Abstract: A disposable and multiconfigurational animal habitat for obtaining physiological measurements of a small mammal is provided. The habitat includes a disposable and vertically oriented tower having a top, middle, and a bottom section. The tower includes a first chamber and a second chamber. The first chamber is sized, shaped, and configured to house the small mammal and is disposed in the top section of the tower. A first instrumentation platform is disposed in the first chamber and configured to support the small mammal. The second chamber is also sized, shaped, and configured to house the small mammal and disposed underneath the first instrumentation platform. A second instrumentation platform disposed in the second chamber and configured to support the small mammal. The habitat can be assembled from a kit comprising sheet of foldable disposable material having cut-outs and fold lines that can be folded to form the tower of the habitat.

Abstract: A disposable and multiconfigurational animal habitat for obtaining physiological measurements of a small mammal is provided. The habitat includes a disposable and vertically oriented tower having a top, middle, and a bottom section. The tower includes a first chamber and a second chamber. The first chamber is sized, shaped, and configured to house the small mammal and is disposed in the top section of the tower. A first instrumentation platform is disposed in the first chamber and configured to support the small mammal. The second chamber is also sized, shaped, and configured to house the small mammal and disposed underneath the first instrumentation platform. A second instrumentation platform disposed in the second chamber and configured to support the small mammal. The habitat can be assembled from a kit comprising sheet of foldable disposable material having cut-outs and fold lines that can be folded to form the tower of the habitat.

Abstract: An apparatus for non-invasively measuring an electrocardiogram (ECG) in a conscious ambulatory subject includes an electrically conductive platform. The electrically conductive platform establishes an electrical connection with the subject at one of a position forward (e.g., rostral to) or a position rearward (e.g., caudal to) the heart. An additional electrical connection is established at the other of a position forward (e.g., rostral to) or a position rearward (e.g., caudal to) on the subject. The position rearward to (e.g., caudal to) the heart can be the tail of the subject. The additional electrical connection can be established by a movable electrode, an electrically conductive ringlet, an additional electrically conductive platform, a region of conductive material, an electrically conductive dome, a food element, or one or more electrically conductive posts.

Abstract: An apparatus for non-invasively measuring an electrocardiogram (ECG) in a conscious ambulatory subject includes an electrically conductive platform. The electrically conductive platform establishes an electrical connection with the subject at one of a position forward (e.g., rostral to) or a position rearward (e.g., caudal to) the heart. An additional electrical connection is established at the other of a position forward (e.g., rostral to) or a position rearward (e.g., caudal to) on the subject. The position rearward to (e.g., caudal to) the heart can be the tail of the subject. The additional electrical connection can be established by a movable electrode, an electrically conductive ringlet, an additional electrically conductive platform, a region of conductive material, an electrically conductive dome, a food element, or one or more electrically conductive posts.

Abstract: The present invention provides methods of using halogenated volatile compounds, e.g., halogenated ether, for treating a neurological disorder, e.g., Parkinson's disease.

Abstract: The present invention provides methods of using halogenated volatile compounds, e.g., halogenated ether, for treating a neurological disorder, e.g., Parkinson's disease.

Abstract: A method and apparatus for enabling the non-invasive acquisition of physiological parameters of a mammal, while allowing the mammal to move around a predetermined area is provided. In accordance with one example embodiment, a monitoring device for non-invasively acquiring physiological measurements of a mammal is provided. The device includes a first electrode configured to attach to an ear of the mammal in a manner suitable for obtaining a first electrical signal. A second electrode is configured to attach to a first alternate location of the mammal in a manner suitable for obtaining a second electrical signal. A third electrode is configured to attach to a second alternate location of the mammal in a manner suitable for obtaining a third electrical signal. The first electrode, second electrode, and third electrode are in communication with a signal receiver. Physiological parameters, such as those associated with electrocardiograms, can be obtained using the monitoring device.

Abstract: A method and apparatus for recording and analyzing the gait of an animal is provided. The apparatus can take the form of a gait imaging system. The system includes a movable belt track upon which a subject can ambulate. An imaging device is disposed below the belt track to record contact between at least one limb of the subject and the belt track. The subject can ambulate along the belt track in a substantially stationary location above the imaging device as the belt track moves, and the imaging device can record the contact by the subject. A method of recording a gait of an ambulating subject is also provided. The method includes locating the subject on a movable belt track. The subject is motivated to ambulate along the movable belt track at about the same rate as the movable belt track, while the belt track is moving, such that the location of the subject does not substantially change.

Abstract: The mdx mouse is a model of Duchenne muscular dystrophy. The present invention describes that mdx mice exhibited clinically relevant cardiac phenotypes. A non-invasive method of recording electrocardiograms (ECGs) was used to a study mdx mice (n=15) and control mice (n=15). The mdx mice had significant tachycardia, consistent with observations in patients with muscular dystrophy. Heart-rate was nearly 15% faster in mdx mice than control mice (P<0.01). ECGs revealed significant shortening of the rate-corrected QT interval duration (QTc) in mdx mice compared to control mice (P<0.05). PR interval duration were shorter at baseline in mdx compared to control mice (P<0.05). The muscarinic antagonist atropine significantly increased heart-rate and decreased PR interval duration in C57 mice. Paradoxically, atropine significantly decreased heart-rate and increased PR interval duration in all mdx mice.

Abstract: A method and apparatus for recording and analyzing the gait of an animal is provided. The apparatus can take the form of a gait imaging system. The system includes a movable belt track upon which a subject can ambulate. An imaging device is disposed below the belt track to record contact between at least one limb of the subject and the belt track. The subject can ambulate along the belt track in a substantially stationary location above the imaging device as the belt track moves, and the imaging device can record the contact by the subject. A method of recording a gait of an ambulating subject is also provided. The method includes locating the subject on a movable belt track. The subject is motivated to ambulate along the movable belt track at about the same rate as the movable belt track, while the belt track is moving, such that the location of the subject does not substantially change.

Abstract: A method and apparatus for enabling the non-invasive acquisition of physiological parameters of a mammal, while allowing the mammal to move around a predetermined area is provided. In accordance with one example embodiment, a monitoring device for non-invasively acquiring physiological measurements of a mammal is provided. The device includes a first electrode configured to attach to an ear of the mammal in a manner suitable for obtaining a first electrical signal. A second electrode is configured to attach to a first alternate location of the mammal in a manner suitable for obtaining a second electrical signal. A third electrode is configured to attach to a second alternate location of the mammal in a manner suitable for obtaining a third electrical signal. The first electrode, second electrode, and third electrode are in communication with a signal receiver. Physiological parameters, such as those associated with electrocardiograms, can be obtained using the monitoring device.

Abstract: The mdx mouse is a model of Duchenne muscular dystrophy. The present invention describes that mdx mice exhibited clinically relevant cardiac phenotypes. A non-invasive method of recording electrocardiograms (ECGs) was used to a study mdx mice (n=15) and control mice (n=15). The mdx mice had significant tachycardia, consistent with observations in patients with muscular dystrophy. Heart-rate was nearly 15% faster in mdx mice than control mice (P<0.01). ECGs revealed significant shortening of the rate-corrected QT interval duration (QTc) in mdx mice compared to control mice (P<0.05). PR interval duration were shorter at baseline in mdx compared to control mice (P<0.05). The muscarinic antagonist atropine significantly increased heart-rate and decreased PR interval duration in C57 mice. Paradoxically, atropine significantly decreased heart-rate and increased PR interval duration in all mdx mice.

Abstract: A novel method and apparatus for obtaining the electrocardiogram (ECG) in small conscious animals, such as mice, without the need to anesthetize or instrument the animal, are described. The apparatus includes an array of conductive pads, embedded in a platform, the pads sized and spaced to advance contact between an animal's paws and the pads as the animal freely moves upon the platform. Electrical circuitry to the pads is configured to sense the parings of pads and paws that render an interpretable ECG signal and to activate or deactivate recording of the signals. The apparatus is suspended above a surface to minimize the range of motion of the animal without physical restraint.

Abstract: Methods and systems for remotely analyzing signals through a communications network. In one embodiment, the methods and systems may be adapted to a subscriber medical research facility wherein data is collected from samples for further analysis. The methods and systems provide a graphical user interface to allow the subscriber to collect data through a data acquisition system, classify the waveforms, select appropriate analysis algorithms and results, and further choose algorithm parameters. The data and all subscriber entered options may be transmitted through a communications system to a remote analysis engine that may be coupled to a database. The remote analysis engine may analyze the data in accordance with the analysis options. In some embodiments, the analysis results may be obtained or further incorporated into the database. The analysis results may also be transmitted through the communications network, to the subscriber for further review and editing by the subscriber.

Abstract: A magnet piece and armature are arranged around a circuit breaker load strap having a bimetal strip attached thereto. The magnet piece is formed in a U-shaped configuration and is attached to the load strap. A corresponding U-shaped armature is pivotally mounted to the magnet piece in a partially overlapping relation. The U-shape armature presents a larger magnet pole surface to the magnet piece for enhanced magnetic interaction.

Abstract: A selectable rating plug allows a standard molded case circuit breaker design to be used over a wide range of ampere ratings. The rating plug is used to control the thermal load on the thermally responsive trip element within the breaker. Movement of the thermally responsive element articulates the breaker trip mechanism in response to predetermined overload conditions to interrupt circuit current.