLAD, Søren NEVE, Thomas THISTED, Tine Titilola Akinleminu KRONBORG, Christian Klarner SAMS, Jakob FELDING, Per-Ola FRESKGARD, Alex Haahr GOULIAEV, Henrik PEDERSEN
  • Templated molecules and methods for using such molecules
    Patent number: 10669538
    Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The invention allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: June 2, 2020
    Assignee: NUEVOLUTION A/S
    Inventors: Henrik Pedersen, Alex Haahr Gouliaev, Thomas Franch, Christian Klarner Sams, Eva Kampmann Olsen, Frank Abilgaard Slok, Gitte Nystrup Husemoen, Jakob Felding, Lene Hyldtoft, Mads Norregaard-Madsen, Michael Anders Godskesen, Sanne Schroder Glad, Thomas Thisted, Per-Ola Freskgard, Anette Holtmann
  • ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
    Publication number: 20190330618
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Application
    Filed: January 22, 2019
    Publication date: October 31, 2019
    Inventors: Thomas FRANCH, Mikkel Dybro LUNDORF, Søren Nyboe JAKOBSEN, Eva Kampmann OLSEN, Anne Lee ANDERSEN, Anette HOLTMANN, Anders Holm HANSEN, Anders Malling SØRENSEN, Anne GOLDBECH, Daen de LEON, Ditte Kievsmose KALDOR, Frank Abildgaard SLØK, Gitte Nystrup HUSEMOEN, Johannes DOLBERG, Kim Birkebæk JENSEN, Lene PETERSEN, Mads NØRREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schrøder GLAD, Søren NEVE, Thomas THISTED, Tine Titilola Akinleminu KRONBORG, Christian Klarner SAMS, Jakob FELDING, Per-Ola FRESKGARD, Alex GOULIAEV, Henrik PEDERSEN
  • Enzymatic encoding methods for efficient synthesis of large libraries
    Patent number: 10287576
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: May 14, 2019
    Assignee: NUEVOLUTION A/S
    Inventors: Thomas Franch, Mikkel Dybro Lundorf, Søren Nyboe Jakobsen, Eva Kampmann Olsen, Anne Lee Andersen, Anette Holtmann, Anders Holm Hansen, Anders Malling Sørensen, Anne Goldbech, Daen de Leon, Ditte Kievsmose Kaldor, Frank Abildgaard Sløk, Gitte Nystrup Husemoen, Johannes Dolberg, Kim Birkebæk Jensen, Lene Petersen, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Søren Neve, Thomas Thisted, Tine Titilola Akinleminu Kronborg, Christian Klarner Sams, Jakob Felding, Per-Ola Freskgard, Alex Haahr Gouliaev, Henrik Pedersen
  • METHOD FOR THE SYNTHESIS OF A BIFUNCTIONAL COMPLEX
    Publication number: 20190136227
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Application
    Filed: August 7, 2018
    Publication date: May 9, 2019
    Inventors: Per-Ola FRESKGARD, Thomas FRANCH, Alex Haahr GOULIAEV, Mikkel Dybro LUNDORF, Jakob FELDING, Eva Kampmann OLSEN, Anette HOLTMANN, Soeren Nyboe JAKOBSEN, Christian Klarner SAMS, Sanne Schroeder GLAD, Kim Birkebaek JENSEN, Henrik PEDERSEN
  • Method for the synthesis of a bifunctional complex
    Patent number: 10077440
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: September 18, 2018
    Assignee: Nuevolution A/S
    Inventors: Per-Ola Freskgard, Thomas Franch, Alex Haahr Gouliaev, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Schroeder Glad, Kim Birkebaek Jensen, Henrik Pedersen
  • Method for the synthesis of a bifunctional complex
    Patent number: 9885035
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: February 6, 2018
    Assignee: Nuevolution A/S
    Inventors: Thomas Franch, Alex Haahr Gouliaev
  • ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
    Publication number: 20170247688
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Application
    Filed: December 12, 2016
    Publication date: August 31, 2017
    Applicant: NUEVOLUTION A/S
    Inventors: Thomas FRANCH, Mikkel Dybro LUNDORF, Søren Nyboe JACOBSEN, Eva Kampmann OLSEN, Anne Lee ANDERSEN, Anette HOLTMANN, Anders Holm HANSEN, Anders Malling SØRENSEN, Anne GOLDBECH, Daen de LEON, Ditte Kievsmose KALDOR, Frank Abildgaard SLØK, Gitte Nystrup HUSEMOEN, Johannes DOLBERG, Kim Birkebæk JENSEN, Lene PEDERSEN, Mads NØRREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schrøder GLAD, Søren NEVE, Thomas THISTED, Tine Titilola Akinleminu KRONBORG, Christian Klarner SAMS, Jakob FELDING, Per-Ola FRESKGARD, Alex Haahr GOULIAEV, Henrik PEDERSEN