Abstract: A hand tool for use in providing protective manual assistance in opening frangible hermetically sealed ampuls having an elongated main body portion and an integral axially projecting removable end merging with the body portion through a peripherally constricted and relatively weakened neck designed to fracture and separate the removable end from the body portion in response to a bending stress manually applied to the removable end portion. The hand tool comprises an essentially rigid one-piece construction which may be manually gripped within one hand of the user and which is designed to accommodate its reuse with widely varying ampul sizes. The hand tool features a pair of elongate protective finger grips arranged in side-by-side interspaced relationship at one end and integrally merging together at an opposite longitudinal end to define a generally U-shaped central recess within which to position the removable end of a sealed ampul.