Patents by Inventor Thomas Francis
Thomas Francis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250092036Abstract: The invention relates to compounds which modulate the activity of ERK. The present invention also relates to processes for the preparation of said compounds, pharmaceutical compositions comprising said compounds, and use of said compounds in the treatment of conditions, diseases and disorders mediated by ERK.Type: ApplicationFiled: August 12, 2024Publication date: March 20, 2025Inventors: Erich W. BAUM, Thomas A. DINEEN, JR., Jonathan Edward HEMPEL, Matthew James HESSE, Robert KOENIG, Matthew James LAMARCHE, Jay Francis LARROW, Ruowei MO, Henrik MOEBITZ, Rukundo NTAGANDA, Keith Bruce PFISTER, Martin SENDZIK, Colin Keith SKEPPER, Joseph WZOREK, JR., Frédéric ZECRI
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Patent number: 12246131Abstract: A patient interface includes a frame assembly including connectors operatively attachable to headgear, a cushion assembly provided to the frame assembly and including a seal-forming structure structured to form a seal with the patient's nose and/or mouth, and an air delivery connector provided to the frame assembly and operatively connected to an air delivery tube for supplying the air at positive pressure along an air flow path. The cushion assembly is structured to releasably connect to the frame assembly independently of the air delivery connector. The air delivery connector is structured to releasably connect to the frame assembly independently of the cushion assembly.Type: GrantFiled: November 23, 2021Date of Patent: March 11, 2025Assignee: RESMED PTY LTDInventors: Amal Shirley Amarasinghe, Ravikumar Baluchagi, Adam Francis Barlow, Andrew James Bate, Emily Elizabeth Blanch, David James Braund, Christopher Samuel Cullen, Errol Savio Alex D'Souza, Bruce Richard Davies, Craig David Edwards, Christopher Andrew Wakeley Gill, Lachlan Richard Goldspink, Thomas Kirby, Kishore Markapuram Chengalvarayan, Holly Elizabeth Miller, Lemmy Nga, Chia Ik Tan, Matthew Robin Wells
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Publication number: 20250058514Abstract: A three-dimensional structure is formed when layers of a material are deposited onto a substrate and scanned with a high energy beam to at least partially melt each layer of the material. Upon scanning the layers at predetermined locations at least a first segment overlapping a second segment and underlapping a third segment is formed.Type: ApplicationFiled: August 23, 2024Publication date: February 20, 2025Inventors: Thomas Francis McCarthy, Brock Miller, Robin Stamp, Yuri Zaitsev, Robert W. Klein, Marc Esformes, David Markel, Amit Mistry, Joseph Robinson
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Publication number: 20250058066Abstract: A PAP system includes a PAP device to generate a supply of pressurized air, a patient interface adapted to form a seal with the patient's face, air delivery tubing to interconnect the patient interface and the PAP device, and a cover that substantially encloses at least a portion of the PAP device and a portion of the air delivery tubing. The cover allows the PAP device to be carried by and/or supported on the patient's head.Type: ApplicationFiled: November 7, 2024Publication date: February 20, 2025Inventors: Adam Francis Barlow, Michael Stephen Cheung, Thomas M. Dair, Aaron Samuel Davidson, Justin John Formica, Samuel Aziz Mebasser, Michael Murillo, Andrew Martin Price, Jose Ignacio Romagnoli, Gerard Michael Rummery, Allan Freas Velzy
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Publication number: 20250055450Abstract: This disclosure relates to a bootstrapped switching circuit. Example embodiments include a bootstrapped switching circuit (100) comprising: a positive output node (109+); a negative output node (109?); a first input node (106a) configured to receive a first input voltage (Vin1); a second input node (106b) configured to receive a second input voltage (Vin2). First, second third and fourth switches (101-104) are coupled between the input and output nodes (106a, 106b, 109+, 109?). A first negative bootstrapped level shifter (107a) and a first positive bootstrapped level shifter (107b) coupled between the first input node (106a) and a first clock signal circuit (110a) provide control signals to the first and second switches (101, 102). A second negative bootstrapped level shifter (108a) and a second positive bootstrapped level shifter (108b) coupled between the second input node (106b) and a second ground referenced supply line (110b) provide control signals to the third and fourth switches (103, 104).Type: ApplicationFiled: August 2, 2024Publication date: February 13, 2025Inventors: Pascal Sandrez, Thomas Mallard, An Vu Thuy Hoang, Matthew Francis Bacchi, Thierry Dominique Yves Cassagnes
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Patent number: 12220567Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.Type: GrantFiled: January 16, 2024Date of Patent: February 11, 2025Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
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Patent number: 12220321Abstract: Disclosed herein is an implant. The implant can include a body and a plurality of fixation members. The body can define an articular surface and a bone engaging surface opposite the articular surface. The bone engaging surface can define a groove that separates a first section of the bone engaging surface from a second section of the bone engaging surface. The plurality of fixation members can extend from the bone engaging surface.Type: GrantFiled: October 28, 2022Date of Patent: February 11, 2025Assignee: Biomet Manufacturing, LLCInventors: Clinton E. Kehres, Michael Francis Kovacs, Thomas Michael Vanasse
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Patent number: 12220563Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.Type: GrantFiled: March 20, 2024Date of Patent: February 11, 2025Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
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Patent number: 12220564Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.Type: GrantFiled: June 26, 2024Date of Patent: February 11, 2025Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
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Patent number: 12214171Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.Type: GrantFiled: June 27, 2024Date of Patent: February 4, 2025Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
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Patent number: 12214170Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.Type: GrantFiled: June 26, 2024Date of Patent: February 4, 2025Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
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Patent number: 12214176Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.Type: GrantFiled: June 27, 2024Date of Patent: February 4, 2025Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
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Patent number: 12214172Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.Type: GrantFiled: June 27, 2024Date of Patent: February 4, 2025Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
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Patent number: 12208247Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.Type: GrantFiled: March 20, 2024Date of Patent: January 28, 2025Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
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Patent number: 12208248Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.Type: GrantFiled: March 20, 2024Date of Patent: January 28, 2025Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
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Patent number: 12204855Abstract: A document is obtained that include natural language text and a set of conditions are extracted from the document. In at least one embodiment, the set of conditions is extracted using a machine learning model trained on other natural language text. A validation process is performed to result in a validated set of conditions and a machine-readable data structure is generated to indicate one or more conditions of the validated set of conditions expressed within the document.Type: GrantFiled: September 3, 2024Date of Patent: January 21, 2025Assignee: Citigroup Inc.Inventors: Ernst Wilhem Spannhake, II, Gayathri Venkat, Hiten Jayantilal Shah, Thomas Francis Gianelle
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Patent number: 12195547Abstract: The present invention relates to the treatment of subjects having CD20-positive cell proliferative disorders (e.g., B cell proliferative disorders, such as non-Hodgkin's lymphomas). More specifically, the invention pertains to the treatment of subjects having a CD20-positive cell proliferative disorder (e.g., B cell proliferative disorder) by administering a combination of an anti-CD20/anti-CD3 bispecific antibody and an anti-CD79b antibody drug conjugate.Type: GrantFiled: April 29, 2022Date of Patent: January 14, 2025Assignee: Hoffmann-La Roche Inc.Inventors: Katharina Lechner, Thomas Francis Moore, Martin Weisser, Natalie Dimier, David John Carlile, Nassim Djebli, Peter Nabil Morcos, Linda Maria Lundberg
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Publication number: 20250005516Abstract: A customer application renders a customer graphical user interface including a plurality of items for sale at a store and generates a customer order in response to input received from the customer. The customer order includes a plurality of ordered items for picking in the store. The customer application is configured to generate an order modification interface configured to receive at least one of addition modifications, deletion modifications, and substitution modifications. A computing system is configured to determine whether the customer order is eligible to be modified by the customer based on satisfaction of one or more modification eligibility conditions and send an eligibility determination to the customer device that indicates whether the customer order is eligible to be modified. The customer application is configured to receive customer input in the order modification interface that modifies the customer order when the customer order is eligible to be modified.Type: ApplicationFiled: June 27, 2024Publication date: January 2, 2025Inventor: Thomas Francis
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Publication number: 20240428050Abstract: The systems and methods may use one or more artificial intelligence models that predict an effect of a predicted event on a current state of the system. For example, the model may predict how a rate of change in time-series data may be altered throughout the first time period based on the predicted event. However, as noted above, correctly predicting the occurrence of outlier events (e.g., the predicted event), and in particular characteristics about the outlier events (e.g., when an outlier may occur, what may be a source of the outlier, what rate of change the outlier may cause, etc.), in data-sparse environments and based on time-series data presents a technical challenge.Type: ApplicationFiled: September 5, 2024Publication date: December 26, 2024Applicant: Citibank, N.A.Inventors: Prasanth Babu MADAKASIRA RAMAKRISHNA, Girish WALI, Deepali TUTEJA, Ernst Wilhelm SPANNHAKE, II, Thomas Francis GIANELLE, Milan SHAH
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Publication number: 20240411766Abstract: Systems and methods are described herein for novel uses and/or improvements to data aggregation related to artificial intelligence applications, specifically applications related to aggregating time-series data. As one example, systems and methods are described herein for predicting effects when aggregating time-series data and modifying the one or more data streams used to populate a model profile and/or feed an artificial intelligence application with the time-series data.Type: ApplicationFiled: August 20, 2024Publication date: December 12, 2024Applicant: Citibank, N.A.Inventors: Ernst Wilhelm Spannhake, II, Thomas Francis Gianelle, Milan Shah