Patents by Inventor Thomas G. Archibald

Thomas G. Archibald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8835684
    Abstract: The present invention provides a new process for the preparation of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2R,3S-derivative, but also the 2S,3S-, 2S,2R- and the 2R,3R-derivatives.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: September 16, 2014
    Assignee: Ampac Fine Chemicals LLC
    Inventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, Robert G. Miotke
  • Publication number: 20100286444
    Abstract: The present invention provides a new process for the preparation of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2R,35-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2R,3S-derivative, but also the 2S,3S-, 2S,2R- and the 2R,3R-derivatives.
    Type: Application
    Filed: July 21, 2010
    Publication date: November 11, 2010
    Applicant: Ampac Fine Chemicals LLC
    Inventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, Robert G. Miotke
  • Patent number: 7807850
    Abstract: The present invention provides a new process for the preparation of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbuty1)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2R,3S-derivative, but also the 2S,3S-, 2S,2R- and the 2R,3R-derivatives.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: October 5, 2010
    Assignee: Ampac Fine Chemicals LLC
    Inventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, Robert G. Miotke
  • Publication number: 20080312469
    Abstract: The present invention provides a new process for the preparation of 2S,3S—N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S—N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.
    Type: Application
    Filed: August 13, 2008
    Publication date: December 18, 2008
    Applicant: Ampac Fine Chemicals LLC
    Inventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, Robert G. Miotke
  • Patent number: 7414144
    Abstract: The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: August 19, 2008
    Assignee: Aerojet Fine Chemicals LLC
    Inventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, Robert G. Miotke
  • Patent number: 7354985
    Abstract: This application is directed to novel fluorinated polymers and prepolymers derived from mono-substituted oxetane monomers having fluorinated alkoxymethylene side-chains and the method of making these compositions. The mono-substituted fluorinated oxetane monomers having fluorinated alkoxymethylene side-chains are prepared in high yield by the reaction of a fluorinated alkoxides with either 3-halomethyl-3-methyloxetane premonomers or aryl sulfonate derivative of 3-hydroxymethyl-3-methyloxetane premonomers. Preparation of a mono-substituted 3-bromomethyl-3-methyloxetane premonomer via a simple, high yield process amenable to commercial scaleup is also disclosed. The fluorinated oxetane monomers of this invention can be readily homo/co-polymerized in the presence of a Lewis acid and polyhydroxy compounds to obtain hydroxy-terminated polyether prepolymers having fluorinated alkoxymethylene side chains.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: April 8, 2008
    Inventors: Aslam A. Malik, Thomas G. Archibald
  • Patent number: 7148309
    Abstract: This invention is directed to mono- and bis-substituted oxetane monomers having fluorinated alkoxymethylene side chains, hydroxy-terminated prepolymers derived from these mono- and bis-substituted oxetane monomers and tetrahydrofuran (THF), and polymers produced from these prepolymers, as well as the synthesis processes associated with each, and the use of the monomers, prepolymers and ultimate polymers, both directly and as components of numerous compositions.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: December 12, 2006
    Assignee: AMPAC Fine Chemicals LLC
    Inventors: Aslam A. Malik, Thomas G. Archibald, Roland P. Carlson, Kenneth J. Wynne, Edward N. Kresge
  • Patent number: 6998460
    Abstract: This invention is directed to mono- and bis-substituted oxetane monomers having fluorinated alkoxymethylene side chains, hydroxy-terminated prepolymers derived from these mono- and bis-substituted oxetane monomers and tetrahydrofuran (THF), and polymers produced from these prepolymers, as well as the synthesis processes associated with each, and the use of the monomers, prepolymers and ultimate polymers, both directly and as components of numerous compositions.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: February 14, 2006
    Assignees: Aerojet-General Corporation, Omnova Solutions Inc.
    Inventors: Aslam A. Malik, Thomas G. Archibald, Roland P. Carlson, Kenneth J. Wynne, Edward N. Kresge
  • Patent number: 6891013
    Abstract: The present invention provides, inter alia, novel fluorinated polyurethane elastomers (e.g., fluorinated thermoset polyurethane elastomers and fluorinated thermoplastic elastomers) prepared from polyether prepolymers formed from mono-substituted fluorinated oxetane monomers (FOX monomers) and tetrahydrofuran (THF). In addition, the present invention provides methods of making such fluorinated polyurethane elastomers.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: May 10, 2005
    Assignee: Aerojet-General Corporation
    Inventors: Aslam A. Malik, Thomas G. Archibald
  • Patent number: 6852887
    Abstract: The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: February 8, 2005
    Assignee: Aerojet Fine Chemicals LLC
    Inventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, Robert G. Miotke
  • Patent number: 6825316
    Abstract: This invention is directed to mono- and bis-substituted oxetane monomers having fluorinated alkoxymethylene side chains, hydroxy-terminated prepolymers derived from these mono- and bis-substituted oxetane monomers and tetrahydrofuran (THF), and polymers produced from these prepolymers, as well as the synthesis processes associated with each, and the use of the monomers, prepolymers and ultimate polymers, both directly and as components of numerous compositions.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: November 30, 2004
    Assignees: Aerojet-General Corporation, Omnova Solutions, Inc.
    Inventors: Aslam A. Malik, Thomas G. Archibald, Roland P. Carlson, Kenneth J. Wynne, Edward N. Kresge
  • Publication number: 20040087759
    Abstract: This application is directed to novel fluorinated polymers and prepolymers derived from mono-substituted oxetane monomers having fluorinated alkoxymethylene side-chains and the method of making these compositions. The mono-substituted fluorinated oxetane monomers having fluorinated alkoxymethylene side-chains are prepared in high yield by the reaction of a fluorinated alkoxides with either 3-halomethyl-3-methyloxetane premonomers or aryl sulfonate derivative of 3-hydroxymethyl-3-methyloxetane premonomers. Preparation of a mono-substituted 3-bromomethyl-3-methyloxetane premonomer via a simple, high yield process amenable to commercial scaleup is also disclosed. The fluorinated oxetane monomers of this invention can be readily homo/co-polymerized in the presence of a Lewis acid and polyhydroxy compounds to obtain hydroxy-terminated polyether prepolymers having fluorinated alkoxymethylene side chains.
    Type: Application
    Filed: October 3, 2003
    Publication date: May 6, 2004
    Inventors: Aslam A. Malik, Thomas G. Archibald
  • Publication number: 20030181723
    Abstract: The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present inventin can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.
    Type: Application
    Filed: March 4, 2003
    Publication date: September 25, 2003
    Applicant: Aerojet Fine Chemicals LLC, a Delaware limited liability company
    Inventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, Robert G. Miotke
  • Publication number: 20030158373
    Abstract: This invention is directed to mono- and bis-substituted oxetane monomers having fluorinated alkoxymethylene side chains, hydroxy-terminated prepolymers derived from these mono- and bis-substituted oxetane monomers and tetrahydrofuran (THF), and polymers produced from these prepolymers, as well as the synthesis processes associated with each, and the use of the monomers, prepolymers and ultimate polymers, both directly and as components of numerous compositions.
    Type: Application
    Filed: November 8, 2002
    Publication date: August 21, 2003
    Applicant: Aerojet-General Corporation
    Inventors: Aslam A. Malik, Thomas G. Archibald, Roland P. Carlson, Kenneth J. Wynne, Edward N. Kresge
  • Patent number: 6548706
    Abstract: The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present inventin can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: April 15, 2003
    Assignee: Aerojet Fine Chemicals LLC
    Inventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, Robert G. Miotke
  • Patent number: 6479623
    Abstract: This invention is directed to mono- and bis-substituted oxetane monomers having fluorinated alkoxymethylene side chains, hydroxy-terminated prepolymers derived from these mono- and bis-substituted oxetane monomers and tetrahydrofuran (THF), and polymers produced from these prepolymers, as well as the synthesis processes associated with each, and the use of the monomers, prepolymers and ultimate polymers, both directly and as components of numerous compositions.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: November 12, 2002
    Assignees: Omnova Solutions, Inc,, Aerojet-General Corporation
    Inventors: Aslam A. Malik, Thomas G. Archibald, Roland P. Carlson, Kenneth J. Wynne, Edward N. Kresge
  • Patent number: 6448368
    Abstract: The present invention provides, inter alia, novel fluorinated polymers and prepolymers derived from mono-substituted oxetane monomers having fluorinated alkoxymethylene side chains and methods of making such polymers and prepolymers.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: September 10, 2002
    Assignee: Aerojet-General Corporation
    Inventors: Aslam A. Malik, Thomas G. Archibald
  • Patent number: 6417373
    Abstract: New aza azetidinium sulfate compounds are described which can be intermediates in the preparation of azabicyclobutane.
    Type: Grant
    Filed: October 19, 1998
    Date of Patent: July 9, 2002
    Assignee: The United States of America as represented by Secretary of Army
    Inventors: Paritosh R. Dave, Thomas G. Archibald
  • Patent number: 6417314
    Abstract: The present invention provides, inter alia, novel fluorinated polyurethane elastomers (e.g., fluorinated thermoset polyurethane elastomers and fluorinated thermoplastic elastomers) prepared from polyether prepolymers formed from mono-substituted fluorinated oxetane monomers (FOX monomers). In addition, the present invention provides methods of making such fluorinated polyurethane elastomers.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: July 9, 2002
    Assignee: Aerojet-General Corporation
    Inventors: Aslam A. Malik, Thomas G. Archibald
  • Patent number: 6380351
    Abstract: The present invention provides, inter alia, novel fluorinated copolymers and coprepolymers derived from mono-substituted oxetane monomers having fluorinated alkoxymethylene side-chains (FOX monomers) and tetrahydrofuran (THF). In addition, the present invention provides methods of making such copolymers and coprepolymers.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: April 30, 2002
    Assignee: Aerojet-General Corporation
    Inventors: Aslam A. Malik, Thomas G. Archibald