Patents by Inventor Thomas G. Greene

Thomas G. Greene has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection and quantitation of 8-OH-adenine using monoclonal antibodies
    Patent number: 6900291
    Abstract: The present invention relates to methods and materials for the detection and quantitation 8-OH-Ade in biological specimens. Specifically, the present invention is directed to a group of highly specific monoclonal antibodies reactive with the modified nucleoside structure 8-OH-Ade, and to various immunoassays for 8-OH-Ade utilizing these monoclonal antibodies. The monoclonal antibodies of the present invention may be used in assays for diagnosing or monitoring the progression of certain types of cancer, in addition to a variety of other diseases associated with mutagenesis resulting from oxidative damage of DNA. Assays utilizing the monoclonal antibodies of the present invention may also be used to analyze or monitor toxicant exposure, such as from environmental sources. The monoclonal antibodies of the present invention were prepared with the immunogen 8-OH-adenosine coupled to keyhole limpet hemocyanin (KLH), not to 8-OH-Ade directly.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: May 31, 2005
    Assignee: CytoChem, Inc.
    Inventors: Eric H. Holmes, Thomas G. Greene
  • Detection and quantitation of 8-OH-adenine using monoclonal antibodies
    Publication number: 20030186344
    Abstract: The present invention relates to methods and materials for the detection and quantitation 8-OH-Ade in biological specimens. Specifically, the present invention is directed to a group of highly specific monoclonal antibodies reactive with the modified nucleoside structure 8-OH-Ade, and to various immunoassays for 8-OH-Ade utilizing these monoclonal antibodies. The monoclonal antibodies of the present invention may be used in assays for diagnosing or monitoring the progression of certain types of cancer, in addition to a variety of other diseases associated with mutagenesis resulting from oxidative damage of DNA. Assays utilizing the monoclonal antibodies of the present invention may also be used to analyze or monitor toxicant exposure, such as from environmental sources. The monoclonal antibodies of the present invention were prepared with the immunogen 8-OH-adenosine coupled to keyhole limpet hemocyanin (KLH), not to 8-OH-Ade directly.
    Type: Application
    Filed: February 25, 2003
    Publication date: October 2, 2003
    Applicant: CytoChem, Inc.
    Inventors: Eric H. Holmes, Thomas G. Greene
  • Detection and quantitation of 8-OH-Adenine using monoclonal antibodies
    Patent number: 6187551
    Abstract: The present invention relates generally to assays for 8-hydroxyadenine (8-OH-Ade) and, more particularly, to improved immunoassays for the detection and quantitation of 8-OH-Ade in biological specimens. The present invention further relates to new monoclonal antibodies directed against 8-OH-Ade for use in the immunoassays.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: February 13, 2001
    Assignee: CytoChem, Inc.
    Inventors: Eric H. Holmes, Thomas G. Greene